Scientific Journal of

  Abstract

 Background and Objectives

 Natural autoantibodies (N-Auto-Abs) are a class of antibodies that are formed without any previous provocation against their own. Currently an important role has been proposed for these antibodies in immune homeostasis as we can study them as biological markers to predict the onset of the disease. For the first time, we studied the prevalence of N-Auto-Abs against RBC antigens as well as the prevalence of cold antibodies in blood donors.

 Materials and Methods

 Three hundred healthy individuals who donated at Tehran Blood Transfusion Center were selected randomly their blood samples were collected including 289 (96.3%) males and 11 (3.7%) female. Their age range is within 17-64 years. EDTA plasma was evaluated for the study of N-Auto-Abs that reacted at 4C.

 Results

 28 individuals (9.34%) showed positive reaction with their own cell suspension. In addition, 55 individuals (18.34%) were positive for cold antibodies.

 Conclusions

 Twenty eight individuals (9.34%) showed positive reaction with their own cell suspension. In addition, 55 individuals (18.34%) were positive for cold antibodies.