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:: Volume 14, Issue 1 (Spring 2017) ::
Sci J Iran Blood Transfus Organ 2017, 14(1): 65-76 Back to browse issues page
In silico studies revealed a crucial role for miR-146a on progression of Helicobacter pylori induced gastric cancer 
B. Adami , K. Ghaedi , A. Talebi
Keywords: Key words: Stomach neoplasms, Helicobacter Pylori, microRNA
Full-Text [PDF 641 kb]   (3809 Downloads)     |   Abstract (HTML)  (5889 Views)
Type of Study: Review Article | Subject: Microbiology
Published: 2017/03/14
Full-Text:   (6855 Views)
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Review Article
 
 
 
 
Sci J Iran Blood Transfus Organ 2017; 14(1): 65-76
 
 

 

In silico studies revealed a crucial role
for miR-146a on progression of Helicobacter pylori
induced gastric cancer
 
Adami B.1, Ghaedi K.2,3, Talebi A.4
 
 
1Faculty of Biological Science, Islamic Azad University, Falavarjan Branch, Isfahan, Iran
2School of Science, University of Isfahan, Isfahan, Iran
3Department of Cellular Biotechnology at Cell Science Research Center, ACECR, Royan Institute for Biotechnology, Isfahan, Iran
4School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
 
Abstract
Background and Objectives
Stomach cancer is currently ranked as the fourth most common cancer and the second regarding to the mortality rate. Environmental and genetic factors both play crucial role in the onset of inflammation in the stomach and progression of the cancer. In a majority of gastric cancer cases, Helicobacter Pylori infection is a responsible factor. Nowadays, the micro RNAs are pinpointed as the powerful molecules in the field of disease genetics. In the present study by implementing several bioinformatics database, we have undertaken a research on the association of miR-146a with the expression of the genes involved in cell signaling pathways in gastric cancer development.
 
Materials and Methods
This type of study was theoretical bioinformatics. The first step to candidate the most important miRNAs is to collect data from the previous studies; then, miRWalk 2.0 and miRTarBase databases were chosen for primary studies. The final review was made at David database in order to achieve pathways involved in gastric cancer.
 
Results
Based on the results from this study, miR-146a was predicated as a key factor in preventing the cancer progression by affecting an increase on metastasis and tissue attack and preventing apoptotic pathways.
 
Conclusions
Data revealed that the expression of miR-146a increased the progress of gastric cancer. Thus, the analysis of the miR-146a expression could be accounted as a valuable marker for prognosis of gastric cancer.
 
Key words: Stomach Neoplasms, MicroRNAs, Helicobacter
 
 
 
Received: 17 Oct 2016
Accepted: 1 Jan  2017
 
 

Correspondence: Ghaedi K, PhD of Molecular Biology. Associate Professor of School of Science, University of Isfahan & Department of Cellular Biotechnology at Cell Science Research Center, ACECR, Royan Institute for Biotechnology.
Postal code: 81746-73441, Isfahan, Iran. Tel: (+9831) 37932479; Fax: (+9831) 37932479
E-mail:
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kamranghaedi@yahoo.com
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Adami B, Ghaedi K, Talebi A. In silico studies revealed a crucial role for miR-146a on progression of Helicobacter pylori induced gastric cancer . Sci J Iran Blood Transfus Organ 2017; 14 (1) :65-76
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فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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