Volume 15, Issue 1 (Spring 2018)
Sci J Iran Blood Transfus Organ 2018, 15(1): 55-58 |
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Sabzikar E, Baghernejad neshel A, Hasani F, Kiani A, Alijani S, Nezami M et al . Identification of an Iranian family with Rh null phenotype . Sci J Iran Blood Transfus Organ 2018; 15 (1) :55-58
URL: http://bloodjournal.ir/article-1-982-en.html
URL: http://bloodjournal.ir/article-1-982-en.html
E. Sabzikar * 
, A. Baghernejad neshel , F. Hasani , A.A. Kiani , S. Alijani , M. Nezami , M. Emamifard
, A. Baghernejad neshel , F. Hasani , A.A. Kiani , S. Alijani , M. Nezami , M. Emamifard
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Identification of an Iranian family with Rh null phenotype
Sabzikar E.1,2, Baghernejad Nashl A.1,2, Hasani F.1, Kiani A.A.1,2, Alijani S.1,2, Nezami M.1,2
Emami Fard M.1,2
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Qazvin Regional Blood Transfusion Center, Qazvin, Iran
Abstract
Background and Objectives
Rh blood group system is one of the complex systems of blood groups and composed of nearly 50 antigens. The two gens of Rh D and Rh CE are responsible for coding of Rh system. Rh null genotype does not express any of these antigens. The prevalence of phenotype Rh null is 1 person per every 6×106 individuals and it is rather difficult to find compatible blood for the recipients in need. However, as there are probably members with similar characteristics in a given family, it would be plausible to diagnose the phenotype in family members to prepare compatible blood in time of need.
Case
In 2014, a 39-year-old negative female patient with hemolytic anemia referred to BoAli Hospital in Qazvin. Her sample, due to incompatibility in cross matching was further tested and her Rh null group was determined.
Conclusions
This case was identified by antibody screening tests and the subsequent determination of Rh antigen phenotype. After checking other family members, her brother was identified as the second Rh null group case in the country.
Key words: Blood Transfusion, Phenotype, Antigen, Iran
Received: 17 Aug 2015
Accepted: 3 Feb 2018
Correspondence: Sabzikar E., MSc of Hematology & Blood Banking. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Qazvin Regional Blood Transfusion Center.
Postal Code: 3416613445, Qazvin, Iran. Tel: (+9828) 12246727; Fax: (+9828) 12220136
E-mail:
sabzikar.seven1986@yahoo.com
Full-Text: (12842 Views)
References:
Caswell MS, Bergren MO, et al. Red cell membrane and cation deficiency in Rh null syndrome. Blood 1984; 63(5): 1046-55.
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Caswell MS, Bergren MO, et al. Red cell membrane and cation deficiency in Rh null syndrome. Blood 1984; 63(5): 1046-55.
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Sci J Iran Blood Transfus Organ 2018; 15(1): 55-58 |
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Case Report
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Identification of an Iranian family with Rh null phenotype
Sabzikar E.1,2, Baghernejad Nashl A.1,2, Hasani F.1, Kiani A.A.1,2, Alijani S.1,2, Nezami M.1,2
Emami Fard M.1,2
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Qazvin Regional Blood Transfusion Center, Qazvin, Iran
Abstract
Background and Objectives
Rh blood group system is one of the complex systems of blood groups and composed of nearly 50 antigens. The two gens of Rh D and Rh CE are responsible for coding of Rh system. Rh null genotype does not express any of these antigens. The prevalence of phenotype Rh null is 1 person per every 6×106 individuals and it is rather difficult to find compatible blood for the recipients in need. However, as there are probably members with similar characteristics in a given family, it would be plausible to diagnose the phenotype in family members to prepare compatible blood in time of need.
Case
In 2014, a 39-year-old negative female patient with hemolytic anemia referred to BoAli Hospital in Qazvin. Her sample, due to incompatibility in cross matching was further tested and her Rh null group was determined.
Conclusions
This case was identified by antibody screening tests and the subsequent determination of Rh antigen phenotype. After checking other family members, her brother was identified as the second Rh null group case in the country.
Key words: Blood Transfusion, Phenotype, Antigen, Iran
Received: 17 Aug 2015
Accepted: 3 Feb 2018
Correspondence: Sabzikar E., MSc of Hematology & Blood Banking. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Qazvin Regional Blood Transfusion Center.
Postal Code: 3416613445, Qazvin, Iran. Tel: (+9828) 12246727; Fax: (+9828) 12220136
E-mail:
sabzikar.seven1986@yahoo.com
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