Volume 18, Issue 2 (Summer 2021)
Sci J Iran Blood Transfus Organ 2021, 18(2): 142-147 |
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Safavi M, Safaei A, Fathpour G. A Case Report of Acute T Cell Lymphoblastic Leukemia with Complex Chromosomal Abnormalities in a Child with Ataxia Telangiectasia. Sci J Iran Blood Transfus Organ 2021; 18 (2) :142-147
URL: http://bloodjournal.ir/article-1-1395-en.html
URL: http://bloodjournal.ir/article-1-1395-en.html
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| Abstract (HTML) (1692 Views)
A Case Report of Acute T Cell Lymphoblastic Leukemia
with Complex Chromosomal Abnormalities in a Child
with Ataxia Telangiectasia
Safavi M.1, Safaei A.2, Fathpour Gh.R.3
1Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Pathology Department, Medical Faculty, Shiraz University of Medical Sciences, Shiraz, Iran
3Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background and Objectives
Ataxia telangiectasia is a disease with chromosomal instability that causes susceptibility to malignancy.
Case
The patient was a 7-year-old boy living in Shiraz who had ataxia telangiectasia and was hospitalized due to fever and lymphadenopathy. Bone marrow aspiration showed a 60% blast population that was consistent with acute T cell lymphoblastic leukemia, immunophenotypically. In cytogenetic examination of bone marrow aspiration, complex chromosomal abnormalities as 42,XY,-5,del(6)(q22),der(8)t(8;17)(q24;q12~q22),t(9;16) (q12;q24),dic(12;14)(p11;q24),+13,-14,-22 were observed. Despite chemotherapy, the patient expired after two relapses of leukemia.
Conclusions
T cell acute lymphoblastic leukemia due to ataxia telangiectasia can be associated with complex karyotype abnormalities leading to leukemia relapse and adverse prognosis.
Key words: Ataxia Telangiectasia, Cytogenetic Aberrations, Leukemia
Received: 13 Feb 2021
Accepted: 1 May 2021
Correspondence: Safavi M., MD, Pathlogist and Fellow of Molecular Pathology and Cytogenetics. Assistant Professor of Pathology Department, Children's Medical Center, Tehran University of Medical Sciences.
Postal code: 1419733151, Tehran, Iran. Tel: (+9821) 61472404; Fax: (+9821) 66948780
E-mail: moein.safavi@gmail.com
Full-Text: (1263 Views)
References:
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- Janic D, Dokmanovic L, Jovanovic N, Lazic J. T-cell acute lymphoblastic leukemia in a child with ataxia-telangiectasia: case report. J Pediatr Hematol Oncol 2007; 29(10): 713-5.
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Sci J Iran Blood Transfus Organ 2021; 18 (2): 142-147 |
|
Case report
|
A Case Report of Acute T Cell Lymphoblastic Leukemia
with Complex Chromosomal Abnormalities in a Child
with Ataxia Telangiectasia
Safavi M.1, Safaei A.2, Fathpour Gh.R.3
1Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Pathology Department, Medical Faculty, Shiraz University of Medical Sciences, Shiraz, Iran
3Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background and Objectives
Ataxia telangiectasia is a disease with chromosomal instability that causes susceptibility to malignancy.
Case
The patient was a 7-year-old boy living in Shiraz who had ataxia telangiectasia and was hospitalized due to fever and lymphadenopathy. Bone marrow aspiration showed a 60% blast population that was consistent with acute T cell lymphoblastic leukemia, immunophenotypically. In cytogenetic examination of bone marrow aspiration, complex chromosomal abnormalities as 42,XY,-5,del(6)(q22),der(8)t(8;17)(q24;q12~q22),t(9;16) (q12;q24),dic(12;14)(p11;q24),+13,-14,-22 were observed. Despite chemotherapy, the patient expired after two relapses of leukemia.
Conclusions
T cell acute lymphoblastic leukemia due to ataxia telangiectasia can be associated with complex karyotype abnormalities leading to leukemia relapse and adverse prognosis.
Key words: Ataxia Telangiectasia, Cytogenetic Aberrations, Leukemia
Received: 13 Feb 2021
Accepted: 1 May 2021
Correspondence: Safavi M., MD, Pathlogist and Fellow of Molecular Pathology and Cytogenetics. Assistant Professor of Pathology Department, Children's Medical Center, Tehran University of Medical Sciences.
Postal code: 1419733151, Tehran, Iran. Tel: (+9821) 61472404; Fax: (+9821) 66948780
E-mail: moein.safavi@gmail.com
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