Abstract

 Background and Objectives

  β -thalassemia is the most common monogenic autosomal recessive all over the world. Therefore, identifying carriers and performing prenatal testing can prevent the birth of a new patient.

 Case

 The young couple resident in Bandar Abbas with their son were referred to the Genetic Laboratory with hematological parameters that indicated minor thalassemia and implicated a symptom of an unknown hemoglobin in the father. Based on the genetic study, the father carried a rare mutation in CD56 (GGC > CGC) leading to Hb-Hamadan.

 Conclusions

 In this study seems that Hb-Hamdan has no pathological effect and . This point is very important particularly in prenatal diagnosis (PND).