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Eslami R, Heidary D, Mehdipour A, Heidari S. The Effects of Acute Exercise and Exercise Training onPlasma Fibrinogen Levels in Healthy Individuals:A Meta-Analysis. Sci J Iran Blood Transfus Organ 2021; 18 (2) :127-141
URL: http://bloodjournal.ir/article-1-1379-en.html

Abstract
Background and Objectives
The aim of this meta-analytical review was to compare the effect of different exercise training on plasma fibrinogen levels as well as to evaluate the acute and chronic response of fibrinogen to exercise.
 
Materials and Methods
In order to study the effects of exercise training on fibrinogen, a search was conducted in the databases of PubMed, Science Direct, Scopus, and Google Scholar. The search used identified keywords and reviewed articles published between 2010 and 2020. After the initial screening, full-text review and critical evaluation of the studies, the articles that met the inclusion criteria were analyzed. Finally, 22 studies including 33 trials with meta-analysis inclusion criteria were analyzed.
 
Results
The results of meta-analysis show that the acute response of fibrinogen to exercises is incremental, but the increase is not significant. On the other hand, the chronic response of fibrinogen to exercises is significantly reductive, which is related to aerobic exercise and high-intensity interval training and the response to anaerobic exercise is negligible.
 
Conclusions 
In general, it can be said that exercise can be effective in modifying vascular fibrinogen levels. In various studies, in the acute response to exercise, there have been no change or increase in plasma fibrinogen levels but in the chronic response to exercise, a decrease in plasma fibrinogen levels has been reported. However, there is still a need for high quality studies with a sufficient sample size in this field.