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:: Volume 8, Issue 3 (Autumn 2011) ::
Sci J Iran Blood Transfus Organ 2011, 8(3): 158-164 Back to browse issues page
Association of C609T and C465T polymorphisms of NQO1 gene with AML
A. Safaei , F. Zaker , H. Sharafi , M. Hashemi , P. Yaghmaei , M. Abdolahzadeh
Abstract:   (15881 Views)

  Abstract

 Background and Objectives

 Many studies have demonstrated that polymorphisms of NQO1 including C465T and C609T are associated with increased risk of acute myeloid leukemia(AML). Our aims are to assess incidence of these polymorphisms in Tehran patients and study the influence of low activity of NQO1 in AML.

 

 Materials and Methods

 In this case-control study, we used PCR and RFLP analyses to study the prevalence of C609T NQO1in 140 patients, and C465T NQO1 in 124 patients there was also a control group of 80 being age-sex matched. We calculated odd ratio with SPSS 16 to examine if these polymorphisms are associated with AML.

  

 Results

 No significant association between the two common polymorphisms of NQO1 and risk of AML was observed. C609T odd ratio for TT genotype versus CC was obtained to be 0.91 (CI 95% = 0.51-1.63) and for CT versus CC it was 1.06 (CI 95% = 0.57-1.95). C465T odd ratio for TT genotype versus CC was calculated to be 0.22 (CI 95% = 0.009-5.56) and for CT versus CC it came out to be 3.01(CI 95% = 0.63-14.32).

  

 Conclusions

 Our findings suggest that the NQO1 C609T and C465T gene variants do not have a major influence on the susceptibility to adult AML.

Keywords: Plymorphism, Genetic, Acute Myeloid Leukemia, NQO1 Protein, human
Full-Text [PDF 248 kb]   (2893 Downloads)    
Type of Study: Research | Subject: Hematology
Published: 2014/07/22
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Safaei A, Zaker F, Sharafi H, Hashemi M, Yaghmaei P, Abdolahzadeh M. Association of C609T and C465T polymorphisms of NQO1 gene with AML . Sci J Iran Blood Transfus Organ 2011; 8 (3) :158-164
URL: http://bloodjournal.ir/article-1-513-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 8, Issue 3 (Autumn 2011) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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