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:: Volume 17, Issue 2 (Summer 2020) ::
Sci J Iran Blood Transfus Organ 2020, 17(2): 147-169 Back to browse issues page
Mesenchymal Stem Cells: Interactions with Immune Cells and Immunosuppressive-Immunomodulatory Properties
Seyed Mehdi Hoseini, ّF. Kalantar Dr., S.M. Kalantar Dr., A.R. Bahrami Dr., F. Zareien, M. Moghadam matin Dr.
Abstract:   (654 Views)
Abstract
Background and Objectives
Recently, mesenchymal stem cells have attracted much attention in regenerative medicine and cell-based therapies. Mesenchymal stem cells are used in regenerative medicine mainly based on their capacity to differentiate into several cell lineages, low immunogenicity, and in particular their anti-inflammatory and immunosuppressive-immunomodulatory properties.
 
Materials and Methods
The present manuscript, by reviewing more than 150 recent published articles, introduces the latest information regarding the anti-inflammatory and immunosuppressive-immunomodulatory properties of the mesenchymal stem cells.
 
Results
The fibroblast-like mesenchymal stem cells can be isolated from various sources such as bone marrow, adipose tissue, skeletal muscle, Wharton jelly, umbilical cord, placenta, and amniotic fluid. The immunomodulatory properties of mesenchymal stem cells result from their interactions with innate and adaptive immune systems to inhibit immune cells. Such an inhibitory function is due to the interaction of these cells with immune cells through direct cell-cell contact or via paracrine secretory factors. The composition of these secretions or secretom of these cells includes various components such as growth factors, cytokines, chemokines, anti-inflammatory mediators and exosomes. Many in vivo studies in animal models have demonstrated that the ability of mesenchymal stem cells to regenerate and repair tissues is more attributed to their immunosuppressive-immunomodulatory function rather than their proliferative properties.
 
Conclusions 
Therefore, understanding the mechanisms establishing the interactions of these cells with immune system would be important for their use as a promising therapeutic approach in the future for treatment of immunological diseases as well as in the field of regenerative medicine.
 
Keywords: Mesenchymal Stem Cells, Immunomodulation, Immunosuppression, Regenerative Medicine, Cell Therapy
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Type of Study: Review Article | Subject: Stem cells
Published: 2020/06/30
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Hoseini S M, Kalantar ّ, Kalantar S, Bahrami A, Zareien F, Moghadam matin M. Mesenchymal Stem Cells: Interactions with Immune Cells and Immunosuppressive-Immunomodulatory Properties. Sci J Iran Blood Transfus Organ. 2020; 17 (2) :147-169
URL: http://bloodjournal.ir/article-1-1313-en.html


Volume 17, Issue 2 (Summer 2020) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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