Volume 11, Issue 3 (Autumn 2014)
Sci J Iran Blood Transfus Organ 2014, 11(3): 252-256 |
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Soleimani H, Malekzadeh K, Shekari M, Paran F, Bazmjou M, Namjou E et al . A case report of Hemoglobin Hamadan in Hormozgan province. Sci J Iran Blood Transfus Organ 2014; 11 (3) :252-256
URL: http://bloodjournal.ir/article-1-816-en.html
URL: http://bloodjournal.ir/article-1-816-en.html
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| Abstract (HTML) (6857 Views)
A case report of Hemoglobin Hamadan in
Hormozgan province
Soleimani H.1, Malekzadeh K.2, Shekari M.2, Paran F.1, Bazmjou M.1,
Namjou E.1, Jafari M.1
1Laboratory of Genetics and Prenatal Diagnosis, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Molecular Medicine Research Center of Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Abstract
Background and Objectives
β-thalassemia is the most common monogenic autosomal recessive all over the world. Therefore, identifying carriers and performing prenatal testing can prevent the birth of a new patient.
Case
The young couple resident in Bandar Abbas with their son were referred to the Genetic Laboratory with hematological parameters that indicated minor thalassemia and implicated a symptom of an unknown hemoglobin in the father. Based on the genetic study, the father carried a rare mutation in CD56 (GGC > CGC) leading to Hb-Hamadan.
Conclusions
In this study seems that Hb-Hamdan has no pathological effect and . This point is very important particularly in prenatal diagnosis (PND).
Key words: beta-Thalassemia, Hemoglobin, Prenatal Diagnosis
Received: 8 Dec 2013
Accepted: 11 Mar 2014
Correspondence: Malekzadeh K. PhD of Medical Biotechnology. Assistant Professor of Molecular Medicine Research Center, Hormozgan University of Medical Sciences.
P.O.Box: 79197-86848, Bandar Abbas, Iran. Tel: (+98761) 3354459; Fax: (+98761) 3354459
E-mail: keyanoosh@gmail.com
Full-Text: (3918 Views)
References:
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- Dinçol G, Aksoy M, Dinçol K, Kutlar A, Wilson JB, Huisman TH.. Hemoglobin Hamadan or alpha 2 beta-2 56(D7)Gly-Arg in a Turkish family. Hemoglobin 1984; 8(4): 423-5.
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Case Report
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Sci J Iran Blood Transfus Organ 2014; 11(3): 252-256 |
A case report of Hemoglobin Hamadan in
Hormozgan province
Soleimani H.1, Malekzadeh K.2, Shekari M.2, Paran F.1, Bazmjou M.1,
Namjou E.1, Jafari M.1
1Laboratory of Genetics and Prenatal Diagnosis, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Molecular Medicine Research Center of Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Abstract
Background and Objectives
β-thalassemia is the most common monogenic autosomal recessive all over the world. Therefore, identifying carriers and performing prenatal testing can prevent the birth of a new patient.
Case
The young couple resident in Bandar Abbas with their son were referred to the Genetic Laboratory with hematological parameters that indicated minor thalassemia and implicated a symptom of an unknown hemoglobin in the father. Based on the genetic study, the father carried a rare mutation in CD56 (GGC > CGC) leading to Hb-Hamadan.
Conclusions
In this study seems that Hb-Hamdan has no pathological effect and . This point is very important particularly in prenatal diagnosis (PND).
Key words: beta-Thalassemia, Hemoglobin, Prenatal Diagnosis
Received: 8 Dec 2013
Accepted: 11 Mar 2014
Correspondence: Malekzadeh K. PhD of Medical Biotechnology. Assistant Professor of Molecular Medicine Research Center, Hormozgan University of Medical Sciences.
P.O.Box: 79197-86848, Bandar Abbas, Iran. Tel: (+98761) 3354459; Fax: (+98761) 3354459
E-mail: keyanoosh@gmail.com
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