Volume 22, Issue 3 (Autumn 2025)
bloodj 2025, 22(3): 196-205 |
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Ethics code: IR.UMSHA.REC.1401.097
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Amiri F, Akbari H, Afshari A, salimi R. Patterns of Acute Blood Component Transfusion Reactions in a Hamadan Educational Hospital Inpatients in 3-Years. bloodj 2025; 22 (3) :196-205
URL: http://bloodjournal.ir/article-1-1598-en.html
URL: http://bloodjournal.ir/article-1-1598-en.html
Abstract: (146 Views)
A B S T R A C T
Background and Objectives
Blood transfusion-related reactions are predominantly undesirable immune-mediated responses that occur in recipients following the administration of blood and blood components. Some of these reactions are acute and may result in severe symptoms or even patient mortality. Timely detecting of transfusion reactions is critical for reducing their incidence and associated risks. This study aimed to identify and analyze acute blood transfusion reactions at Besat hospital Hamadan from 2019 to 2021.
Materials and Methods
This retrospective cross-sectional study reviewed the medical records of 428 inpatients who had blood transfusion reaction after receiving blood components. The data was extracted from patient files and hospital’s hemovigilance office. Statistical analysis was performed by SPSS software version 24, using independent-t and chi square tests.
Results
The mean age of the patients was 45.33 years of total participants. 299 (53.5%) were male and 199 (46.5%) were female. The average number of transfused blood component per patient was 2.65. A history of blood component transfusion was reported in 56 patients (13.1%), while 372 patients (86.9%) had no prior transfusion history. Among the transfused components, 64.2% were cellular and 35.8% were plasma components. Febrile non-hemolytic transfusion reaction (FNHTR) occured in 42.15% of cases, and Allergic reactions were observed in 38.56%, were more common than other reactions. There was a significant relationship between patient age and the occurrence of FNHTR (p= 0.020), allergic reactions (p= 0.019), transfusion-related hypotension (p= 0.001) and transfusion- related dyspnea (p= 0.010). Totally, the incidence of reactions was significantly related to the number of transfused blood components (p= 0.030). Additionally, transfusion of cellular blood components was associated with a higher rate of reactions compared to plasma components (p= 0.018).
Conclusions
The most fequently reported reaction was FNHTR. There was significant associations between patient age, the number and type of transfused components and the occurrence of specific reactions. These results highlight the importance of careful evaluation and monitoring of blood transfusion requests, particularly in elderly patients, with attention to both the quantity and type of blood components administered.
Background and Objectives
Blood transfusion-related reactions are predominantly undesirable immune-mediated responses that occur in recipients following the administration of blood and blood components. Some of these reactions are acute and may result in severe symptoms or even patient mortality. Timely detecting of transfusion reactions is critical for reducing their incidence and associated risks. This study aimed to identify and analyze acute blood transfusion reactions at Besat hospital Hamadan from 2019 to 2021.
Materials and Methods
This retrospective cross-sectional study reviewed the medical records of 428 inpatients who had blood transfusion reaction after receiving blood components. The data was extracted from patient files and hospital’s hemovigilance office. Statistical analysis was performed by SPSS software version 24, using independent-t and chi square tests.
Results
The mean age of the patients was 45.33 years of total participants. 299 (53.5%) were male and 199 (46.5%) were female. The average number of transfused blood component per patient was 2.65. A history of blood component transfusion was reported in 56 patients (13.1%), while 372 patients (86.9%) had no prior transfusion history. Among the transfused components, 64.2% were cellular and 35.8% were plasma components. Febrile non-hemolytic transfusion reaction (FNHTR) occured in 42.15% of cases, and Allergic reactions were observed in 38.56%, were more common than other reactions. There was a significant relationship between patient age and the occurrence of FNHTR (p= 0.020), allergic reactions (p= 0.019), transfusion-related hypotension (p= 0.001) and transfusion- related dyspnea (p= 0.010). Totally, the incidence of reactions was significantly related to the number of transfused blood components (p= 0.030). Additionally, transfusion of cellular blood components was associated with a higher rate of reactions compared to plasma components (p= 0.018).
Conclusions
The most fequently reported reaction was FNHTR. There was significant associations between patient age, the number and type of transfused components and the occurrence of specific reactions. These results highlight the importance of careful evaluation and monitoring of blood transfusion requests, particularly in elderly patients, with attention to both the quantity and type of blood components administered.
Type of Study: Research |
Subject:
Blood Transfusion
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