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Reviewing the effect of exercise on hematopoietic stem cell mobilization
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S. Hedayati   , A.R. Rahimi , F. Aghaei , M. Mohsenzadeh |
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Abstract: (506 Views) |
Abstract
Background and Objectives
Hematopoietic stem cell transplantation (HSCT) is a promising treatment for the hematological disease. Although bone marrow is the major source of hematopoietic stem cells (HSCs), there is a small compartment of these cells in peripheral blood. Mobilization is the process of HSCs release into the peripheral blood, induced by several physiological and pharmaceutical factors. Granulocytecolony-stimulating factor (G-CSF) is the main exogenous drug for mobilization induction. The exercise is a non-invasive approach for mobilization stimulation.
Materials and Methods
In this review, we searched the keywords of hematopoietic stem cell transplantation, mobilization, and exercise in reliable databases, including Google Scholar, PubMed, Scopus, and Elsevier. We selected the most relevant ones among potential candidates. Among the 98 selected articles, 63 articles met the necessary criteria and were evaluated.
Results
Exercise is safe and feasible in patients undergoing HSCT and can induce a 2-4 fold increase in peripheral blood HSC quantity. However, the influence is transient and drops back to baseline shortly after the exercise. Studies suggested that exercise-induced mobilization is intensity-dependent, and higher-intensity exercise induces mobilization more effectively than lower intensity.
Conclusions
As the exercise’s effect is transient and insufficient compared to G-CSF, it cannot fully replace the exogenous G-CSF therapy in the clinic. However, it can be applied along with G-CSF as an adjuvant therapy to help with reducing apheresis time and duration, decreasing G-CSF dose and its related side effects, and preventing extra pharmaceutical interventions.
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| Keywords: Key words: Hematopoietic Stem Cell Transplantation, Exercise, G-CSF |
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Full-Text [PDF 549 kb]
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Type of Study: Review Article |
Subject:
Hematology
Published: 2023/07/1
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