Volume 23, Issue 2 (Summer 2026)
bloodj 2026, 23(2): 114-124 |
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Ethics code: IR.TMI.REC.1403.026
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Amini-Kafiabad S, Zarei D, Naderyan Feli S, Akbarzadeh M, Dehghan M, Zarnegar G et al . Effect of Pre-Donation Water Intake on Hemoglobin and Plasma Volume in Blood Donors: A Field Trial. bloodj 2026; 23 (2) :114-124
URL: http://bloodjournal.ir/article-1-1622-en.html
URL: http://bloodjournal.ir/article-1-1622-en.html
Sedigheh Amini-Kafiabad * 
, Davood Zarei , Shadi Naderyan Feli , Majid Akbarzadeh , Mandana Dehghan , Gholnoush Zarnegar , Fatemeh Moazen
, Davood Zarei , Shadi Naderyan Feli , Majid Akbarzadeh , Mandana Dehghan , Gholnoush Zarnegar , Fatemeh Moazen
Abstract: (444 Views)
Background and Objectives
Plasma serves as the only source for the production of plasma-derived medicinal products, making it a crucial priority to minimize plasma wastage. This study aimed to evaluate the effectiveness of a pre-donation water intake strategy in reducing plasma unit discard rates due to low-volume units.
Materials and Methods
In this field trial study, a total of 145 blood donors were allocated into three intervention groups, with intervals of 10 ± 2, 15 ± 2, and 20 ± 2 minutes between oral water intake and blood collection. Additionally, 49 donors were included in the control group and had no prior water intake. All blood donations were performed using double blood bags. Hemoglobin (Hb) levels were measured before and during the blood donation and compared between interventional groups. Plasma volumes were compared between the intervention and control groups. Data were analyzed using chi-square tests, independent t-tests, and paired t-tests as appropriate statistical methods.
Results
No significant difference in Hb distribution was observed among the four study groups. Following water intake, a reduction in Hb levels was observed in the majority of donors within the intervention groups, increasing from 60% at 10 ± 2 minutes to 72% at 20 ± 2 minutes. The mean differences in Hb levels before and after the intervention ranged from 0.11 to 0.28 g/dL across the intervention groups (p < 0.05). Whole blood collection volume ranged between 435 and 492 mL, while the mean recovered plasma volume in all groups exceeded 250 mL, accounting for more than 53% of total blood volume. However, the mean plasma volume did not differ significantly between the interventional groups and the control group.
Conclusions
Water intake alone did not increase plasma volume compared with the control group. To improve recovered plasma volume and minimize wastage, it is important to consider the donor hydration status and related factors, particularly for donors with high Hb levels. The use of double bags in this study ensured that the volume of all collected plasma units was within the acceptable range.
Plasma serves as the only source for the production of plasma-derived medicinal products, making it a crucial priority to minimize plasma wastage. This study aimed to evaluate the effectiveness of a pre-donation water intake strategy in reducing plasma unit discard rates due to low-volume units.
Materials and Methods
In this field trial study, a total of 145 blood donors were allocated into three intervention groups, with intervals of 10 ± 2, 15 ± 2, and 20 ± 2 minutes between oral water intake and blood collection. Additionally, 49 donors were included in the control group and had no prior water intake. All blood donations were performed using double blood bags. Hemoglobin (Hb) levels were measured before and during the blood donation and compared between interventional groups. Plasma volumes were compared between the intervention and control groups. Data were analyzed using chi-square tests, independent t-tests, and paired t-tests as appropriate statistical methods.
Results
No significant difference in Hb distribution was observed among the four study groups. Following water intake, a reduction in Hb levels was observed in the majority of donors within the intervention groups, increasing from 60% at 10 ± 2 minutes to 72% at 20 ± 2 minutes. The mean differences in Hb levels before and after the intervention ranged from 0.11 to 0.28 g/dL across the intervention groups (p < 0.05). Whole blood collection volume ranged between 435 and 492 mL, while the mean recovered plasma volume in all groups exceeded 250 mL, accounting for more than 53% of total blood volume. However, the mean plasma volume did not differ significantly between the interventional groups and the control group.
Conclusions
Water intake alone did not increase plasma volume compared with the control group. To improve recovered plasma volume and minimize wastage, it is important to consider the donor hydration status and related factors, particularly for donors with high Hb levels. The use of double bags in this study ensured that the volume of all collected plasma units was within the acceptable range.
Type of Study: Research |
Subject:
Blood donation
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