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Naghavian R, Honardoost M, Hosseini A, Ghaedi K, Etemadifar M, Nasr Esfahani M et al . The possibility of miR-20a/b & miR-93 role in differentiation of naïve CD4+ to Th17 cells in multiple sclerosis. bloodj 2015; 12 (1) :39-45
URL: http://bloodjournal.ir/article-1-845-en.html
The possibility of miR-20a/b & miR-93 role in differentiation of naïve CD4+ to Th17 cells in multiple sclerosis
R. Naghavian , M.A. Honardoost , A. Hosseini , K. Ghaedi * , M. Etemadifar , M. Nasr Esfahani , M. Ganjalikhani Hakemi
Keywords: Key words : Multiple Sclerosis, MicroRNAs, Th17 Cells, Autoimmune Diseases
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Sci J Iran Blood Transfus Organ 2015; 12(1): 39-45
 
Original  Article
 
 

The possibility of miR-20a/b & miR-93 role in
differentiation of naïve CD4+ to Th17 cells
in multiple sclerosis
 
Naghavian R.1, Honardoost M.A.1, Hosseini A.1, Ghaedi K.2,3, Etemadifar M.4,
Nasr Esfahani M.H.3, Ganjalikhani Hakemi M.5,6
 
 
1University of Isfahan, Isfahan, Iran
2School of Science, University of Isfahan, Isfahan, Iran
3Department of Cellular Biotechnology at Cell Science Research Center, ACECR, Royan Institute for Biotechnology, Isfahan, Iran
4Isfahan University of Medical Sciences, Isfahan, Iran
5Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
6Cellular & Molecular Immunology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
 
Abstract
Background and Objectives
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease in which the body’s natural defense system attacks myelin on neuronal cells. One of the most important immune system cells involved in MS is Th17 which is one of the main cells involved in most of autoimmune diseases. Recently, microRNAs (miRNAs) have been remarkably used in treating many kinds of diseases. MicroRNAs are endogenous 22-25 nt RNAs playing an important regulatory roles in cellular and developmental processes.
 
Materials and Methods
The goal of this article is to determine miRNAs which possibly have the most effect in the pathway of differentiation to Th17 cells by using miRWalk database and candidate microRNAs that can suppress this pathway and limit the disease’s symptoms. Our in-silico studies identified the possible role of several miRNAs in differentiation of naïve CD4+ cells to Th17 cells.
 
Results
miR-93,miR-20a/b are probably applicable to inhibit the differentiation of naïve T cells into Th17 cells to reduce the progress of MS and also to be used as markers of diagnosis of MS in early stages.
 
Conclusions
According to our results miR-20a/b&miR-93 can possibly be the key miRNAs, inhibiting the progression of MS by preventing the differentiation to Th17 cells.
 
Key words: Multiple Sclerosis, MicroRNAs, Th17 Cells, Autoimmune Diseases
 
 
Received: 11 Mar 2014
Accepted: 24 Sep 2014
 

 

Correspondence: Ghaedi K, PhD of Molecular Biology. Associate Professor of School of Science , Isfahan University of Medical Sciences & Department of Cellular Biotechnology at Cell Science Research Center, ACECR, Royan Institute for Biotechnology.
Postal code: 81746-73441, Isfahan, Iran. Tel: (+98311) 7932479 ; Fax: (+98311) 7932456
E-mail: kamranghaedi@yahoo.com
Type of Study: Research | Subject: Imunology
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