Volume 10, Issue 3 (Autumn 2013)
Sci J Iran Blood Transfus Organ 2013, 10(3): 297-304 |
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Beshkar P, Poorgheisari B, Khosravi M. The evaluation of the causes of occurrence of beta thalassemia major after the control program in patients having referred to Hajar Hospital. Sci J Iran Blood Transfus Organ 2013; 10 (3) :297-304
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The evaluation of the causes of occurrence of beta
thalassemia major after the control program in patients
having referred to Hajar Hospital
Beshkar P.1, Poorgheisari B.2, Khosravi M.2
1Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Background and Objectives
Major β-thalassemia is one of the most problematic diseases both for patients and their families as well as for health services. The number of major thalassemia cases born in 1988 was reported to be 1200 which reduced to 250 in 2007. In spite of the success of the screening program, we still experience some new cases of β-thalassemia. This study aimed to investigate the causes of occurrence of new affected infants to help the prevention program.
Materials and Methods
In this descriptive analytic study, the parents of β-thalassemia patients having referred were investigated. EDTA blood samples were used for CBC, electrophoresis, and Hb A2 measurment. Simultaneously, the participants were asked to fill out the prepared questionnaire for the causes of occurrence to be evaluated. CBC was performed by sysmex XS800i, electrophoresis by cellulose acetate, and Hb A2 by column chromatography.
Results
Sixty eight couples, as the parents of 78 patients with major thalassemia, participated in the project. Out of the total number of patients, 20 (25.6%) were under 13 years of age out of whom 7 , 2 and 11 were addressed by the first, second, and third strategies, respectively. Four patients were born due to being left undiagnosed or misdiagnosed due to error in screening and pre-natal tests.
Conclusions
In order to minimize the occurrence of new cases, we should promote the education and awareness in underdeveloped and non-urban communities. The couples should be identified and directed. The financial support and the possibility of on time testing could be helpful.
Key words: Thalassemia, screening, Hemoglobin
Received : 26 Jun 2012
Accepted: 21 Oct 2012
Correspondence: Beshkar P., MSc of Hematology. Cellular and Molecular Research Center, Shahrekord University of Medical Sciences.
Postal Code: 8813833435, Shahrekord, Iran. Tel: (+98381) 3335652-4; Fax : (+98381) 3334911
E-mail:
beshkarpezhman@yahoo.com
Full-Text: (12287 Views)
References :
- Thalassemia International Federation. Guidelines for the Clinical Management of Thalassemia: The thalassemia overview. USA: Thalassemia International Federation; 2000. p. 1-2.
- Noshad S. [Harrison's Principles of Internal Medicine]. Tehran: Andisheh Publications; 2009. p. 93-6.
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- Zeinalian M, Samavat A, Fadayee Nobari R, Azin SA. Incidence rate of major beta-thalassemia and study of its causes after prevention and control program of thalassemia in Isfahan Province. Sci J Iran Blood Transfus Organ 2010; 6(4): 238-47. [Article in Farsi]
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Original Article
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Sci J Iran Blood Transfus Organ 2013; 10(3): 297-304 |
The evaluation of the causes of occurrence of beta
thalassemia major after the control program in patients
having referred to Hajar Hospital
Beshkar P.1, Poorgheisari B.2, Khosravi M.2
1Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Background and Objectives
Major β-thalassemia is one of the most problematic diseases both for patients and their families as well as for health services. The number of major thalassemia cases born in 1988 was reported to be 1200 which reduced to 250 in 2007. In spite of the success of the screening program, we still experience some new cases of β-thalassemia. This study aimed to investigate the causes of occurrence of new affected infants to help the prevention program.
Materials and Methods
In this descriptive analytic study, the parents of β-thalassemia patients having referred were investigated. EDTA blood samples were used for CBC, electrophoresis, and Hb A2 measurment. Simultaneously, the participants were asked to fill out the prepared questionnaire for the causes of occurrence to be evaluated. CBC was performed by sysmex XS800i, electrophoresis by cellulose acetate, and Hb A2 by column chromatography.
Results
Sixty eight couples, as the parents of 78 patients with major thalassemia, participated in the project. Out of the total number of patients, 20 (25.6%) were under 13 years of age out of whom 7 , 2 and 11 were addressed by the first, second, and third strategies, respectively. Four patients were born due to being left undiagnosed or misdiagnosed due to error in screening and pre-natal tests.
Conclusions
In order to minimize the occurrence of new cases, we should promote the education and awareness in underdeveloped and non-urban communities. The couples should be identified and directed. The financial support and the possibility of on time testing could be helpful.
Key words: Thalassemia, screening, Hemoglobin
Received : 26 Jun 2012
Accepted: 21 Oct 2012
Correspondence: Beshkar P., MSc of Hematology. Cellular and Molecular Research Center, Shahrekord University of Medical Sciences.
Postal Code: 8813833435, Shahrekord, Iran. Tel: (+98381) 3335652-4; Fax : (+98381) 3334911
E-mail:
beshkarpezhman@yahoo.com
Send email to the article author
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