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Sci J Iran Blood Transfus Organ 2021, 18(2): 142-147 Back to browse issues page
A Case Report of Acute T Cell Lymphoblastic Leukemia with Complex Chromosomal Abnormalities in a Child with Ataxia Telangiectasia
M. Safavi , A. Safaei, Gh.R. Fathpour
Keywords: Ataxia Telangiectasia, Cytogenetic Aberrations, Leukemia
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Type of Study: case report | Subject: Hematology and Oncology
Published: 2021/07/1
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   References:
  1. Karrman K, Johansson B. Pediatric T-cell acute lymphoblastic leukemia. Genes, Chromosomes and Cancer. 2017; 56(2): 89-116.
  2. Sharma A, Buxi G, Yadav R, Kohli A. Ataxia telangiectasia: A report of two cousins and review of literature. Indian J Med Paediatr Oncol 2011; 32(4): 217-22.
  3. Keklik M, Koker MY, Sivgin S, Camlica D, Pala C, Cetin M, et al. Detection of Acute Lymphoblastic Leukemia Involvement in Pleural Fluid in an Adult Patient with Ataxia Telangiectasia by Flow Cytometry Method. Indian J Hematol Blood Transfus 2014; 30(1): 73-6.
  4. Huang KY, Shyur SD, Wang CY, Shen EY, Liang DC. Ataxia telangiectasia: report of two cases. J Microbiol Immunol Infect 2001; 34(1): 71-5.
  5. Alyasin S, Esmaeilzadeh H, Ebrahimi N, Nabavizadeh SH, Nemati H. Clinical presentation of ataxia-telangiectasia. Arch Iran Med 2019; 22(12): 682-6.
  6. Viniou N, Terpos E, Rombos J, Vaiopoulos G, Nodaros K, Stamatopoulos K, et al. Acute myeloid leukemia in a patient with ataxia-telangiectasia: a case report and review of the literature. Leukemia 2001; 15(10): 1668-70.
  7. Meier M, Den Boer ML, Hall AG, Irving JA, Passier M, Minto L, et al. Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia. Leukemia. 2005; 19(11): 1887-95.
  8. Taylor AM, Metcalfe JA, Thick J, Mak YF. Leukemia and lymphoma in ataxia telangiectasia. Blood. 1996; 87(2): 423-38.
  9. Cao J, Tan RY, Li ST, Courtney E, Goh RC, Fan BE, et al. Identifying ataxia-telangiectasia in cancer patients: Novel insights from an interesting case and review of literature. Clin Case Rep 2021; 9(2): 995-1009.
  10. Janic D, Dokmanovic L, Jovanovic N, Lazic J. T-cell acute lymphoblastic leukemia in a child with ataxia-telangiectasia: case report. J Pediatr Hematol Oncol 2007; 29(10): 713-5.
  11. Huret JL. t(8;17)(q24;q22) ???BCL3/MYC. Atlas Genet Cytogenet Oncol Haematol 2012; 16(3): 236-7.
 
 
 
 
 
 
 
 
 
 

 
 


 
 
 
Sci J Iran Blood Transfus Organ 2021; 18 (2): 142-147
 
 
Case  report
 
 
 

A Case Report of Acute T Cell Lymphoblastic Leukemia
with Complex Chromosomal Abnormalities in a Child
with Ataxia Telangiectasia
 
Safavi M.1, Safaei A.2, Fathpour Gh.R.3
 
1Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Pathology Department, Medical Faculty, Shiraz University of Medical Sciences, Shiraz, Iran
3Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
 
 
 
Abstract
Background and Objectives
Ataxia telangiectasia is a disease with chromosomal instability that causes susceptibility to malignancy.
 
Case
The patient was a 7-year-old boy living in Shiraz who had ataxia telangiectasia and was hospitalized due to fever and lymphadenopathy. Bone marrow aspiration showed a 60% blast population that was consistent with acute T cell lymphoblastic leukemia, immunophenotypically. In cytogenetic examination of bone marrow aspiration, complex chromosomal abnormalities as 42,XY,-5,del(6)(q22),der(8)t(8;17)(q24;q12~q22),t(9;16) (q12;q24),dic(12;14)(p11;q24),+13,-14,-22 were observed. Despite chemotherapy, the patient expired after two relapses of leukemia.
 
Conclusions 
T cell acute lymphoblastic leukemia due to ataxia telangiectasia  can be associated with complex karyotype abnormalities leading to leukemia relapse and adverse prognosis.

Key words: Ataxia Telangiectasia, Cytogenetic Aberrations, Leukemia
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
Received: 13 Feb  2021
Accepted:  1 May 2021
 
 
 

Correspondence: Safavi M., MD, Pathlogist and Fellow of Molecular Pathology and Cytogenetics. Assistant Professor of Pathology Department, Children's Medical Center, Tehran University of Medical Sciences.
Postal code: 1419733151, Tehran, Iran. Tel: (+9821) 61472404; Fax: (+9821) 66948780
E-mail: moein.safavi@gmail.com
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Safavi M, Safaei A, Fathpour G. A Case Report of Acute T Cell Lymphoblastic Leukemia with Complex Chromosomal Abnormalities in a Child with Ataxia Telangiectasia. Sci J Iran Blood Transfus Organ. 2021; 18 (2) :142-147
URL: http://bloodjournal.ir/article-1-1395-en.html


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Volume 18, Issue 2 (Summer 2021) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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