Volume 11, Issue 3 (Autumn 2014)                   Sci J Iran Blood Transfus Organ 2014, 11(3): 230-238 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

keyhanian S, Janat Alipoor Z, Zahirian Moghaddam H, Fotoukian Z, Omrani Nava M, Saravi M. A study of fever causes in neutropenic patients hospitalized in oncology ward of Imam-Sajjad Hospital in Ramsar . Sci J Iran Blood Transfus Organ 2014; 11 (3) :230-238
URL: http://bloodjournal.ir/article-1-747-en.html
Full-Text [PDF 309 kb]   (3758 Downloads)     |   Abstract (HTML)  (8713 Views)
Full-Text:   (27479 Views)
References:
 
  1. Mandell GL, Douglas RG, Bennett JE. Principles and practice of infectious Diseases. 6th ed. Philadelphia: Churchill Livingstone; 2005. p. 3427-9.
  2. Feld R, DePauw B, Berman S, Keating A, Ho W. Meropenem versus ceftazidime in the treatment of cancer patients with febrile neutropenia: a randomized, double-blind trial. J Clin Oncol 2000; 18(21): 3690-8.
  3. Klastersky J. Management of fever in neutropenic patients with different risks of complications. Clin Infect Dis 2004; 39 Suppl 1: 32-7.
  4. Viscoli C, Varnier O, Machetti M. Infections in patients with febril Neutropenia: epidemiology, microbiology, and risk stratification. Clin Infect Dis 2005; 40 Suppl 4: S240-5.
  5. Gelfand JA, Callahan MV. Fever of unknown origin. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Gelfand JA, et al. Harrisons Principles of Internal Medicine. 16th ed. New York: Mc Graw-Hill; 2005. p. 116-20.
  6. Ilami O, Salari Shahrebabaki MR , Shoaei S, Gachkar L. Fever of unknown origin, a prospective multicenter study of patients with FUO in hospitals of Shahid Beheshti University of Medical Sciences in 2003. Armaghane Danesh 2012; 12(1): 118-22. [Article in Farsi]
  7. Lyman GhKuderer NM. Epidemiology of febrile neutropenia. Support Cancer Ther 2003; 1(1): 23-35.
  8. Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, et al. 2002 guidelines  for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002; 34(6): 730-51.
  9. Coller BS, Kipps Th.J, Beutler E, Lichtman MA.Williams Hematology. 6th ed. New York:   Mcgraw-Hill; 2001. p. 817-27, 881-2.
  10. Tamai Y, Imataki O, Kawakami K. Fever profile of febrile neutropenia in patients treated with cancer chemotherapy for hematological malignancies. Gan To Kagaku Ryoho 2010; 37(5): 859-62. [Article in Japanese]
 
 
  1. Barton TD, Schuster MG. The cause of fever following resolution of neutropenia in patients with acute leukemia. Clin Infect Dis 1996; 22(6): 1064-8.
  2. Rosenthal VD, Maki DG, Graves N. The International Nosocomia Infection Control Consortium (INICC): goals and objectives, description of surveillance methods, and operational activities. Am J Infect Control 2008; 36(9): e1-12.
  3. Rolston KV. Challenges in the treatment of infections caused by gram-positive and gram-negative bacteria in patients with cancer and neutropenia. Clin Infect Dis 2005; 40 Suppl 4: S246-52.
  4. Klastersky J, Paesmans M, Georgala A, Muanza F, Plehiers B, Dubreucq L, et al. Outpatient oral antibiotics for febrile neutropenic cancer patients using a score predictive for complications. J Clin Oncol 2006; 24(25): 4129-34.
  5. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis 2011; 52(4): e56-93.
  6. Pizzo PA. Management of fever in patients with cancer and treatment-induced neutropenia. N Engl J Med 1993; 328(18): 1323-32.
  7. Sipsas NV, Bodey GP, Kontoyiannis DP. Perspectives for the management of febrile neutropenic patients with cancer in the 21st century. Cancer 2005; 103(6): 1103-13.
  8. Rasool Hassan BA, Yusoff ZB, Othman SB. Fever/clinical signs and association with neutropenia in solid cancer patients--bacterial infection as the main cause. Asian Pac J Cancer Prev 2010; 11(5): 1273-7.
  9. Hosseini  MJ, Rangbar R, Saadat A, Soleimani R, hasemi R. A Study on the prevalence and etiology of fever in hospitalized patients with fever and neutropenia in Baqyiatallah  hospital  during  1995-2005. Journal of  Ilam  University of  Medical  Sciences 2006; 14(3): 8-11. [Article in Farsi]
 
 


 
 
Original Article
 
 
 
 
Sci J Iran Blood Transfus Organ 2014; 11(3): 230-238
 
A study of fever causes in neutropenic patients
hospitalized in oncology ward of Imam-Sajjad Hospital
in Ramsar
 
Keyhanian Sh.1, Jannat Alipoor Z.2, Zahirian Moghaddam H.1, Fotoukian Z.2,
Omrani Nava M.1, Saravi M.M.4
 
 
1Tonekabon Islamic Azad University, Tonekabon, Iran
2Faculty of Nursing & Midwifery, Babol University of Medical Sciences, Ramsar, Iran
3Babol University of Medical Sciences, Babol, Iran
4Mazandaran University of Medical Sciences, Ramsar, Iran
 
 
Abstract
Background and Objectives
Neutropenia is the strongest factor associated with infection in neutropenic patients with immunodeficiency and under immunosuppressive medication with fever being the most important indicator of infection in neutropenic patients. Since infections are the commonest cause of death in these patients, this study was performed to determine the causes of fever in neutropenic patients.
 
Materials and Methods
This cross-sectional study was performed on 63 patients hospitalized with febrile neutropenia, admitted in the oncology ward of Imam Sajjad Hospital during 2006-2011. Sampling was performed by available sampling techniques and data collection was performed by checklist. The data were analyzed using statistical software SPSS 16. The significance level was considered to be less than 0.05 in this study.
 
Results
Out of the total number of patients, 39.7% were male and 60.3% female. The mean age of patients was 51.83 ± 17.06 years.  Culture was positive in 54% patients (33.36% F, 20.64% M). The most common types of infection were urinary tract (14.3%) and respiratory infections (7.9%). The most common isolated microorganism was Escherichia Coli (26.5%).
 
Conclusions 
The findings of most studies show that gram-positive bacteria are the most common cause of fever in neutropenic patients.
 
Key words: Fever, Neutropenia, Infection
 
 
 
 
 
Received: 13 May 2013
Accepted: 11 Nov 2013
 
 
 

Correspondence: Jannat Alipoor Z., MSc of Nursing Education. Faculty of Nursing & Midwifery, Babol University of Medical Sciences.
P.O.Box: 51515, Ramsar, Iran. Tel: (+9811) 55225151; Fax: (+9811) 55226413
E-mail:
 zalipoor@gmail.com
Type of Study: Research | Subject: Infectious disease
Published: 2014/09/29

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Scientific Journal of Iran Blood Transfus Organ

Designed & Developed by : Yektaweb