Volume 21, Issue 4 (Winter 2024)
Sci J Iran Blood Transfus Organ 2024, 21(4): 269-272 |
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Yazdandoust E, Maghsudlu M. The critical significance of hematopoietic stem cell donor vigilance and recruitment. Sci J Iran Blood Transfus Organ 2024; 21 (4) :269-272
URL: http://bloodjournal.ir/article-1-1568-en.html
URL: http://bloodjournal.ir/article-1-1568-en.html
Abstract: (293 Views)
A B S T R A C T
Background and Objectives
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most effective therapeutic approaches for hematologic malignancies and various blood disorders. Given the increasing reliance on this treatment modality, there is a pressing need to enhance awareness about donor vigilance and implement strategies to effectively recruit stem cell donors. This study aims to examine key aspects of donor care and propose measures to improve donor engagement.
Materials and Methods
This letter to the editor reviews evidence from international scientific literature and experiential data to explore processes related to donor assessment, screening, follow-up, and support. It also outlines practical recommendations for strengthening donor recruitment and vigilance systems.
Results
Comprehensive donor care encompasses rigorous screening, careful monitoring of donation procedures, adverse event reporting, and long-term follow-up. Establishing appropriate infrastructure, raising public awareness, leveraging the existing blood donor base, and developing structured donor registries significantly enhance the effectiveness of stem cell donor banks. Furthermore, addressing ethical considerations and providing psychological and social support fosters donor trust and participation.
Conclusions
Strengthening vigilance systems and raising public awareness regarding stem cell donation contribute not only to donor health and safety but also improve transplant outcomes and patient access to life-saving therapies. Coordinated policy development and supportive frameworks are essential to advancing donor registries and promoting public health in this critical area.
Background and Objectives
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most effective therapeutic approaches for hematologic malignancies and various blood disorders. Given the increasing reliance on this treatment modality, there is a pressing need to enhance awareness about donor vigilance and implement strategies to effectively recruit stem cell donors. This study aims to examine key aspects of donor care and propose measures to improve donor engagement.
Materials and Methods
This letter to the editor reviews evidence from international scientific literature and experiential data to explore processes related to donor assessment, screening, follow-up, and support. It also outlines practical recommendations for strengthening donor recruitment and vigilance systems.
Results
Comprehensive donor care encompasses rigorous screening, careful monitoring of donation procedures, adverse event reporting, and long-term follow-up. Establishing appropriate infrastructure, raising public awareness, leveraging the existing blood donor base, and developing structured donor registries significantly enhance the effectiveness of stem cell donor banks. Furthermore, addressing ethical considerations and providing psychological and social support fosters donor trust and participation.
Conclusions
Strengthening vigilance systems and raising public awareness regarding stem cell donation contribute not only to donor health and safety but also improve transplant outcomes and patient access to life-saving therapies. Coordinated policy development and supportive frameworks are essential to advancing donor registries and promoting public health in this critical area.
References
1. Halter J, Kodera Y, Ispizua AU, Greinix HT, Schmitz N, Favre G, et al. Severe events in donors after allogeneic hematopoietic stem cell donation. Haematologica 2009; 94(1): 94-101. [DOI:10.3324/haematol.13668] [PMID] []
2. Shaw BE, Ball L, Beksac M, Bengtsson M, Confer D, Diler S, et al. Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated donors: clinical and ethical considerations. Bone Marrow Transplant 2010; 45(5): 832-8. [DOI:10.1038/bmt.2010.2] [PMID]
3. Switzer GE, Dew MA, Stukas AA, Goycoolea JM, Hegland J, Simmons RG. Factors associated with attrition from a national bone marrow registry. Bone Marrow Transplant 1999; 24(3): 313-9. [DOI:10.1038/sj.bmt.1701884] [PMID]
4. Lown RN, Philippe J, Navarro W, van Walraven SM, Philips-Johnson L, Fechter M, et al. Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group Committee. Bone Marrow Transplant 2014; 49(7): 880-6. [DOI:10.1038/bmt.2014.67] [PMID]
5. World Marrow Donor Association (WMDA). Recommendations for Enhancing the Global Regulatory Oversight of the Selection of Hematopoietic Progenitor Cells Donors. 2020. Available from: https://wmda.info/
6. Worel N, Aljurf M, Anthias C, Buser AS, Cody M, Fechter M, et al. Suitability of haematopoietic cell donors: updated consensus recommendations from the WBMT standing committee on donor issues. Lancet Haematol 2022; 9(8): e605-e14. [DOI:10.1016/S2352-3026(22)00184-3] [PMID]
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