[Home ] [Archive]   [ فارسی ]  
:: Main :: About us :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Advisory Board
Aims & Scope
Journal News
Articles archive::
All Issues
Current Issue
Articles in press
For Authors::
Submission Instruction
For Reviewers::
Reviewers Section
Subscription::
Subscription Form
News& Events::
Journal News
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
Top 10 contents
Inform others
Ethics & Permissions::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing
                        
..
:: Volume 21, Issue 3 (Autumn 2024) ::
Sci J Iran Blood Transfus Organ 2024, 21(3): 254-267 Back to browse issues page
Hemostatic materials based on natural polymers
A. Eslahi kalurazi , M. Shahrousvand , S.M. Davachi , J. Mohammadi-Rovshandeh , M.R. Mobayen
Keywords: Key words: Blood Clot, Wounds, Polymers, Coagulant, Bleeding, Chitosan, Starch, Alginate ​​​​​​​
Full-Text [PDF 954 kb]   (117 Downloads)     |   Abstract (HTML)  (238 Views)
Type of Study: Review Article | Subject: Biomedical Engineering
Published: 2024/10/1
Full-Text:   (313 Views)
References:
  1. Cheng F, He J, Yan T, Liu C, Wei X, Li J, et al. Antibacterial and hemostatic composite gauze of N, O-carboxymethyl chitosan/oxidized regenerated cellulose. RSC Advances 2016; 6(97): 94429-36.
  2. Zheng C, Zeng Q, Pimpi S, Wu W, Han K, Dong K, et al. Research status and development potential of composite hemostatic materials. J Mater Chem B 2020; 8(25): 5395-410.
  3. Zarei R, Mirmasoudi SS, Feizkhah A, Pourmohammadi Bejarpasi Z, Shahrousvand M. The Optimizing Process of the Blood Coagulation Powder Composition With Response Surface Methodology. Computational Sciences and Engineering 2022; 2(2): 311-22.
  4. Aghajan MH, Panahi-Sarmad M, Alikarami N, Shojaei S, Saeidi A, Khonakdar HA, et al. Using solvent-free approach for preparing innovative biopolymer nanocomposites based on PGS/gelatin. European Polymer Journal 2020; 131: 109720.
  1. Nowroozi N, Faraji S, Nouralishahi A, Shahrousvand M. Biological and structural properties of graphene oxide/curcumin nanocomposite incorporated chitosan as a scaffold for wound healing application. Life Sci 2021; 264: 118640.
  2. Fazil M, Nikhat S. Topical medicines for wound healing: A systematic review of Unani literature with recent advances. J Ethnopharmacol 2020; 257: 112878.
  3. Shahrousvand M, Ebrahimi NG, Oliaie H, Heydari M, Mir M, Shahrousvand M. Chapter 4- Polymeric transdermal drug delivery systems.  In: Modeling and Control of Drug Delivery Systems. Philadelphia: Academic Press; 2021. p. 45-65.
  4. Achneck HE, Sileshi B, Jamiolkowski RM, Albala DM, Shapiro ML, Lawson JH. A comprehensive review of topical hemostatic agents: efficacy and recommendations for use. Ann Surg 2010; 251(2): 217-28.
  5. Pereira BM, Bortoto JB, Fraga GP. Topical hemostatic agents in surgery: review and prospects. Rev Col Bras Cir 2018; 45(5): e1900.
  6. Yadav C, Saini A, Maji P. Cellulose nanofibres as biomaterial for nano-reinforcement of poly[styrene-(ethylene-co-butylene)-styrene] triblock copolymer. Cellulose 2018; 25: 1-13.
  7. Lai C, Zhang S, Chen X, Sheng LY. Nanocomposite films based on TEMPO-mediated oxidized bacterial cellulose and chitosan. Cellulose 2014; 21: 2757-72.
  8. Keshavarzi S, MacDougall M, Lulic D, Kasasbeh A, Levy M. Clinical experience with the surgicel family of absorbable hemostats (oxidized regenerated cellulose) in neurosurgical applications: a review. Wounds 2013; 25(6): 160-7.
  9. Wu YD, He JM, Huang YD, Wang FW, Tang F. Oxidation of regenerated cellulose with nitrogen dioxide/carbon tetrachloride. Fibers and Polymers 2012; 13(5): 576-81.
  10. Queirós E, Pinheiro S, Pereira J, Prada J, Pires I, Dourado F, et al. Hemostatic dressings made of oxidized bacterial nanocellulose membranes. Polysaccharides 2021; 2(1): 80-99.
  11. Nguyen THM, Abueva C, Ho HV, Lee SY, Lee BT. In vitro and in vivo acute response towards injectable thermosensitive chitosan/TEMPO-oxidized cellulose nanofiber hydrogel. Carbohydr Polym 2018; 180: 246-55.
  12. Shefa AA, Amirian J, Kang HJ, Bae SH, Jung HI, Choi HJ, et al. In vitro and in vivo evaluation of effectiveness of a novel TEMPO-oxidized cellulose nanofiber-silk fibroin scaffold in wound healing. Carbohydr Polym 2017; 177: 284-96.
  13. Liu R, Dai L, Si C, Zeng Z. Antibacterial and hemostatic hydrogel via nanocomposite from cellulose nanofibers. Carbohydr Polym 2018; 195: 63-70.
  14. Shefa AA, Taz M, Hossain M, Kim YS, Lee SY, Lee BT. Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding. Int J Biol Macromol 2019; 126: 786-95.
  15. Jin H, Wang Z. Advances in Alkylated Chitosan and Its Applications for Hemostasis. Macromol 2022; 2(3): 346-60.
  16. Mohammadi Sadati SM, Shahgholian-Ghahfarrokhi N, Shahrousvand E, Mohammadi-Rovshandeh J, Shahrousvand M. Edible chitosan/cellulose nanofiber nanocomposite films for potential use as food packaging. Materials Technology 2022; 37(10): 1276-88.
  17. Lim C, Lee DW, Israelachvili JN, Jho Y, Hwang DS. Contact time-and pH-dependent adhesion and cohesion of low molecular weight chitosan coated surfaces. Carbohydr Polym 2015; 117: 887-94.
  18. Song F, Kong Y, Shao C, Cheng Y, Lu J, Tao Y, et al. Chitosan-based multifunctional flexible hemostatic bio-hydrogel. Acta Biomater 2021; 136: 170-83.
  19. Peng X, Xia X, Xu X, Yang X, Yang B, Zhao P, et al. Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations. Sci Adv 2021; 7(23): eabe8739.
  20. Peng X, Xu X, Deng Y, Xie X, Xu L, Xu X, et al. Ultrafast self‐gelling and wet adhesive powder for acute hemostasis and wound healing. Advanced Functional Materials 2021; 31(33): 2102583.
  21. Whistler RL, BeMiller JN, Paschall EF. Starch: chemistry and technology. Philadelphia: Academic Press. 2012; p. 100-5.
  22. Horstmann SW, Lynch KM, Arendt EK. Starch Characteristics Linked to Gluten-Free Products. Foods 2017; 6(4): 29.
  23. Yari S, Mohammadi-Rovshandeh J, Shahrousvand M. Preparation and Optimization of Starch/Poly Vinyl Alcohol/ZnO Nanocomposite Films Applicable for Food Packaging. Journal of Polymers and the Environment 2022; 30(4): 1502-17.
  24. Visakh PM, Mathew AP, Oksman K, Thomas S. Chapter 11- Starch-Based Bionanocomposites: Processing and Properties. In: Habibi Y, Lucia LA. Polysaccharide Building Blocks: A Sustainable Approach to the Development of Renewable Biomaterials. 1st ed. USA: Wiley; 2014. p. 300-54.
  25. Yu J, Su H, Wei S, Chen F, Liu C. Calcium content mediated hemostasis of calcium-modified oxidized microporous starch. J Biomater Sci Polym Ed 2018; 29(14): 1716-28.
  26. Chen X, Yan Y, Li H, Wang X, Tang S, Li Q, et al. Evaluation of absorbable hemostatic agents of polyelectrolyte complexes using carboxymethyl starch and chitosan oligosaccharide both in vitro and in vivo. Biomater Sci 2018; 6(12): 3332-44.
  27. Zheng C, Bai Q, Wu W, Han K, Zeng Q, Dong K, et al. Study on hemostatic effect and mechanism of starch-based nano-microporous particles. Int J Biol Macromol 2021; 179: 507-18.
  28. Huang W, Wu J, Huang Z, Zhang D, Chen F, Liu C. A self-gelling starch-based sponge for hemostasis. J Mater Chem B 2023; 11(6): 1331-43.
  29. San Antonio JD, Jacenko O, Fertala A, Orgel JPRO. Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine. Bioengineering 2021; 8(1): 3.
  30. Chen J, Gao K, Liu S, Wang S, Elango J, Bao B, et al. Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo. Mar Drugs 2019; 17(1): 33.
  31. Manon-Jensen T, Kjeld NG, Karsdal MA. Collagen-mediated hemostasis. J Thromb Haemost 2016; 14(3): 438-48.
  32. Werz W, Hoffmann H, Haberer K, Walter JK. Strategies to avoid virus transmissions by biopharmaceutic products. Arch Virol Suppl 1997; 13: 245-56.
  33. Wang L, Li W, Qu Y, Wang K, Lv K, He X, et al. Preparation of super absorbent and highly active fish collagen sponge and its hemostatic effect in vivo and in vitro. Front Bioeng Biotechnol 2022; 10: 862532.
  34. He Y, Wang J, Si Y, Wang X, Deng H, Sheng Z, et al. A novel gene recombinant collagen hemostatic sponge with excellent biocompatibility and hemostatic effect. Int J Biol Macromol 2021; 178: 296-305.
  35. Snelgrove PV. An ocean of discovery: Biodiversity beyond the census of marine life. Planta Med 2016; 82(09/10): 790-9.
  36. Sellimi S, Younes I, Ayed HB, Maalej H, Montero V, Rinaudo M, et al. Structural, physicochemical and antioxidant properties of sodium alginate isolated from a Tunisian brown seaweed. Int J Biol Macromol 2015; 72: 1358-67.
  37. Xie Y, Gao P, He F, Zhang C. Application of Alginate-Based Hydrogels in Hemostasis. Gels 2022; 8(2): 109.
  38. Ouyang XK, Zhao L, Jiang F, Ling J, Yang LY, Wang N. Cellulose nanocrystal/calcium alginate-based porous microspheres for rapid hemostasis and wound healing. Carbohydr Polym 2022; 293: 119688.
  39. Zhai Z, Xu K, Mei L, Wu C, Liu J, Liu Z, et al. Co-assembled supramolecular hydrogels of cell adhesive peptide and alginate for rapid hemostasis and efficacious wound healing. Soft Matter 2019; 15(42): 8603-10.
  40. Shahrousvand E, Shahrousvand M. Preparation of polyurethane/poly (2-hydroxyethyl methacrylate) semi-IPNs containing cellulose nanocrystals for biomedical applications. Materials Today Communications 2021; 27: 102421.
  41. Huang TY, Shahrousvand M, Hsu YT, Su WT. Polycaprolactone/Polyethylene Glycol Blended with Dipsacus asper Wall Extract Nanofibers Promote Osteogenic Differentiation of Periodontal Ligament Stem Cells. Polymers (Basel) 2021; 13(14): 2245.
  42. Ghimire S, Sarkar P, Rigby K, Maan A, Mukherjee S, Crawford KE, et al. Polymeric Materials for Hemostatic Wound Healing. Pharmaceutics 2021; 13(12): 2127.
  43. Chen Z, Han L, Liu C, Du Y, Hu X, Du G, et al. A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and N-alkylated chitosan. Nanoscale 2018; 10(43): 20234-45.
  44. Chan LW, Kim CH, Wang X, Pun SH, White NJ, Kim TH. PolySTAT-modified chitosan gauzes for improved hemostasis in external hemorrhage. Acta Biomater 2016; 31: 178-85.
  45. Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, et al. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nat Commun 2019; 10(1): 2060.
  46. Huang Y, Zhao X, Zhang Z, Liang Y, Yin Z, Chen B, et al. Degradable gelatin-based IPN cryogel hemostat for rapidly stopping deep noncompressible hemorrhage and simultaneously improving wound healing. Chemistry of Materials 2020; 32(15): 6595-610.
  47. Singh RK, Baumgartner B, Mantei JR, Parreno RN, Sanders PJ, Lewis KM, et al. Hemostatic comparison of a polysaccharide powder and a gelatin powder. J Invest Surg 2018; 32(5): 393-401.
  48. Bang B, Lee E, Maeng J, Kim K, Hwang JH, Hyon SH, et al. Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model. PLoS One 2019; 14(6): e0216829.
  49. Gouranlou F, Ziveh T. Review on Effect of Hemorrhages in Rescuing Casualties from Fatalities. Journal of Shahid Sadoughi University of Medical Sciences 2020; 28(8): 2905-21. [Article in Farsi]
  50. Burnett LR, Richter JG, Rahmany MB, Soler R, Steen JA, Orlando G, et al. Novel keratin (KeraStat™) and polyurethane (Nanosan(R)-Sorb) biomaterials are hemostatic in a porcine lethal extremity hemorrhage model. J Biomater Appl 2014; 28(6): 869-79.
  51. Kozen BG, Kircher SJ, Henao J, Godinez FS, Johnson AS. An alternative hemostatic dressing: comparison of CELOX, HemCon, and QuikClot. Acad Emerg Med 2008; 15(1): 74-81.

References:
  1. Cheng F, He J, Yan T, Liu C, Wei X, Li J, et al. Antibacterial and hemostatic composite gauze of N, O-carboxymethyl chitosan/oxidized regenerated cellulose. RSC Advances 2016; 6(97): 94429-36.
  2. Zheng C, Zeng Q, Pimpi S, Wu W, Han K, Dong K, et al. Research status and development potential of composite hemostatic materials. J Mater Chem B 2020; 8(25): 5395-410.
  3. Zarei R, Mirmasoudi SS, Feizkhah A, Pourmohammadi Bejarpasi Z, Shahrousvand M. The Optimizing Process of the Blood Coagulation Powder Composition With Response Surface Methodology. Computational Sciences and Engineering 2022; 2(2): 311-22.
  4. Aghajan MH, Panahi-Sarmad M, Alikarami N, Shojaei S, Saeidi A, Khonakdar HA, et al. Using solvent-free approach for preparing innovative biopolymer nanocomposites based on PGS/gelatin. European Polymer Journal 2020; 131: 109720.
  1. Nowroozi N, Faraji S, Nouralishahi A, Shahrousvand M. Biological and structural properties of graphene oxide/curcumin nanocomposite incorporated chitosan as a scaffold for wound healing application. Life Sci 2021; 264: 118640.
  2. Fazil M, Nikhat S. Topical medicines for wound healing: A systematic review of Unani literature with recent advances. J Ethnopharmacol 2020; 257: 112878.
  3. Shahrousvand M, Ebrahimi NG, Oliaie H, Heydari M, Mir M, Shahrousvand M. Chapter 4- Polymeric transdermal drug delivery systems.  In: Modeling and Control of Drug Delivery Systems. Philadelphia: Academic Press; 2021. p. 45-65.
  4. Achneck HE, Sileshi B, Jamiolkowski RM, Albala DM, Shapiro ML, Lawson JH. A comprehensive review of topical hemostatic agents: efficacy and recommendations for use. Ann Surg 2010; 251(2): 217-28.
  5. Pereira BM, Bortoto JB, Fraga GP. Topical hemostatic agents in surgery: review and prospects. Rev Col Bras Cir 2018; 45(5): e1900.
  6. Yadav C, Saini A, Maji P. Cellulose nanofibres as biomaterial for nano-reinforcement of poly[styrene-(ethylene-co-butylene)-styrene] triblock copolymer. Cellulose 2018; 25: 1-13.
  7. Lai C, Zhang S, Chen X, Sheng LY. Nanocomposite films based on TEMPO-mediated oxidized bacterial cellulose and chitosan. Cellulose 2014; 21: 2757-72.
  8. Keshavarzi S, MacDougall M, Lulic D, Kasasbeh A, Levy M. Clinical experience with the surgicel family of absorbable hemostats (oxidized regenerated cellulose) in neurosurgical applications: a review. Wounds 2013; 25(6): 160-7.
  9. Wu YD, He JM, Huang YD, Wang FW, Tang F. Oxidation of regenerated cellulose with nitrogen dioxide/carbon tetrachloride. Fibers and Polymers 2012; 13(5): 576-81.
  10. Queirós E, Pinheiro S, Pereira J, Prada J, Pires I, Dourado F, et al. Hemostatic dressings made of oxidized bacterial nanocellulose membranes. Polysaccharides 2021; 2(1): 80-99.
  11. Nguyen THM, Abueva C, Ho HV, Lee SY, Lee BT. In vitro and in vivo acute response towards injectable thermosensitive chitosan/TEMPO-oxidized cellulose nanofiber hydrogel. Carbohydr Polym 2018; 180: 246-55.
  12. Shefa AA, Amirian J, Kang HJ, Bae SH, Jung HI, Choi HJ, et al. In vitro and in vivo evaluation of effectiveness of a novel TEMPO-oxidized cellulose nanofiber-silk fibroin scaffold in wound healing. Carbohydr Polym 2017; 177: 284-96.
  13. Liu R, Dai L, Si C, Zeng Z. Antibacterial and hemostatic hydrogel via nanocomposite from cellulose nanofibers. Carbohydr Polym 2018; 195: 63-70.
  14. Shefa AA, Taz M, Hossain M, Kim YS, Lee SY, Lee BT. Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding. Int J Biol Macromol 2019; 126: 786-95.
  15. Jin H, Wang Z. Advances in Alkylated Chitosan and Its Applications for Hemostasis. Macromol 2022; 2(3): 346-60.
  16. Mohammadi Sadati SM, Shahgholian-Ghahfarrokhi N, Shahrousvand E, Mohammadi-Rovshandeh J, Shahrousvand M. Edible chitosan/cellulose nanofiber nanocomposite films for potential use as food packaging. Materials Technology 2022; 37(10): 1276-88.
  17. Lim C, Lee DW, Israelachvili JN, Jho Y, Hwang DS. Contact time-and pH-dependent adhesion and cohesion of low molecular weight chitosan coated surfaces. Carbohydr Polym 2015; 117: 887-94.
  18. Song F, Kong Y, Shao C, Cheng Y, Lu J, Tao Y, et al. Chitosan-based multifunctional flexible hemostatic bio-hydrogel. Acta Biomater 2021; 136: 170-83.
  19. Peng X, Xia X, Xu X, Yang X, Yang B, Zhao P, et al. Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations. Sci Adv 2021; 7(23): eabe8739.
  20. Peng X, Xu X, Deng Y, Xie X, Xu L, Xu X, et al. Ultrafast self‐gelling and wet adhesive powder for acute hemostasis and wound healing. Advanced Functional Materials 2021; 31(33): 2102583.
  21. Whistler RL, BeMiller JN, Paschall EF. Starch: chemistry and technology. Philadelphia: Academic Press. 2012; p. 100-5.
  22. Horstmann SW, Lynch KM, Arendt EK. Starch Characteristics Linked to Gluten-Free Products. Foods 2017; 6(4): 29.
  23. Yari S, Mohammadi-Rovshandeh J, Shahrousvand M. Preparation and Optimization of Starch/Poly Vinyl Alcohol/ZnO Nanocomposite Films Applicable for Food Packaging. Journal of Polymers and the Environment 2022; 30(4): 1502-17.
  24. Visakh PM, Mathew AP, Oksman K, Thomas S. Chapter 11- Starch-Based Bionanocomposites: Processing and Properties. In: Habibi Y, Lucia LA. Polysaccharide Building Blocks: A Sustainable Approach to the Development of Renewable Biomaterials. 1st ed. USA: Wiley; 2014. p. 300-54.
  25. Yu J, Su H, Wei S, Chen F, Liu C. Calcium content mediated hemostasis of calcium-modified oxidized microporous starch. J Biomater Sci Polym Ed 2018; 29(14): 1716-28.
  26. Chen X, Yan Y, Li H, Wang X, Tang S, Li Q, et al. Evaluation of absorbable hemostatic agents of polyelectrolyte complexes using carboxymethyl starch and chitosan oligosaccharide both in vitro and in vivo. Biomater Sci 2018; 6(12): 3332-44.
  27. Zheng C, Bai Q, Wu W, Han K, Zeng Q, Dong K, et al. Study on hemostatic effect and mechanism of starch-based nano-microporous particles. Int J Biol Macromol 2021; 179: 507-18.
  28. Huang W, Wu J, Huang Z, Zhang D, Chen F, Liu C. A self-gelling starch-based sponge for hemostasis. J Mater Chem B 2023; 11(6): 1331-43.
  29. San Antonio JD, Jacenko O, Fertala A, Orgel JPRO. Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine. Bioengineering 2021; 8(1): 3.
  30. Chen J, Gao K, Liu S, Wang S, Elango J, Bao B, et al. Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo. Mar Drugs 2019; 17(1): 33.
  31. Manon-Jensen T, Kjeld NG, Karsdal MA. Collagen-mediated hemostasis. J Thromb Haemost 2016; 14(3): 438-48.
  32. Werz W, Hoffmann H, Haberer K, Walter JK. Strategies to avoid virus transmissions by biopharmaceutic products. Arch Virol Suppl 1997; 13: 245-56.
  33. Wang L, Li W, Qu Y, Wang K, Lv K, He X, et al. Preparation of super absorbent and highly active fish collagen sponge and its hemostatic effect in vivo and in vitro. Front Bioeng Biotechnol 2022; 10: 862532.
  34. He Y, Wang J, Si Y, Wang X, Deng H, Sheng Z, et al. A novel gene recombinant collagen hemostatic sponge with excellent biocompatibility and hemostatic effect. Int J Biol Macromol 2021; 178: 296-305.
  35. Snelgrove PV. An ocean of discovery: Biodiversity beyond the census of marine life. Planta Med 2016; 82(09/10): 790-9.
  36. Sellimi S, Younes I, Ayed HB, Maalej H, Montero V, Rinaudo M, et al. Structural, physicochemical and antioxidant properties of sodium alginate isolated from a Tunisian brown seaweed. Int J Biol Macromol 2015; 72: 1358-67.
  37. Xie Y, Gao P, He F, Zhang C. Application of Alginate-Based Hydrogels in Hemostasis. Gels 2022; 8(2): 109.
  38. Ouyang XK, Zhao L, Jiang F, Ling J, Yang LY, Wang N. Cellulose nanocrystal/calcium alginate-based porous microspheres for rapid hemostasis and wound healing. Carbohydr Polym 2022; 293: 119688.
  39. Zhai Z, Xu K, Mei L, Wu C, Liu J, Liu Z, et al. Co-assembled supramolecular hydrogels of cell adhesive peptide and alginate for rapid hemostasis and efficacious wound healing. Soft Matter 2019; 15(42): 8603-10.
  40. Shahrousvand E, Shahrousvand M. Preparation of polyurethane/poly (2-hydroxyethyl methacrylate) semi-IPNs containing cellulose nanocrystals for biomedical applications. Materials Today Communications 2021; 27: 102421.
  41. Huang TY, Shahrousvand M, Hsu YT, Su WT. Polycaprolactone/Polyethylene Glycol Blended with Dipsacus asper Wall Extract Nanofibers Promote Osteogenic Differentiation of Periodontal Ligament Stem Cells. Polymers (Basel) 2021; 13(14): 2245.
  42. Ghimire S, Sarkar P, Rigby K, Maan A, Mukherjee S, Crawford KE, et al. Polymeric Materials for Hemostatic Wound Healing. Pharmaceutics 2021; 13(12): 2127.
  43. Chen Z, Han L, Liu C, Du Y, Hu X, Du G, et al. A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and N-alkylated chitosan. Nanoscale 2018; 10(43): 20234-45.
  44. Chan LW, Kim CH, Wang X, Pun SH, White NJ, Kim TH. PolySTAT-modified chitosan gauzes for improved hemostasis in external hemorrhage. Acta Biomater 2016; 31: 178-85.
  45. Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, et al. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nat Commun 2019; 10(1): 2060.
  46. Huang Y, Zhao X, Zhang Z, Liang Y, Yin Z, Chen B, et al. Degradable gelatin-based IPN cryogel hemostat for rapidly stopping deep noncompressible hemorrhage and simultaneously improving wound healing. Chemistry of Materials 2020; 32(15): 6595-610.
  47. Singh RK, Baumgartner B, Mantei JR, Parreno RN, Sanders PJ, Lewis KM, et al. Hemostatic comparison of a polysaccharide powder and a gelatin powder. J Invest Surg 2018; 32(5): 393-401.
  48. Bang B, Lee E, Maeng J, Kim K, Hwang JH, Hyon SH, et al. Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model. PLoS One 2019; 14(6): e0216829.
  49. Gouranlou F, Ziveh T. Review on Effect of Hemorrhages in Rescuing Casualties from Fatalities. Journal of Shahid Sadoughi University of Medical Sciences 2020; 28(8): 2905-21. [Article in Farsi]
  50. Burnett LR, Richter JG, Rahmany MB, Soler R, Steen JA, Orlando G, et al. Novel keratin (KeraStat™) and polyurethane (Nanosan(R)-Sorb) biomaterials are hemostatic in a porcine lethal extremity hemorrhage model. J Biomater Appl 2014; 28(6): 869-79.
  51. Kozen BG, Kircher SJ, Henao J, Godinez FS, Johnson AS. An alternative hemostatic dressing: comparison of CELOX, HemCon, and QuikClot. Acad Emerg Med 2008; 15(1): 74-81.





 



Sci J Iran Blood Transfus Organ 2024; 21 (3): 254-267
Review Article
 






Hemostatic materials based on natural polymers

Eslahi kalurazi A.1, Shahrousvand M.1, Davachi S.M.2,
Mohammadi-Rovshandeh J.1, Mobayen M.R.3


1Caspian Faculty of Engineering, College of Engineering, University of Tehran, Rezvanshahr, Iran
2Department of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA
3Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran


Abstract
Background and Objectives
Bleeding agents play a vital role in preventing complications from uncontrolled bleeding, such as death and organ damage. In addition to maximum coagulation speed and minimal blood loss, these compounds should have features such as biocompatibility, degradability, hemocompatibility, suitable mechanical properties, reasonable price, and ease of use. Recent research shows that some natural polymers such as oxidized cellulose, chitosan, starch, collagen and alginate have blood clotting properties. This study has investigated the binding performance, polymer source of these materials and products available in the market.

Materials and Methods
In this research, the role of bleeding coagulation by natural polymers was investigated in 55 authentic English and Farsi articles. International and Persian publications such as Elsevier, Springer, Wiley Online Library, ScienceDirect and SID were used. Keywords and functional words such as blood clots, sodium alginate, chitosan, hemostatic, oxidized cellulose, collagen and starch were used for searching.

Results
The first step in wound healing is ligation. Subsequent steps that contribute to tissue regeneration include inflammation, proliferation, and remodeling. These materials are divided into synthetic and natural in the world market and research works. Natural coagulant polymers include oxidized cellulose, chitosan, collagen, starch, and alginate. Next, description of natural polymers, brief introduction of synthetic polymers, physical structure of binders and commercial samples have been discussed.

Conclusions 
The use of natural polymers as hemostatic agents shows the high potential of these substances in improving therapeutic processes and reducing the side effects caused by synthetic substances, which can lead to the development of new and effective strategies in the management of acute bleeding.

Key words: Blood Clot, Wounds, Polymers, Coagulant, Bleeding, Chitosan, Starch, Alginate





Received:  27 May 2024
Accepted: 21 Aug  2024



Correspondence: Shahrousvand M., PhD of polymer engineering, Assistant professor of caspian faculty of Engineering, College of Engineering, University of Tehran.
P.O.Box: 119-43481, Rezvanshahr, Iran. Tel: (+9813) 44608604; Fax: (+9813) 44608600
E-mail: m.shahrousvand@ut.ac.ir
 
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Eslahi kalurazi A, Shahrousvand M, Davachi S, Mohammadi-Rovshandeh J, Mobayen M. Hemostatic materials based on natural polymers. Sci J Iran Blood Transfus Organ 2024; 21 (3) :254-267
URL: http://bloodjournal.ir/article-1-1536-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 3 (Autumn 2024) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4660