Abstract
Background and Objectives
Bleeding agents play a vital role in preventing complications from uncontrolled bleeding, such as death and organ damage. In addition to maximum coagulation speed and minimal blood loss, these compounds should have features such as biocompatibility, degradability, hemocompatibility, suitable mechanical properties, reasonable price, and ease of use. Recent research shows that some natural polymers such as oxidized cellulose, chitosan, starch, collagen and alginate have blood clotting properties. This study has investigated the binding performance, polymer source of these materials and products available in the market.
Materials and Methods
In this research, the role of bleeding coagulation by natural polymers was investigated in 55 authentic English and Farsi articles. International and Persian publications such as Elsevier, Springer, Wiley Online Library, ScienceDirect and SID were used. Keywords and functional words such as blood clots, sodium alginate, chitosan, hemostatic, oxidized cellulose, collagen and starch were used for searching.
Results
The first step in wound healing is ligation. Subsequent steps that contribute to tissue regeneration include inflammation, proliferation, and remodeling. These materials are divided into synthetic and natural in the world market and research works. Natural coagulant polymers include oxidized cellulose, chitosan, collagen, starch, and alginate. Next, description of natural polymers, brief introduction of synthetic polymers, physical structure of binders and commercial samples have been discussed.
Conclusions
The use of natural polymers as hemostatic agents shows the high potential of these substances in improving therapeutic processes and reducing the side effects caused by synthetic substances, which can lead to the development of new and effective strategies in the management of acute bleeding.
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