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URL: http://bloodjournal.ir/article-1-41-en.html
Abstract
Background and Objectives
Conditions for preparation and storage of platelets for transfusion purposes may lead to platelet activation which in turn contributes to decreased ability of stored platelets to function and to survive in vivo after transfusion as compared with freshly prepared platelets. We investigated platelet membrane expression of CD62P, CD63 in platelet stored for up to 3 days under standard blood banking conditions.
Materials and Methods
Twenty-four platelet units prepared by platelet-rich-plasma and platelet concentrates were evaluated during storage for markers CD62P, CD63 and pH.
Results
During storage for up to 3 days platelet units displayed no significant pH (p>0.05). During storage for up to 3 days (days 1 and 3) platelet units were significant in the CD62P and CD63 expressions as compared with day 0 (p<0.05).
Conclusions
Storage of platelet concentrates causes activated platelets. Moreover, these markers (CD62P and CD63) can act as useful in vitro means in the quality control of platelet components.
Key words: Platelet-rich-plasma, CD62P, CD63
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