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URL: http://bloodjournal.ir/article-1-27-en.html
, A. Mohammadzadeh Kazorgah , M. Ghaffari Novin , S. Arefi , M.H. Modarresi , F. Shokri , P. Dokuhaki , M.R. Sadeghi , M.M. Akhoondi , A. Gharehbaghian , M. Jeddi Tehrani
Abstract
Background and Objectives
During pregnancy, irregular blood group antibodies originating either from earlier pregnancies or from blood transfusions may severely affect child health. In this report, a case of maternal alloimmunization to Kell antigen is described.
Case
The mother had a history of partial mole and four repeated intrauterine fetal death due to hydrops fetalis.
Conclusions
Screening of irregular blood group antibodies revealed that she has anti-Kell with the titer of 1:4096. Also in genetic analysis, a C677T homozygous mutation of MTHFR gene was found, which could potentially enhance destructive effects of anti-Kell antibody. The described case emphasizes the importance of being informed about the presence of irregular blood group antibodies during pregnancy which may cause recurrent hydrops.
Key words: Pregnancy, Hydrops, Immunization, Kell antigen
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