Volume 19, Issue 3 (Autumn 2022)
Sci J Iran Blood Transfus Organ 2022, 19(3): 183-190 |
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Arabpoor N, Karimi G, Arabkhazaeli A, Haji Abdolbaghi M, Shahabi M. SLCO2B1 gene polymorphism and anti-retroviral therapy side effects in HIV-1 infected patients. Sci J Iran Blood Transfus Organ 2022; 19 (3) :183-190
URL: http://bloodjournal.ir/article-1-1374-en.html
URL: http://bloodjournal.ir/article-1-1374-en.html
Abstract: (956 Views)
Abstract
Background and Objectives
HIV virus and its subsequent disease is one of the most important challenges of the world health system. Although antiretroviral therapy (ART) is a breakthrough in patients’ life quality, it has complications like side effects. The side effect causes are diverse. One of the factors considered about side effects is genes polymorphism. This study investigates the relationship between rs2712816 and rs949096 polymorphisms on SLCO2B1 gene which is one of the most important antiretroviral drugs transporters.
Materials and Methods
In this Cross-sectional study, the two variants, rs2712816 and rs949069 were genotyped on 161 samples of HIV-1 infected patients. Consequently, the records of patients in Imam Khomeini Behavioral Diseases Center were reviewed and necessary data were collected. Statistical analysis was done by chi-square, exact Fisher test, and Mann Whitney U test using SPSS 26.0.
Results
The results show that there is a significant relationship between AA genotype in rs949069 polymorphism and dizziness and urticaria in patients (p< 0.05). The rs2712816 polymorphism and side effects did not show any significant relationship.
Conclusions
There are different factors involved in antiretroviral therapy side effects. According to the results of this study, the rs949069 is one of the factors.
Background and Objectives
HIV virus and its subsequent disease is one of the most important challenges of the world health system. Although antiretroviral therapy (ART) is a breakthrough in patients’ life quality, it has complications like side effects. The side effect causes are diverse. One of the factors considered about side effects is genes polymorphism. This study investigates the relationship between rs2712816 and rs949096 polymorphisms on SLCO2B1 gene which is one of the most important antiretroviral drugs transporters.
Materials and Methods
In this Cross-sectional study, the two variants, rs2712816 and rs949069 were genotyped on 161 samples of HIV-1 infected patients. Consequently, the records of patients in Imam Khomeini Behavioral Diseases Center were reviewed and necessary data were collected. Statistical analysis was done by chi-square, exact Fisher test, and Mann Whitney U test using SPSS 26.0.
Results
The results show that there is a significant relationship between AA genotype in rs949069 polymorphism and dizziness and urticaria in patients (p< 0.05). The rs2712816 polymorphism and side effects did not show any significant relationship.
Conclusions
There are different factors involved in antiretroviral therapy side effects. According to the results of this study, the rs949069 is one of the factors.
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