Volume 18, Issue 2 (Summer 2021)
Sci J Iran Blood Transfus Organ 2021, 18(2): 142-147 |
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Safavi M, Safaei A, Fathpour G. A Case Report of Acute T Cell Lymphoblastic Leukemia with Complex Chromosomal Abnormalities in a Child with Ataxia Telangiectasia. Sci J Iran Blood Transfus Organ 2021; 18 (2) :142-147
URL: http://bloodjournal.ir/article-1-1395-en.html
URL: http://bloodjournal.ir/article-1-1395-en.html
Abstract: (1630 Views)
Abstract
Background and Objectives
Ataxia telangiectasia is a disease with chromosomal instability that causes susceptibility to malignancy.
Case
The patient was a 7-year-old boy living in Shiraz who had ataxia telangiectasia and was hospitalized due to fever and lymphadenopathy. Bone marrow aspiration showed a 60% blast population that was consistent with acute T cell lymphoblastic leukemia, immunophenotypically. In cytogenetic examination of bone marrow aspiration, complex chromosomal abnormalities as 42,XY,-5,del(6)(q22),der(8)t(8;17)(q24;q12~q22),t(9;16) (q12;q24),dic(12;14)(p11;q24),+13,-14,-22 were observed. Despite chemotherapy, the patient expired after two relapses of leukemia.
Conclusions
T cell acute lymphoblastic leukemia due to ataxia telangiectasia can be associated with complex karyotype abnormalities leading to leukemia relapse and adverse prognosis.
Background and Objectives
Ataxia telangiectasia is a disease with chromosomal instability that causes susceptibility to malignancy.
Case
The patient was a 7-year-old boy living in Shiraz who had ataxia telangiectasia and was hospitalized due to fever and lymphadenopathy. Bone marrow aspiration showed a 60% blast population that was consistent with acute T cell lymphoblastic leukemia, immunophenotypically. In cytogenetic examination of bone marrow aspiration, complex chromosomal abnormalities as 42,XY,-5,del(6)(q22),der(8)t(8;17)(q24;q12~q22),t(9;16) (q12;q24),dic(12;14)(p11;q24),+13,-14,-22 were observed. Despite chemotherapy, the patient expired after two relapses of leukemia.
Conclusions
T cell acute lymphoblastic leukemia due to ataxia telangiectasia can be associated with complex karyotype abnormalities leading to leukemia relapse and adverse prognosis.
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