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Sci J Iran Blood Transfus Organ 2015, 11(1): 41-47 |
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Akbari N, Maghsudlu M, Tabibpour S, Mehran M, Sadeghi A, Ebrahimian A. Comparison of effectiveness of shot-time iron supplements with iron plus Vitamin C on compensating of Iron loss in female blood donors in Isfahan. Sci J Iran Blood Transfus Organ 2015; 11 (1) :41-47
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| Abstract (HTML) (9232 Views)
Comparison of effectiveness of shot-time iron supplements
with iron plus Vitamin C on compensating of Iron loss
in female blood donors in Isfahan
Akbari N.1,2, Maghsudlu M.1, Tabibpour S.H.1,2, Mehran M.1, Sadeghi A.1,2, Ebrahimian A.R.1,3
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Isfahan Regional Educational Blood Transfusion Center, Isfahan, Iran
3Tehran Regional Educational Blood Transfusion Center, Tehran, Iran
Abstract
Background and Objectives
Iron deficiency anemia might appear in donors particularly in women following blood donation. The present study compared the efficacy and consequences of iron intake compared with iron plus vitamin C supplements.
Materials and Methods
One hundred thirty eligible female donors were included in the study. The iron supplement group (IS) receiving 150 mg/day in a 10-day course of oral ferrous sulfate, divided in 3 doses were compared with the group who received iron supplement plus vitamin C (750 mg/day) in a 10-day course, divided in 3 doses, orally (AIS group). Ferritin, hemoglobin, hematocrit, serum iron, and total iron binding capacity (TIBC) were checked in both groups at the first visit before donation and 4 months after donation.
Results
TIBC levels increased in both groups of donors (p< 0.01). Ferritin level in IS group decreased (p= 0.036) from 25 ± 24 (ng/ml ) to 22 ± 21, and in AIS group (p= 0.031) from 16.5 ± 17 to 13.5 ± 13 after donation. Iron storage levels were similar in the both groups (p> 0.05). Gastrointestinal disturbances was seen in 9% (12) of supplement consumers. There are no differences between the two groups (p< 0.05).
Conclusions
Addition of Vitamin C to ferrous sulfate supplements neither had any impact on body iron load nor placed any adverse effects on blood donors. Moreover, the decline of ferritin level in all volunteers might be due both to the time duration between the first and the second sampling and the menstural period.
Key words: ferrous sulfate, Anemia, Iran, Blood Donors
Received: 3 Sep 2011
Accepted: 14 Oct 2013
Correspondence: Akbari N., MD. Blood Transfusion Research Center, High Institute for Research and Education in
Transfusion Medicine and Isfahan Regional Educational Blood Transfusion Center.
P.O. Box: 81688-44861, Isfahan, Iran. Tel: (+98311) 2607074; Fax : (+98311) 2607074
E-mail: nah_akbari@yahoo.com
Full-Text: (8811 Views)
References:
- Javadzadeh Shahshahani H, Attar M, Taher Yavari M. A study of the prevalence of iron deficiency and its related factors in blood donors of Yazd, Iran, 2003. Transfus Med 2005; 15(4): 287-93.
- Deyhim MR, Razjou F, Magsudlu M, Aghaii BA. Comparative evaluation of laboratory findings of iron deficiency anemia in first time and frequent female blood donors. Sci J Iran Blood Transfus Organ 2006; 3(2): 191-9. [Article in Farsi]
- Javadzadeh Shahshahani H, Attar M. The frequency of iron deficiency and the relevant factors in blood donors of Yazd Blood Center. Sci J Iran Blood Transfus Organ 2002; 1(2): 43-53. [Article in Farsi]
- Boulton F. Evidence-based criteria for the care and selection of blood donors, with some comments on the relationship to blood supply, and emphasis on the management of donation-induced iron depletion. Transfus Med 2008; 18(1): 13-27.
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- No authors listed. Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm Rep 1998; 47(RR-3): 1-29.
- Simon TL, Garry PJ, Hooper EM. Iron stores in blood donors. JAMA 1981; 245(20): 2038-43.
- Alvarez-Ossorio L, Kirchner H, Klüter H,, Schlenke P. Low ferritin levels indicate the need for iron supplementation: strategy to minimize iron-depletion in regular blood donors. Transfus Med 2000; 10(2): 107-12.
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- Maghsudlu M, Nasizadeh S, Toogeh GR, Zandieh T, Parandoush S, Rezayani M. Short-term ferrous sulfate supplementation in female blood donors. Transfusion 2008; 48(6): 1192–7.
- Radtke H, Tegtmeier J, Röcker L, Salama A, Kiesewetter H. Compensating for iron loss in regular blood donors using ferrous gluconate and ascorbic acid. Transfusion 2005; 45(7): 1236-7.
- Albockordi M, Mahmoudian A, Eshaghi R, Farajzadegan Z. Study of the effect of simultaneous iron, zinc and folic acid supplementation with or without vitamin A and C on hemoglobin levels of teenaged girl students in Shahinshahr city. Journal of Shahid Sadoughi University of Medical Sciences 2008; 16(1): 14-23. [Article in Farsi]
- Schrier SL, Auerbach M. Treatment of the adult with iron deficiency anemia. Available from: http://www.uptodate.com/contents/treatment-of-the-adult-with-iron-deficiency-anemia?source=search_result&search=Treatment+of+anemia+due+to+iron+deficiency+%2B+Schrier+SL&selectedTitle=1%7E150.
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Original Article
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Sci J Iran Blood Transfus Organ 2014; 11(1): 41-47 |
Comparison of effectiveness of shot-time iron supplements
with iron plus Vitamin C on compensating of Iron loss
in female blood donors in Isfahan
Akbari N.1,2, Maghsudlu M.1, Tabibpour S.H.1,2, Mehran M.1, Sadeghi A.1,2, Ebrahimian A.R.1,3
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Isfahan Regional Educational Blood Transfusion Center, Isfahan, Iran
3Tehran Regional Educational Blood Transfusion Center, Tehran, Iran
Abstract
Background and Objectives
Iron deficiency anemia might appear in donors particularly in women following blood donation. The present study compared the efficacy and consequences of iron intake compared with iron plus vitamin C supplements.
Materials and Methods
One hundred thirty eligible female donors were included in the study. The iron supplement group (IS) receiving 150 mg/day in a 10-day course of oral ferrous sulfate, divided in 3 doses were compared with the group who received iron supplement plus vitamin C (750 mg/day) in a 10-day course, divided in 3 doses, orally (AIS group). Ferritin, hemoglobin, hematocrit, serum iron, and total iron binding capacity (TIBC) were checked in both groups at the first visit before donation and 4 months after donation.
Results
TIBC levels increased in both groups of donors (p< 0.01). Ferritin level in IS group decreased (p= 0.036) from 25 ± 24 (ng/ml ) to 22 ± 21, and in AIS group (p= 0.031) from 16.5 ± 17 to 13.5 ± 13 after donation. Iron storage levels were similar in the both groups (p> 0.05). Gastrointestinal disturbances was seen in 9% (12) of supplement consumers. There are no differences between the two groups (p< 0.05).
Conclusions
Addition of Vitamin C to ferrous sulfate supplements neither had any impact on body iron load nor placed any adverse effects on blood donors. Moreover, the decline of ferritin level in all volunteers might be due both to the time duration between the first and the second sampling and the menstural period.
Key words: ferrous sulfate, Anemia, Iran, Blood Donors
Received: 3 Sep 2011
Accepted: 14 Oct 2013
Correspondence: Akbari N., MD. Blood Transfusion Research Center, High Institute for Research and Education in
Transfusion Medicine and Isfahan Regional Educational Blood Transfusion Center.
P.O. Box: 81688-44861, Isfahan, Iran. Tel: (+98311) 2607074; Fax : (+98311) 2607074
E-mail: nah_akbari@yahoo.com
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