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Sci J Iran Blood Transfus Organ 2015, 11(1): 87-92 |
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Ghezelbash B, Moghaddam M. A case report of a patient with multiple warm and cold agglutinin with strong clinical importance. Sci J Iran Blood Transfus Organ 2015; 11 (1) :87-92
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URL: http://bloodjournal.ir/article-1-778-en.html
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| Abstract (HTML) (8323 Views)
A case report of a patient with multiple warm and
cold agglutinin with strong clinical importance
Ghezelbash B.1,2, Moghaddam M.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Ardabil Regional Educational Blood Transfusion Center, Ardabil, Iran
Abstract
Background and Objectives
The unexpected alloantibodies are usually found in the sera of those patients who have a history of blood transfusion and pregnancy. These alloantibodies cause many complications in patients with post-transfusion delayed hemolytic transfusion reactions.
Case
A 24-year-old man with melana, blood vomiting, and the history of discopathy and consumption of moleksicam was observed. In laboratory tests, incompatibility of the cross-match test and discrepancy of blood grouping were observed. In the analysis of the antibody screening, positive reactions were observed with all of the cells in different phases of panels 3 and 11. On the next visit, similar results were obtained after 6 months.
Conclusions
If indicated for blood transfusion, only autologous blood is recommended to be administered to prevent hemolytic transfusion reactions.
Key words: Blood Transfusion, Agglutination, cold agglutinins
Received: 17 Aug 213
Accepted: 7 Dec 2013
Correspondence: Ghezelbash B. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Ardabil Regional Educational Blood Transfusion Center.
Postal Code: 5613774111, Ardabil, Iran. Tel: (+98451) 3361408; Fax: (+98451) 3361409
E-mail: behruzghezelbash@yahoo.com
Full-Text: (2626 Views)
References:
- Huh YO. Pretransfusion Testing of Red Blood Cells: Current Status. Current Issues in Transfusion Medicine 1994; 3(1): 216-20.
- Fluit CR, Kunst VA, Dernthe-Schonk AM. Incidence of red cell antibodies after multiple blood transfusion. Transfusion 1990; 30(6): 532-5.
- Schonewille H, Haak HL, Van Zijl AM. Alloimmunization after blood transfusion in patients with hematologic and oncologic diseases. Transfusion 1999; 39(7): 763-71.
- Redman M, Regan F, Contreras M. A prospective study of the incidence of red cell allo-immunisation following transfusion. Vox Sang 1996; 71(4): 216-20.
- Tormey CA, Fisk J, Stack G. Red blood cell
- Azarkeivan A, Ahmadi MH, Gharehbaghian A, Zolfaghari S, Nasizadeh S, Maghsudlu M, et al. Antibody screening and identification by gel method in thalassemic patients. Sci J Iran Blood Transfus Organ 2008; 5(2): 99-108. [Article in Farsi]
- Ghorbani Ali-Abadi E, Tavassoli AR, Gharehbaghian A, Kasraian L, Khademi R, Taleie A. Evaluation of frequency and specificity of RBC alloantibodies in Namazi Hospital patients in Shiraz, 2010. Sci J Iran Blood Transfus Organ 2013; 10(3): 239-45. [Article in Farsi]
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Case Report
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Sci J Iran Blood Transfus Organ 2014; 11(1): 87-92 |
A case report of a patient with multiple warm and
cold agglutinin with strong clinical importance
Ghezelbash B.1,2, Moghaddam M.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Ardabil Regional Educational Blood Transfusion Center, Ardabil, Iran
Abstract
Background and Objectives
The unexpected alloantibodies are usually found in the sera of those patients who have a history of blood transfusion and pregnancy. These alloantibodies cause many complications in patients with post-transfusion delayed hemolytic transfusion reactions.
Case
A 24-year-old man with melana, blood vomiting, and the history of discopathy and consumption of moleksicam was observed. In laboratory tests, incompatibility of the cross-match test and discrepancy of blood grouping were observed. In the analysis of the antibody screening, positive reactions were observed with all of the cells in different phases of panels 3 and 11. On the next visit, similar results were obtained after 6 months.
Conclusions
If indicated for blood transfusion, only autologous blood is recommended to be administered to prevent hemolytic transfusion reactions.
Key words: Blood Transfusion, Agglutination, cold agglutinins
Received: 17 Aug 213
Accepted: 7 Dec 2013
Correspondence: Ghezelbash B. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Ardabil Regional Educational Blood Transfusion Center.
Postal Code: 5613774111, Ardabil, Iran. Tel: (+98451) 3361408; Fax: (+98451) 3361409
E-mail: behruzghezelbash@yahoo.com
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