Scientific Journal of

  Abstract

 Background and Objectives

  Some platelet membrane glycoprotein gene polymorphisms have been reported as potential factors related to cardiovascular complications . Recently, the -5T/C polymorphism located at the initiation element (Kozak sequence) of the platelet glycoprotein Ibα (GPIbα) translation was suggested to increase the platelet surface levels of GPIb-IX-V receptor however, its function in the occurrence of arterial thrombotic disease is unknown . In this study, we evaluated the role of the GP Ibα -5T/C polymorphism in premature myocardial infraction among Iranian patients .

 Materials and Methods

  Two hundred subjects who underwent coronary angiography were studied on the basis of the study protocol through 2010. Patients (n=100) selected by WHO criteria and matched on age parameter with controls (n=100 Men <50 years old and Women < 55 years old). The genotype distribution of GP Ibα -5T/C polymorphism was evaluated by PCR-RLFP technique .

 Results

 There were no significant differences in age, hypertension, and diabetes between the patients and controls. However, the sex, family history of CAD, smoking and hyperlipidemia had a significant difference between the two groups. The allele frequencies of C and T were calculated to be 0.13 and 0.87, respectively. In addition, the CC genotype showed to be a potential factor for the occurrence of myocardial infarction ( p=0.56, OR = 3.06 , CI(95%) = 0.31-29.94).

 Conclusions

  Although no significant association was observed between the - 5C/T polymorphism and premature myocardial infraction, we considered that the C allele may be an effective factor for premature myocardial infraction .