Volume 10, Issue 3 (Autumn 2013)                   Sci J Iran Blood Transfus Organ 2013, 10(3): 231-238 | Back to browse issues page

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Pazoukian M, Sharifi Z, Pourfatholah A, Hamidpour M, Sanei Moghaddam E, Khosravi S. Investigation of anti-HBc and anti-HBs prevalence in HBsAg negative blood donors in Sistan-o-Baluchestan province. Sci J Iran Blood Transfus Organ 2013; 10 (3) :231-238
URL: http://bloodjournal.ir/article-1-792-en.html
Investigation of anti-HBc and anti-HBs prevalence in HBsAg negative blood donors in Sistan-o-Baluchestan province
M. Pazoukian , Z. Sharifi * , A.A Pourfatholah , M. Hamidpour , E. Sanei Moghaddam , S. Khosravi
Keywords: Hepatitis B, Hepatitis C, Blood Donors
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References : 
  1. Kafi-abad SA, Rezvan H, Abolghasemi H. Trends in prevalence of hepatitis B virus infection among Iranian blood donors, 1998-2007. Transfus Med 2009; 19(4): 189-94.
  2. Alavian M. Hepatitis B virus infection in Iran; Changing the epidemiology. Iranian Journal of Clinical Infectious Diseases 2010; 5(1): 51-61.
  3. Songle H, Xuan NT, Toan NL, Binh VQ, Boldt AB, Kremsner PG, et al. Association of two variants of the interferon-alpha receptor-1 gene with the presentation of hepatitis B virus infection. Eur Cytokine Netw 2008; 19(4): 204-10.
  4. Candotti D, Chaar M.EI, Allain JP. Transfusion transmission of hepatitis B virus: still learning more about it. ISBT Science Series 2011; 6(1): 234-40.
  5. Zhang JM, Xu Y, Wang XY, Yin YK, Wu XH, Weng XH, et al. Coexistence of hepatitis B surface antigen (HBsAg) and heterologous subtype-specific antibodies
 
 
 
 
to HBsAg among patients with chronic hepatitis B virus infection. Clin Infect Dis 2007; 44(9): 1161-9.
  1. Weber B. Genetic variability of the S gene of hepatitis B virus: clinical and diagnostic impact. J Clin Virol 2005; 32(2): 102-12.
  2. El Chaar M, Candotti D, Crowther RA, Allain JP. Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection. Hepatology 2010; 52(5): 1600-10.
  3. Bordea M, Teleianu C, Popamare A, Vacariu A, Stan C, Iliescu I. Immune mechanisms in the process of hepatopathies chronicization. Contribution and role of lymphokines. Rom J Physiol 1995; 32(1-4): 87-95.
  4. Candotti D, Allain JP. Transfusion-transmitted hepatitis B virus infection. J Hepatol 2009; 51(4): 798-809.
  5. Kleinman SH, Busch MP. HBV: amplified and back in the  blood  safety  spotlight.  Transfusion  2001;  41(9):
1081-5.
  1. Sato S, Ohhashi W, Ihara H, Sakaya S, Kato T, Ikeda H. Comparison of the sensitivity of NAT using pooled donor samples for HBV and that of a serologic HBsAg assay. Transfusion 2001; 41(9): 1107-13.
  2. Chen DS. From hepatitis to hepatoma: Lessons from type B viral hepatitis. Science 1993; 262(5132): 369-70.
  3. Sharifi-Mood B, Sanei-Moghaddam E, Ghasem-Zadeh I, Khosravi S. Occult hepatitis B virus infection among anti-HBc only positive individuals in the Southeast of Iran in high prevalence of HBV infection region. Iran Red Crescent Med J 2009; 11(1): 90-2.
  4. Salehi M, Sanei-Moghaddam E, Khosravi S. Seroepidemiological study of HBV and HCV infection in the total population of Zahedan region, Iran.
    Zahedan Journal of Research in Medical Sciences 2005; 1: 63-9. [Article in Farsi]
  5. Alizadeh Z, Sharifi Z, Samiei Sh. Prevalence of anti-HBc and anti-HBs in HBsAg negative. Sci J Iran Blood Transfus Organ 2008; 5(3): 139-47. [Article in Farsi]
  6. Manzini P, Girotto M, Borsotti R, Giachino O, Guaschino R, Lanteri M, et al. Italian blood donors with anti-HBc and occult hepatitis B virus infection. Haematologica 2007; 92(12): 1664-70.
  7. Allain JP. Occult hepatitis B virus infection: implications in transfusion. Vox Sang 2004; 86(2): 83-91.
  8. Allain JP, Hewitt PE, Tedder RS, Williamson LM. Evidence that anti-HBc but not HBV DNA testing may prevent some HBV transmission by transfusion. Br J Haematol 1999; 107(1): 186-95.
 
 
 
 
 
 
 

 
 
Original Article
 
 
 
 
Sci J Iran Blood Transfus Organ 2013; 10(3): 231-238
 
 

 

Investigation of anti-HBc and anti-HBs prevalence
in HBsAg negative blood donors in
Sistan-o-Baluchestan province
 
Pazoukian M.1,2, Sharifi Z.1, Pourfathollah A.A.3, Hamidpour M.2,
Sanei Moghaddam E.1,4, Khosravi S.1,4   
 
 
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion  Medicine, Tehran, Iran
2Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4Zahedan Regional Educational Blood Transfusion Center, Zahedan, Iran
 
 
Abstract
Background and Objectives
The most common marker used for HBV infection diagnosis in blood donors is screening for HBsAg. The failure of HBsAg detection in blood donors cause of either the window period, or the mutation in S gene, or the reduction in the antigen synthesis can lead to transfusion-transmitted HBV in blood recipients. There have been reported hepatitis cases following the transfusion of anti-HBc positive blood and blood components. The prevalence of anti-HBc in populations is proportional to the prevalence of HBsAg. It is better then for studies about the prevalence of anti-HBc to be conducted in HBV highly prevalent regions. Thus, the aim of this study was to survey anti-HBc and anti-HBs prevalence rates in blood donors in Sistan-o-Baluchestan.
 
Materials and Methods
In this cross-sectional study, 1500 HBsAg negative samples were collected from Sistan-o-Baluchestan and tested for anti-HBc. All anti-HBc positive samples were tested for anti-HBs. All data were analyzed statistically using Chi-square test.
 
Results
Out of 1500 blood donors who were negative for HBsAg, 144 (9.6%) were positive for anti-HBc with 74.3% having the immunity titer of anti-HBs.
 
Conclusions
In this study, the prevalence rate of anti-HBc was very high. Most of anti-HBc positive blood donors were positive for anti-HBs. Therefore, screening of blood donors for anti-HBc can limit the storage of blood.
 
Key words:  Hepatitis B, Hepatitis C, Blood Donors
 
 
Received : 28 Apr 2012
Accepted: 13 Oct 2012
 
 
 

Correspondence: Sharifi Z., PhD of Virology. Associate Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 82052229; Fax: (+9821) 88601555
E-mail:
z.sharifi@ibto.ir
Type of Study: Research | Subject: Infectious disease
Published: 2013/10/5
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