Volume 23, Issue 3 (Autumn 2026)
bloodj 2026, 23(3): 203-211 |
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Ethics code: IR.IAU.KHUISF.REC.1398.111
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Karimi M, Javadzadeh Shahshahani H, Mortazavizadeh M. Assessment of Platelet Transfusion Appropriateness and Adherence to Clinical Guidelines in Two Educational Hospitals
in Yazd, Iran. , bloodj. 2026; 23 (3) :203-211
URL: http://bloodjournal.ir/article-1-1655-en.html
URL: http://bloodjournal.ir/article-1-1655-en.html
Abstract: (25 Views)
A B S T R A C T
Background and Objectives
Platelet transfusion is an essential therapeutic intervention in the management of patients with thrombocytopenia. However, inappropriate platelet transfusion may increase healthcare costs, cause transfusion-related complications, and contribute to the depletion of blood component resources. This study aimed to assess the appropriateness of platelet transfusions according to clinical guidelines in two teaching hospitals in Yazd, Iran.
Materials and Methods
This descriptive-analytical cross-sectional study included 200 patients who received platelet transfusions in two teaching hospitals in Yazd, Iran. Patient data, including age, sex, diagnosis, pre-transfusion platelet count, number of platelet units transfused, and indication for platelet transfusion, were extracted from medical records. The appropriateness of platelet transfusions was assessed according to international guidelines. Data were analyzed using SPSS version 22, with the chi-square test and non-parametric tests.
Results
Of the 200 patients included in the study, 103 (51.5%) were male, and the median age was 56 years (interquartile range [IQR], 37.75 to 71). The majority of platelet transfusions were administered to patients with hematological diseases and malignancies. Overall, platelet transfusion was appropriate according to clinical guidelines in 160 patients (80%) and inappropriate in 40 patients (20%). The median pre-transfusion platelet count was 14×10⁹/L (IQR, 8 to 23.5). All platelet transfusions administered to patients with platelet counts >100 × 10⁹/L were considered inappropriate. The proportion of appropriate transfusion was higher among patients with hematological disease and malignancies than among gynecological and surgical patients (91% vs 40%, p< 0.001).
Conclusions
Although most platelet transfusions were consistent with clinical guidelines, a considerable proportion were inappropriate, particularly among patients with higher platelet counts and in the surgical and gynecology wards. Educational programs, continuous monitoring of transfusion practices, and the use of clinical decision-support tools may help reduce unnecessary platelet transfusions and optimize the use of this blood component.
Background and Objectives
Platelet transfusion is an essential therapeutic intervention in the management of patients with thrombocytopenia. However, inappropriate platelet transfusion may increase healthcare costs, cause transfusion-related complications, and contribute to the depletion of blood component resources. This study aimed to assess the appropriateness of platelet transfusions according to clinical guidelines in two teaching hospitals in Yazd, Iran.
Materials and Methods
This descriptive-analytical cross-sectional study included 200 patients who received platelet transfusions in two teaching hospitals in Yazd, Iran. Patient data, including age, sex, diagnosis, pre-transfusion platelet count, number of platelet units transfused, and indication for platelet transfusion, were extracted from medical records. The appropriateness of platelet transfusions was assessed according to international guidelines. Data were analyzed using SPSS version 22, with the chi-square test and non-parametric tests.
Results
Of the 200 patients included in the study, 103 (51.5%) were male, and the median age was 56 years (interquartile range [IQR], 37.75 to 71). The majority of platelet transfusions were administered to patients with hematological diseases and malignancies. Overall, platelet transfusion was appropriate according to clinical guidelines in 160 patients (80%) and inappropriate in 40 patients (20%). The median pre-transfusion platelet count was 14×10⁹/L (IQR, 8 to 23.5). All platelet transfusions administered to patients with platelet counts >100 × 10⁹/L were considered inappropriate. The proportion of appropriate transfusion was higher among patients with hematological disease and malignancies than among gynecological and surgical patients (91% vs 40%, p< 0.001).
Conclusions
Although most platelet transfusions were consistent with clinical guidelines, a considerable proportion were inappropriate, particularly among patients with higher platelet counts and in the surgical and gynecology wards. Educational programs, continuous monitoring of transfusion practices, and the use of clinical decision-support tools may help reduce unnecessary platelet transfusions and optimize the use of this blood component.
Type of Study: Research |
Subject:
Blood transfusion medicine
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