Abstract

 Background and Objectives

  In chronic blood transfusion, antibody production against minor blood groups may occur and sometimes it could be clinically significant lowering RBC life span. This is a case report of allimmunization against M-antigen in a 15-month baby with neuroblastoama. This antibody was IgG type and produced some trouble for blood transfusion in this patient.

  Case

  A 15-month baby with neuroblastoma was referred to our center. Neuroblastoma is one of the most solid tomors in children and chemotherapy must be done for the patient suffering from it. During the treatment course the patients may need blood transfusion because of the suppressive effect of BM by chemotheraputic drugs. This patient had history of blood transfusion one year ago, but this time he faced a severe blood transfusion reaction and was then referred to our center to be considered for alloimmunization and receive compatible blood.

  Conclusions

  Our tests (Ab screening, pannel case) showed this patient has anti-M antibody IgG type. This finding was very important because antibody production against minor or rare blood groups produced significant problems. M-antibodies are mostly of IgM type and not clinicaly important but in some cases as in our patients it brought about adverse reactions. After preparing and administering compatible blood, the patient manifested no severe reactions or any other problems. .

 Key words: Alloimmunization, Neuroblastoma, Anti-M