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Abstract
Background and Objectives
Blood Malignancies are the most frequent cancers in children including about 45% of diagnosed cancers in children. Chromosome disorders are found in most of patients with acute lymphoblastic leukemia. These disorders present valuable information for prognostic determinants.
Materials and Methods
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This descriptive study includes all the children with acute leukemia having referred to the oncology ward of Besat Hospital of Sanandaj from 1385 to the end of the first half of 1394. Peripheral blood smear and bone marrow aspirations were taken from the children; RT-PCR method was used for determination of chromosome karyotypes so as to detect chromosome disorders. The data were analyzed by SPSS 11.5 & c2 test. |
Results
Among 75 cases, 12 chromosome genotypes were observed. Normal chromosome genotype has the highest frequency with 41 cases (54.7%). t(12-21) chromosome disorder observed in 15 cases (20%) was the most frequent disorder. t(15-17) chromosome disorder observed in 5 cases (6.5%) was the next most frequent disorder. The only chromosome disorder observed in T lymphocyte leukemia was 47xy + 21 with the frequency of 1 case.
Conclusions
Based on the research findings, 54.7% of the children have no chromosome disorders. Different results are reported in different researches. Due to the importance of finding the types of chromosome translocation for prognostic determinants in children with leukemia, more research is required.
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