Volume 12, Issue 3 (Autumn 2015)                   Sci J Iran Blood Transfus Organ 2015, 12(3): 292-302 | Back to browse issues page

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Saleh M, Shams Asanjan K, Movassaghpour Akbari A, Akbarzadeh P, Molaeipour Z. The Effect of Mesenchymal Stem Cells on Hematopoetic Stem Cells Differentiation. Sci J Iran Blood Transfus Organ 2015; 12 (3) :292-302
URL: http://bloodjournal.ir/article-1-894-en.html
The Effect of Mesenchymal Stem Cells on Hematopoetic Stem Cells Differentiation
M. Saleh , K. Shams Asanjan * , A.A. Movassaghpour Akbari , P. Akbarzadeh , Z. Molaeipour
Keywords: Key words : Mesenchymal Stem Cells, Hematopoietic Stem Cells, Cell Differentiation
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Sci J Iran Blood Transfus Organ 2015; 12(3): 292-302
 
Review Article
 
 

The Effect of Mesenchymal Stem Cells on Hematopoetic
Stem Cells Differentiation
 
Saleh M.1, Shams Asanjan K.1,2,3, Movassaghpour Akbari A.A.1, Akbarzadeh P.4,
Molaeipour Z.1
 
1Hematology Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3Tabriz Educational Regional Blood Transfusion Center, Tabriz, Iran
4Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
 
Abstract
Background and Objectives
Bone marrow microenviroment contains cellular and acellular compartments. Cellular compartment contains hematopoetic stem cells, mesenchymal stem cells and some other kinds of stromal cells while acellular compartment includes scaffold proteins known as an extra cellular matrix. Hematopoietic stem cells resided in the bone marrow interact with a bone marrow microenvironment called the stem cell niche. Hematopoietic stem cells (HSCs) are able to produce the variety of blood cells and bone marrow microenvironment plays a supportive role for the cells in this process. Recent studies over in-vitro models demonstrating the essential role of stromal cells in hematopoiesis reflected the view that cell-cell contact in the marrow microenvironment is critical for hematopoietic stem cells normal function and differentiation. Direct cell-cell contacts and cytokines secreted by mesenchymal stem cells  play a critical role in the coculture of hematopoetic stem cells and mesenchymal stem cells and the determination of the fate of hematopoetic stem cells. Several studies demonstrate the effect of mesenchymal stem cells on self renewal, expansion, proliferation and differentiation of hematopoetic stem cells in vitro that lead to different and contradictory results. In this paper, we will investigate the effect of  mesenchymal stem cells on differentiation of hematopoietic stem cells in vitro.
 
Materials and Methods
The data of the present article were obtained through the review of many papers published on the effect of stem cells.
 
Results
The review of different studies has shown the necessity to survey the effect of mesenchymal stem cells on differentiation of different cell lines as a laboratory model.
 
Conclusions
Direct cell-cell contact between mesenchymal stem cells and hematopoietic stem cells and the signaling pathways activated by this interaction enable proliferation and expansion of HSCs in the undifferentiated state.
 
Key words: Mesenchymal Stem Cells, Hematopoietic Stem Cells, Cell Differentiation
 
Received: 23 Aug 2014
Accepted:17 Jan  2015
 
 
 
 

Correspondence: Shams Asanjan K., PhD of Hematology and Blood Banking. Assistant Professor of Hematology Oncology Research Center, Tabriz University of Medical Sciences and Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Tabriz Educational Regional Blood Transfusion Center.
P.O.Box: 51335, Tabriz , Iran. Tel: (+98411) 2871515; Fax: (+98411) 2871515
                E-mail: k.shams@ibto.ir
Type of Study: Review Article | Subject: Hematology
Published: 2015/09/2
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