Volume 14, Issue 2 (Summer 2017)                   Sci J Iran Blood Transfus Organ 2017, 14(2): 118-125 | Back to browse issues page

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Moradveisi B, Safari H, Roshani D, Khalafi B, Raghizadeh Sarvestani R. Frequency of Chromosome Disorders in the Childrenwith Acute Leukemia Referred to the OncSanandaj Besat Hospitalology Ward of . Sci J Iran Blood Transfus Organ 2017; 14 (2) :118-125
URL: http://bloodjournal.ir/article-1-1055-en.html
Frequency of Chromosome Disorders in the Childrenwith Acute Leukemia Referred to the OncSanandaj Besat Hospitalology Ward of
B. Moradveisi , H. Safari , D. Roshani , B. Khalafi , R. Raghizadeh Sarvestani *
Keywords: Key words: Leukemia, Chromosome Disorders, Children
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Original  Article
 

 
 
 
Sci J Iran Blood Transfus Organ 2017; 14(2): 118-125
Frequency of Chromosome Disorders in the Children
with Acute Leukemia Referred to the Oncology Ward of Sanandaj Besat Hospital
 
Moradveisi B.1, Safari H.2, Roshani D.1, Khalafi B.2, Taghizadeh Sarvestani R.3
 
 
1Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
2Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
3Faculty of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran 
 
 
Abstract
Background and Objectives
Blood Malignancies are the most frequent cancers in children including about 45% of diagnosed cancers in children. Chromosome disorders are found in most of patients with acute lymphoblastic leukemia. These disorders present valuable information for prognostic determinants.
 
Materials and Methods
This descriptive study includes all the children with acute leukemia having referred to the oncology ward of Besat Hospital of Sanandaj from 1385 to the end of the first half of 1394. Peripheral blood smear and bone marrow aspirations were taken from the children; RT-PCR method was used for determination of chromosome karyotypes so as to detect chromosome disorders. The data were analyzed by SPSS 11.5 & c2 test.
Results
Among 75 cases, 12 chromosome genotypes were observed. Normal chromosome genotype has the highest frequency with 41 cases (54.7%). t(12-21) chromosome disorder observed in 15 cases (20%) was the most frequent disorder. t(15-17) chromosome disorder observed in 5 cases (6.5%) was the next most frequent disorder. The only chromosome disorder observed in T lymphocyte leukemia was 47xy + 21 with the frequency of 1 case.
 
Conclusions
Based on the research findings, 54.7% of the children have no chromosome disorders. Different results are reported in different researches. Due to the importance of finding the types of chromosome translocation for prognostic determinants in children with leukemia, more research is required.
 
Key words: Leukemia, Chromosome Disorders, Children
 
 
 
 
 
 
Received: 20  Jul  2016
Accepted: 21 Jan 2017
 
 
 

Correspondence: Taghizadeh Sarvestani R., MD. Assistant Professor of Faculty of Medicine, Shahroud University of Medical Sciences.
Postal Code: 6617967617, Shahroud, Iran. Tel: (+9823) 32385890; Fax: (+9823) 32385890
E-mail: rt_sarvestani@yahoo.com
Type of Study: Research | Subject: Hematology and Oncology
Published: 2017/06/18
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