Ethics code: IR.AJUMS.MEDICINE.REC.1403.039
Akram Ahangarpour 
, Arash Alghasi , Roya Salehi Kahyesh * , Ali Rahimi , Saeed Bitaraf , Fatemeh Bineshfar
, Arash Alghasi , Roya Salehi Kahyesh * , Ali Rahimi , Saeed Bitaraf , Fatemeh Bineshfar
Abstract: (12 Views)
A B S T R A C T
Background and Objectives
Leukemia is the most common childhood malignancy, and disease relapse remains a major determinant of poor survival. Peripheral blood-related inflammatory markers, including lymphocyte-to-platelet ratio (LPR) and neutrophil-to-platelet ratio (NPR), have shown prognostic value in some adult cancers; however, their role in pediatric leukemia remains incompletely understood. This study aimed to investigate the association of LPR and NPR with relapse and survival in children with leukemia.
Materials and Methods
In this retrospective study over a six-year period, 230 children with various types of leukemia were enrolled, of whom 9 patients (3.9%) experienced a relapse. Demographic data including age, sex, blood group, and survival status (alive or deceased) were extracted from medical records. LPR and NPR values were calculated from complete blood count results. Statistical analyses were performed using the Mann-Whitney U test for continuous variables and Fisher's exact test for categorical variables. Regression analysis was also conducted to assess the association between clinical variables and inflammatory indices.
Results
The mean age of the relapse group (7.82±3.89 years) was higher than that of the non-relapse group (5.73±3.95 years), although this difference was not statistically significant (p=0.12). No significant association was found between relapse or survival with sex (p=0.82) or blood group (p=0.27). Patients with relapse had significantly poorer survival (p<0.001). In regression analysis, age showed a significant association with NPR (p=0.046), while LPR was not significantly associated with any clinical variable. Neither LPR nor NPR demonstrated predictive value for relapse or mortality.
Conclusions
Although NPR may be associated with some clinical features, neither LPR nor NPR independently predicted relapse or long-term survival. Prospective studies with larger sample sizes are necessary to further clarify the prognostic value of these markers.
Background and Objectives
Leukemia is the most common childhood malignancy, and disease relapse remains a major determinant of poor survival. Peripheral blood-related inflammatory markers, including lymphocyte-to-platelet ratio (LPR) and neutrophil-to-platelet ratio (NPR), have shown prognostic value in some adult cancers; however, their role in pediatric leukemia remains incompletely understood. This study aimed to investigate the association of LPR and NPR with relapse and survival in children with leukemia.
Materials and Methods
In this retrospective study over a six-year period, 230 children with various types of leukemia were enrolled, of whom 9 patients (3.9%) experienced a relapse. Demographic data including age, sex, blood group, and survival status (alive or deceased) were extracted from medical records. LPR and NPR values were calculated from complete blood count results. Statistical analyses were performed using the Mann-Whitney U test for continuous variables and Fisher's exact test for categorical variables. Regression analysis was also conducted to assess the association between clinical variables and inflammatory indices.
Results
The mean age of the relapse group (7.82±3.89 years) was higher than that of the non-relapse group (5.73±3.95 years), although this difference was not statistically significant (p=0.12). No significant association was found between relapse or survival with sex (p=0.82) or blood group (p=0.27). Patients with relapse had significantly poorer survival (p<0.001). In regression analysis, age showed a significant association with NPR (p=0.046), while LPR was not significantly associated with any clinical variable. Neither LPR nor NPR demonstrated predictive value for relapse or mortality.
Conclusions
Although NPR may be associated with some clinical features, neither LPR nor NPR independently predicted relapse or long-term survival. Prospective studies with larger sample sizes are necessary to further clarify the prognostic value of these markers.
Type of Study: Research |
Subject:
Hematology and Oncology
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