[Home ] [Archive]   [ فارسی ]  
:: Main :: About us :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 4, Issue 3 (Autumn 2007) ::
Sci J Iran Blood Transfus Organ 2007, 4(3): 199-203 Back to browse issues page
HLA DRB1 polymorphism in the Iranian population
F. Yari, N. Bagheri, M. Zaman Vaziri, M. Sobhani, F. Sabaghi, A. Talebian
Abstract:   (17987 Views)



 Background and Objectives

 Major Histocompatibility Complex (MHC) is the most polymorphic system in the genome of different species. In human beings, these genes named HLA are located on the chromosome 6. HLA class I and II undertake genetic control of the immune system. Identification of HLA alleles is useful in transplantation, disease, and anthropological studies. Among different antigens of HLA, DR (DRB1) antigens are the most variable. In this research, due to the importance of DRB1 antigens in bone marrow transplantation, these antigens were studied in normal population. This study was performed on different Iranian races and did not suffice to a specific group.


 Materials and Methods

 DNA was extracted from the whole blood sample of 466 normal individuals after randomized sampling. Some HLA-DRB locus segments were amplified using 23 primer pairs by using PCR-SSP method. Finaly, PCR products were evaluated by electrophoresis in 2% agarose gel.



 The most prevalent alleles in DRB1 locus in normal poulation of Iran were DRB1*11, DRB1*13, DRB1*15, and DRB1*04 (20%, 11.4%, 11.4%, 10%, respectively). Whereas DRB1* 09 was the least frequent allele.



 This research showed genetic diversity of HLA DRB1 in the mixed Iranian population. The data suggest that the Iranian population share certain HLA class II genetic components with the populations residing in Russia and Eastern and Southern European countries.


 Key words : HLA-DRB1, PCR, Iran


Keywords: HLA-DRB1, PCR, Iran
Full-Text [PDF 203 kb]   (2875 Downloads)    
Type of Study: Research | Subject: Genetis
Published: 2014/08/17
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yari F, Bagheri N, Zaman Vaziri M, Sobhani M, Sabaghi F, Talebian A. HLA DRB1 polymorphism in the Iranian population. Sci J Iran Blood Transfus Organ 2007; 4 (3) :199-203
URL: http://bloodjournal.ir/article-1-174-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 3 (Autumn 2007) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
Persian site map - English site map - Created in 0.11 seconds with 31 queries by YEKTAWEB 4549