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:: Volume 2, Issue 6 (Winter 2006) ::
Sci J Iran Blood Transfus Organ 2006, 2(6): 253-258 Back to browse issues page
Evaluation of Serumic beta-2 microglobulin in HBsAg+ HBV DNA PCR+ and HBsAg+ HBV DNA PCR- subjects: as HBV replication marker
Shaiegan M. , Tarabadi F.A. , Amini Kafi-abad S. , Samiei Sh. , Babaeie Gh. , Talebian A.
Abstract:   (16334 Views)

  Abstract

  

 Background and Objectives

  Beta-2 microglobulin ( β 2MG) is the light chain of Histocompatibility–Class I human antigen and its normal range is <3mg/ml. β 2MG level in sera of hepatitis B patients increases. In Hepatitis infection the presentation of the viral antigen on the hepatocyte in the presence of Class I HLA antigen plays a major role in the elimination of the virus.

 

  Materials and Methods

  In this descriptive study, s β 2MG, HBsAg (by ELISA), and HBV DNA (by PCR) were evaluated in sera of 49 patients with hepatitis B and 35 subjects in control group .

 

 Results

  Our results showed HbsAg was positive in all patients. 29 of patients were HBV-DNA-PCR positive and 20 HBV-DNA-PCR negative. β 2MG in all subjects in control group was in normal range and in 34.7% of patients above normal limit. β 2MG in HBV-DNA-PCR positive patients was higher than HBV DNA PCR negative patients. Such differences were significant (p < 0.05) .

 

 Conclusions

  It seems S β 2MG is a good marker for HBV replication and its absence may exclude HBV replication. The role of β 2MG in monitoring response to therapy needs to be further evaluated.

  

  

 Key words: Hepatitis B virus, HBsAg , β 2MG (beta - 2 microglobulin), PCR , ELISA

Keywords: Hepatitis B virus, HBsAg, β 2MG (beta - 2 microglobulin), PCR, ELISA
Full-Text [PDF 233 kb]   (2517 Downloads)    
Type of Study: Research | Subject: General
Published: 2014/08/19
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Shaiegan M., Tarabadi F.A., Amini Kafi-abad S., Samiei Sh., Babaeie Gh., Talebian A.. Evaluation of Serumic beta-2 microglobulin in HBsAg+ HBV DNA PCR+ and HBsAg+ HBV DNA PCR- subjects: as HBV replication marker. Sci J Iran Blood Transfus Organ 2006; 2 (6) :253-258
URL: http://bloodjournal.ir/article-1-94-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2, Issue 6 (Winter 2006) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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