Volume 21, Issue 4 (Winter 2024)
Sci J Iran Blood Transfus Organ 2024, 21(4): 269-273 |
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Yazdandoust E, Maghsudlu M. The Critical Significance of Vigilance and Recruitment of Hematopoietic Stem Cell Donors. Sci J Iran Blood Transfus Organ 2024; 21 (4) :269-273
URL: http://bloodjournal.ir/article-1-1568-en.html
URL: http://bloodjournal.ir/article-1-1568-en.html
Abstract: (463 Views)
A B S T R A C T
Background and Objectives
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) stands as a cornerstone treatment for hematologic malignancies and various blood disorders. As its utilization continues to grows, ensuring donor awareness and effective recruitment strategies have become increasingly crucial. This study aims to examine key aspects of donor care and propose measures to improve donor engagement.
Materials and Methods
This letter to the editor highlights evidence from international scientific literature and experiential data to explore critical aspects of donor assessment, screening, follow-up, and care. Additionally, it outlines practical recommendations aimed at strengthening donor recruitment and vigilance systems ensuring a more effective approach to stem cell donation.
Results
Comprehensive donor vigilance system involves rigorous screening, monitoring of donation procedures, systematic adverse event reporting, and long-term follow-up. Enhancing appropriate infrastructure, raising public awareness, leveraging the existing blood donor base, and developing a well-organized donor registries significantly improve the effectiveness of stem cell donor banks. Furthermore, addressing ethical considerations and offering psychological and social support play a vital role in fostering donor trust and encouraging active participation.
Conclusions
Strengthening vigilance systems and raising public awareness regarding stem cell donation contribute not only for donor health and safety but also for optimizing transplant success and expanding patient access to life-saving therapies. Strategic policy development and supportive frameworks are essential to advancing donor registries and promoting public health in this critical area.
Background and Objectives
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) stands as a cornerstone treatment for hematologic malignancies and various blood disorders. As its utilization continues to grows, ensuring donor awareness and effective recruitment strategies have become increasingly crucial. This study aims to examine key aspects of donor care and propose measures to improve donor engagement.
Materials and Methods
This letter to the editor highlights evidence from international scientific literature and experiential data to explore critical aspects of donor assessment, screening, follow-up, and care. Additionally, it outlines practical recommendations aimed at strengthening donor recruitment and vigilance systems ensuring a more effective approach to stem cell donation.
Results
Comprehensive donor vigilance system involves rigorous screening, monitoring of donation procedures, systematic adverse event reporting, and long-term follow-up. Enhancing appropriate infrastructure, raising public awareness, leveraging the existing blood donor base, and developing a well-organized donor registries significantly improve the effectiveness of stem cell donor banks. Furthermore, addressing ethical considerations and offering psychological and social support play a vital role in fostering donor trust and encouraging active participation.
Conclusions
Strengthening vigilance systems and raising public awareness regarding stem cell donation contribute not only for donor health and safety but also for optimizing transplant success and expanding patient access to life-saving therapies. Strategic policy development and supportive frameworks are essential to advancing donor registries and promoting public health in this critical area.
References
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2. Shaw BE, Ball L, Beksac M, Bengtsson M, Confer D, Diler S, et al. Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated donors: clinical and ethical considerations. Bone Marrow Transplant 2010; 45(5): 832-8. [DOI:10.1038/bmt.2010.2] [PMID]
3. Switzer GE, Dew MA, Stukas AA, Goycoolea JM, Hegland J, Simmons RG. Factors associated with attrition from a national bone marrow registry. Bone Marrow Transplant 1999; 24(3): 313-9. [DOI:10.1038/sj.bmt.1701884] [PMID]
4. Lown RN, Philippe J, Navarro W, van Walraven SM, Philips-Johnson L, Fechter M, et al. Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group Committee. Bone Marrow Transplant 2014; 49(7): 880-6. [DOI:10.1038/bmt.2014.67] [PMID]
5. World Marrow Donor Association (WMDA). Recommendations for Enhancing the Global Regulatory Oversight of the Selection of Hematopoietic Progenitor Cells Donors. 2020. Available from: https://wmda.info/
6. Worel N, Aljurf M, Anthias C, Buser AS, Cody M, Fechter M, et al. Suitability of haematopoietic cell donors: updated consensus recommendations from the WBMT standing committee on donor issues. Lancet Haematol 2022; 9(8): e605-e14. [DOI:10.1016/S2352-3026(22)00184-3] [PMID]
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