Volume 12, Issue 3 (Autumn 2015)                   Sci J Iran Blood Transfus Organ 2015, 12(3): 233-243 | Back to browse issues page

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Ehsan M, Abroun S, Anjomshoaa A, Rezapour M, Rezaei Z. Association of alleles and haplotypes of HLA-A,-B,-DRB1 patients with Acute Myeloid Leukemia (AML) in Kerman province. Sci J Iran Blood Transfus Organ 2015; 12 (3) :233-243
URL: http://bloodjournal.ir/article-1-935-en.html
Association of alleles and haplotypes of HLA-A,-B,-DRB1 patients with Acute Myeloid Leukemia (AML) in Kerman province
M. Ehsan , S. Abroun * , A. Anjomshoaa , M. Rezapour , Z. Rezaei
Keywords: Key words : Acute Myeloid Leukemia, HLA-A, HLA DRB1, Allele Frequency
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Original  Article
 
 
 
 
Sci J Iran Blood Transfus Organ 2015; 12(3): 233-243
 
 

Association of alleles and haplotypes of HLA-A,-B,-DRB1
patients with Acute Myeloid Leukemia (AML)
in Kerman province
 
Ehsan M.1,2, Abroun S.1, Anjomshoaa A.2, Rezapour M.3, Rezaei Z.2
 
 
1Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2Faculty of Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran.
3Faculty of Math & Computer of Shahid Bahonar University, Kerman, Iran
 
 
 
 
Abstract
Background and Objectives
HLA system plays a key role in the cancer cells’escape from the immune surveillance. AML is a cancer of the myeloid lines of blood cells, characterized by the rapid growth of abnormal white blood cells in the bone marrow. Several studies worldwide have investigated the association of AML with alleles of HLA. This study was performed to assess the association between alleles of HLA-A, -B,-DRB1 with AML patients in Kerman province of Iran.
 
Materials and Methods
In the present case control study, alleles of HLA-A, -B, -DRB1 were molecularly typed using PCR-SSP technique in 33 AML patients and 270 healthy individuals unrelated with patients in province of Kerman, Iran. Finally, the data analysis was performed using c2 and SPSS 19.
 
Results
In this study, allelic frequency rates of HLA-A*11 in patient and control groups were 28.8% (19 cases) and 17% (92 cases), respectively; it indicates a significantly positive association between the presence of this allele and AML illness (p = 0.02, OR = 1.97 and CI (95%) = 1.10-3.51).
 
Conclusions
The presence of HLA-A* 11 in AML patients may be a predisposing factor for this disease to develop.
 
Key words: Acute Myeloid Leukemia, HLA-A, HLA DRB1, Allele Frequency
 
 
 
 
 
 
Received:    1 Feb 2015
Accepted: 24 May 2015
 
 
 

Correspondence: Abroun S., PhD of Hematology. Associate Professor of Faculty of Medical Sciences, Tarbiat Modares University.  
P.O.Box: 14155-331, Tehran, Iran. Tel: (+9821) 82883860; Fax : (+9821) 82884507
E-mail:
abroun@modares.ac.ir
Type of Study: Research | Subject: Imunohematology
Published: 2015/09/2
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