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The prevalence of platelet function defects in patients referred to the special reference coagulation laboratory of Iranian Blood Transfusion Organization
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A. Rajabi   , M. Ahmadinejad , M. Mashkooli , S.M.R. Tabatabaie , S.L. Seyed Mortaz , S. Ran-Balooch , S.S. Moazezi Nekoui-Asl , Z. Mokhtari , M. Mojtabavi Naeini |
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| Keywords: Key words: Blood Platelet Disorders, Platelet Function Tests, Platelet Aggregation, Bernard-Soulier Syndrome, Thrombasthenia |
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Type of Study: Research |
Subject:
Hematology
Published: 2014/03/16
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Full-Text: (16221 Views) |
References:
- Hayward CP. Diagnostic approach to platelet function disorders. Transfus Apheresis Sci 2008; 38(1): 65-76.
- Zhou L, Schmaier AH. Platelet aggregation testing in platelet-rich plasma : description of procedures with the aim to develop standards in the field. Am J Clin Pathol 2005; 123(2): 172-83.
- Hayward CP, Eikelboom J. Platelet function testing: quality assurance. Semin Thromb Hemost 2007; 33(3): 273-82.
- Charo IF, Feinman RD, Detwiler TC. Interrelations of platelet aggregation and secretion. J Clin Invest 1977; 60(4): 866-73.
- Clinical and Laboratory Standards Institute. Platelet Function Testing by Aggregometry; Approved Guideline. Available from: http://shopping.netsuite.com/c.1253739/site/Sample_pdf/H58A_sample.pdf.
- White MM, Foust JT, Mauer AM, Robertson JT, Jennings LK. Assessment of lumiaggregometry for research and clinical laboratories. Thromb Haemost 1992; 67(5): 572-7.
- Hayward CP. Diagnostic evaluation of platelet function disorders. Blood Rev 2011; 25(4): 169-73.
- Razjou F. Glanzmann’s thrombasthenia in Iran. Journal of Qazvin University of Medical Sciences 2001; 5(2): 52-8. [Article in Farsi]
- Shams Asanjan K. A survey on platelet surface glycolproteins in patients with Bernard-Souliar syndrome by flowcytometry . Journal of Qazvin University of Medical Sciences 2005; 8(4): 21-6. [Article in Farsi]
- Afrasiabi A, Lecchi A, Artoni A, Karimi M, Ashouri E, Peyvandi F, et al. Genetic characterization of patients with Bernard-Soulier syndrome and their relatives from Southern Iran. Platelets 2007; 18(6): 409-13.
- Farsinejad A, Abolghasemi H, Kazemi A, Aghaiipour M, Hadjati E, Faranoush M, et al. Classification of Iranian patients with Glanzmann’s Thrombasthenia using a flow cytometric method. Platelets 2011; 22(5): 321-7.
- Tosetto A, Castaman G, Rodeghiero F. Assessing bleeding in von Willebrand disease with bleeding score. Blood Rev 2007;21(2): 89-97.
- D'Andrea G, Chetta M, Margaglione M. Inherited platelet disorders: thrombocytopenias and thrombocytopathies. Blood transfuse 2009; 7(4): 278-92.
- Khanduri U, Pulimood R, Sudarsanam A, Carman RH, Jadhav M, Pereira S. Glanzmann's thrombasthenia. A review and report of 42 cases from South India. Thromb Haemost 1981; 46(4): 717-21.
- Nurden AT. Glanzmann thrombasthenia. Orphanet J Rare Dis 2006; 1: 10.
- Seligsohn U, Rososhansky S. A Glanzmann’s thrombasthenia cluster among Iraqi Jews in Israel. Thromb Haemost 1984; 52(3): 230-1.
- Awidi AS. Increased incidence of Glanzmann’s thrombasthenia in Jordan as compared with Scandinavia. Scand J Haematol 1983; 30(3): 218-22.
- Lanza F. Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy). Orphanet J Rare Dis 2006; 1: 46.
- Hayward CP. Inherited platelet disorders. Curr Opin Hematol 2003; 10(5): 362-8.
- Harrison P. Progress in the assessment of platelet function. Br J Haematol 2000; 111(3): 733-44.
- Moffat KA, Ledford-Kraemer MR, Nichols WL, Hayward CP ; North American Specialized Coagulation Laboratory Association. Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North America Specialized Coagulation Laboratory Association. Thromb Haemost 2005; 93(3): 549-53.
- Rao Ak. Inherited defects in platelet signaling mechanisms. J Thromb Haemost 2003; 1(4): 671-81.
- Cattaneo M. Inherited platelet-based bleeding disorders. J Thromb Haemost 2003; 1(7): 1628-36.
- Santos XM, Bercaw-Pratt JL, Yee DL, Dietrich JE. Recurrent menorrhagia in an adolescent with a platelet secretion defect. J Pediatr Adolesc Gynecol 2001; 24(2): e35-8.
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Sci J Iran Blood Transfus Organ 2014; 11(1): 23-31
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The prevalence of platelet function defects in patients
referred to the special reference coagulation laboratory of Iranian Blood Transfusion Organization
Rajabi A.1, Ahmadinejad M.1, Mashkooli M.1, Tabatabaei S.M.R.1, Seyed Mortaz S.L.1,
Ran-Balooch S.1, Moazezi Nekoui-Asl S.S.1, Mokhtari Z.1, Mojtabavi Naeini M.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Abstract
Background and Objectives
Platelet function disorders are common in the world population but in our country except for severe cases, they are not well investigated due to limited diagnostic tools. In recent two years we aimed to assess platelet function tests in referral patients suspected of platelet function disorders, in the special reference coagulation laboratory of Iranian Blood Transfusion Organization, as the center equipped with lumi-aggregometer.
Materials and Methods
We have investigated 195 referral patients during a seven-month period, from November 2011 to May 2012, for platelet aggregation and ATP release response for highly suspected patients with four platelet agonists ADP, collagen, arachidonic acid and ristocetin and a luciferin-luciferase reagent. Results were analyzed by SPSS version 16.
Results
Among 195 referred patients, 90 cases (46.1%) had an abnormality in platelet count or function. Abnormal cases fall within the categories of low platelet count with normal function (8.2%), ATP release (secretion) defect (6.7%), Glanzman's thrombastenia (4.6%), Bernard Solier Syndrome (2%), acquired platelet defect (1.5%), afibrinogenemia (0.5%), and uncategorized platelet function disorders (22.6%). The other 105 remaining patients showed a quiet normal result.
Conclusions
The present study is the first simultaneous analysis of platelet function and secretion disorders. In order to guess the true prevalence of these disorders, more wider and comprehensive studies, the use of more complete panels of agonists and ATP release assessment in all patients with an abnormal aggregometry pattern have been suggested for future studies.
Key words: Blood Platelet Disorders, Platelet Function Tests, Platelet Aggregation, Bernard-Soulier Syndrome, Thrombasthenia
Received: 7 May 2013
Accepted: 11 Aug 2013
Correspondence: Ahmadinejad M., MD. Pathologist. Assistant Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88212459; Fax: (+9821) 88601555
E-mail: minooam26@yahoo.com
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Rajabi A, Ahmadinejad M, Mashkooli M, Tabatabaie S, Seyed Mortaz S, Ran-Balooch S, et al . The prevalence of platelet function defects in patients referred to the special reference coagulation laboratory of Iranian Blood Transfusion Organization. Sci J Iran Blood Transfus Organ 2015; 11 (1) :23-31 URL: http://bloodjournal.ir/article-1-851-en.html
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