Volume 12, Issue 1 (Spring 2015)                   Sci J Iran Blood Transfus Organ 2015, 12(1): 39-45 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Naghavian R, Honardoost M, Hosseini A, Ghaedi K, Etemadifar M, Nasr Esfahani M et al . The possibility of miR-20a/b & miR-93 role in differentiation of naïve CD4+ to Th17 cells in multiple sclerosis. Sci J Iran Blood Transfus Organ 2015; 12 (1) :39-45
URL: http://bloodjournal.ir/article-1-845-en.html
Abstract:   (7862 Views)

  Abstract

 Background and Objectives

 Multiple sclerosis (MS) is an autoimmune neurodegenerative disease in which the body’s natural defense system attacks myelin on neuronal cells. One of the most important immune system cells involved in MS is Th17 which is one of the main cells involved in most of autoimmune diseases. Recently, microRNAs (miRNAs) have been remarkably used in treating many kinds of diseases. MicroRNAs are endogenous 22-25 nt RNAs playing an important regulatory roles in cellular and developmental processes.

 

 Materials and Methods

 The goal of this article is to determine miRNAs which possibly have the most effect in the pathway of differentiation to Th17 cells by using miRWalk database and candidate microRNAs that can suppress this pathway and limit the disease’s symptoms. Our in-silico studies identified the possible role of several miRNAs in differentiation of naïve CD4+ cells to Th17 cells. 

  

 Results

 miR-93,miR-20a/b are probably applicable to inhibit the differentiation of naïve T cells into Th17 cells to reduce the progress of MS and also to be used as markers of diagnosis of MS in early stages. 

 

 Conclusions

 According to our results miR-20a/b&miR-93 can possibly be the key miRNAs, inhibiting the progression of MS by preventing the differentiation to Th17 cells.

 

 

 

Full-Text [PDF 315 kb]   (2099 Downloads) |   |   Full-Text (HTML)  (1694 Views)  
Type of Study: Research | Subject: Imunology
Published: 2015/04/7

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Scientific Journal of Iran Blood Transfus Organ

Designed & Developed by : Yektaweb