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:: Volume 11, Issue 1 (Spring 2014 2015) ::
Sci J Iran Blood Transfus Organ 2015, 11(1): 48-55 Back to browse issues page
Evaluation of the association between FGBrs1800790 ‎‏ ‏and plasma fibrinogen levels
A. Mashayekhi, Sh. Shahbazi
Abstract:   (7734 Views)

  Abstract

  Background and Objectives

 Fibrinogen, coagulation factor 1, is a soluble plasma glycoprotein which converts thrombin to fibrin fibers in the coagulation cascade. Various polymorphisms located on beta chain gene, FGB, have been studied. The promoter – G455A (rs1800790) polymorphism had been shown to be significantly associated with fibrinogen plasma levels. In this study, the frequency of rs1800790 ‎ polymorphism has been assessed and the correlation was evaluated between this variant and fibrinogen plasma levels.

 

  Materials and Methods

 Whole blood samples were collected for DNA isolation. To perform ‎ rs1800790 ‎ genotyping, the region encompassing the HaeIII restriction site was amplified using specific primers. The plasma levels of fibrinogen were measured and the obtained data were analyzed by SPSS software.

 

  Results

  The levels of plasma fibrinogen has shown a significant correlation with FGBrs1800790 ‎ genotype (p-value = 0.021 ‎ ‏ ‏ CI = 0 ‎ .347 ‎ ‏- ‎‎ 3.253). Minor allele frequency was estimated to be 0.28 which was consistent with the predicted value.

 

  Conclusions

  The significant correlation between fibrinogen and FGBrs1800790 ‎ genotype emphasizes the importance of this variant in the modulation of fibrinogen plasma concentrations. Since FGBrs1800790 ‎ contributes to the gene expression and environmental risk factors, it is important to be noticed in the cardiovascular disease.

 

   

Keywords: Key words: Fibrinogen, Genetic Polymorphism, RFLP
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Type of Study: Research | Subject: Blood transfusion medicine
Published: 2014/03/16
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Mashayekhi A, Shahbazi S. Evaluation of the association between FGBrs1800790 ‎‏ ‏and plasma fibrinogen levels. Sci J Iran Blood Transfus Organ. 2015; 11 (1) :48-55
URL: http://bloodjournal.ir/article-1-855-en.html


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Volume 11, Issue 1 (Spring 2014 2015) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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