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:: Volume 17, Issue 2 (Summer 2020) ::
Sci J Iran Blood Transfus Organ 2020, 17(2): 147-169 Back to browse issues page
Mesenchymal Stem Cells: Interactions with Immune Cells and Immunosuppressive-Immunomodulatory Properties
S.M. Hoseini , ّF. Kalantar , S.M. Kalantar , A.R. Bahrami , F. Zareien , M. Moghadam matin
Keywords: Mesenchymal Stem Cells, Immunomodulation, Immunosuppression, Regenerative Medicine, Cell Therapy
Full-Text [PDF 855 kb]   (1393 Downloads)     |   Abstract (HTML)  (3255 Views)
Type of Study: Review Article | Subject: Stem cells
Published: 2020/06/30
Full-Text:   (5583 Views)
    References:
 
 
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Sci J Iran Blood Transfus Organ 2020;17(2); 147-169
Review  Article
 

 
 

 
Mesenchymal Stem Cells: Interactions with Immune
Cells and Immunosuppressive-Immunomodulatory
Properties
 
Hoseini S.M.1,2, Montazeri F.3, Kalantar S.M.2, Bahrami A.R.1, Zareien F.3, Matin M.M.1
 
1Department of Biology and Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
2Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
 
Abstract
Background and Objectives
Recently, mesenchymal stem cells have attracted much attention in regenerative medicine and cell-based therapies. Mesenchymal stem cells are used in regenerative medicine mainly based on their capacity to differentiate into several cell lineages, low immunogenicity, and in particular their anti-inflammatory and immunosuppressive-immunomodulatory properties.
 
Materials and Methods
The present manuscript, by reviewing more than 150 recent published articles, introduces the latest information regarding the anti-inflammatory and immunosuppressive-immunomodulatory properties of the mesenchymal stem cells.
 
Results
The fibroblast-like mesenchymal stem cells can be isolated from various sources such as bone marrow, adipose tissue, skeletal muscle, Wharton jelly, umbilical cord, placenta, and amniotic fluid. The immunomodulatory properties of mesenchymal stem cells result from their interactions with innate and adaptive immune systems to inhibit immune cells. Such an inhibitory function is due to the interaction of these cells with immune cells through direct cell-cell contact or via paracrine secretory factors. The composition of these secretions or secretom of these cells includes various components such as growth factors, cytokines, chemokines, anti-inflammatory mediators and exosomes. Many in vivo studies in animal models have demonstrated that the ability of mesenchymal stem cells to regenerate and repair tissues is more attributed to their immunosuppressive-immunomodulatory function rather than their proliferative properties.
 
Conclusions 
Therefore, understanding the mechanisms establishing the interactions of these cells with immune system would be important for their use as a promising therapeutic approach in the future for treatment of immunological diseases as well as in the field of regenerative medicine.
 
Key words: Mesenchymal Stem Cells, Immunomodulation, Immunosuppression, Regenerative Medicine, Cell Therapy
 
Received:  13 Oct 2019
Accepted: 11 Jan 2020
 
 

Correspondence: Matin MM., PhD of Molecular Biology. Professor, Faculty of Science, Ferdowsi University of Mashhad.
Postal Code: 9177948974, Mashhad, Iran. Tel: (+9851) 38805514;  Fax: (+9851) 38796416
E-mail: matin@um.ac.ir
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Hoseini S, Kalantar ّ, Kalantar S, Bahrami A, Zareien F, Moghadam matin M. Mesenchymal Stem Cells: Interactions with Immune Cells and Immunosuppressive-Immunomodulatory Properties. Sci J Iran Blood Transfus Organ 2020; 17 (2) :147-169
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