Volume 11, Issue 3 (Autumn 2014)                   Sci J Iran Blood Transfus Organ 2014, 11(3): 207-213 | Back to browse issues page

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Farsinejad A, Sarvar Azimzadeh B, Kazemzadeh S. Association between platelet collagen receptor polymorphisms with the risk of stroke in the middle-aged. Sci J Iran Blood Transfus Organ 2014; 11 (3) :207-213
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Sci J Iran Blood Transfus Organ 2014; 11(3): 207-213
 
Original  Article
 
 
 

Association between platelet collagen receptor
polymorphisms with the risk of stroke in the
middle-aged
 
Farsinejad A.R.1, Sarvar Azimzadeh B.2, Kazemzadeh Sh.3
 
 
 1Kerman University of Medical Sciences, Kerman, Iran
 2Physiology and Cardiovascular Research Center, Kerman University of Medical Sciences, Kerman, Iran
3Stem Cell Research and Application Center, Kerman University of Medical Sciences, Kerman, Iran
 
 
 
Abstract
Background and Objectives
Arterial thrombosis, with MI as the severe complication, represents the most frequent cause of death in the world. Although there is no doubt that genetic factors contribute significantly to the prothrombotic state, the data on polymorphisms in candidate genes are still inconclusive. We investigated if T13254C polymorphism in the platelet GPVI gene confers an increased risk of premature acute myocardial infarction (MI).
 
Materials and Methods
We conducted a case-control study of 100 young males with premature acute MI and 100  inpatient controls of the similar age, without any known heart diseases. Genotyping was done using PCR-RFLP. The significance of differences between cases and controls with respect to the variables was tested using student’s t test and Chi square. Logical regression model was used to control confounding variables.
 
Results
The allele frequencies of T13254C polymorphism did not differ between patients (30%) and controls (33%), and this polymorphism was not associated with premature acute MI (p < 0.05). Logistic regression analysis also indicated no association between these polymorphisms and premature MI.
 
Conclusions
Compatible with our study, the T13254C polymorphism of platelet collagen receptor did not play a significant role in the development of premature MI.
 
Key words: Myocardial Infarction, Genetic Polymorphisms, Platelets
 
 
 
 
 
 
Received: 19 Nov 2013
Accepted:   7 Jan 2014
 
 

 

Correspondence: Farsinejad A., PhD of Hematology and Blood Banking. Assistant Professor of Kerman University of Medical Sciences.
P.O.Box: 76175584, Kerman, Iran. Tel: (+98341) 3222212; Fax: (+98341) 3224618
E-mail: farsinezhad239@yahoo.com
Type of Study: Research | Subject: Hematology
Published: 2014/09/27

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