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Zeinalian M, Moafi A, Fadayi-Nobari R. A study to evaluate the results of pre-marital screening program for beta-thalassemia in Isfahan province, 1997-2010. Sci J Iran Blood Transfus Organ 2013; 10 (1) :20-30
URL: http://bloodjournal.ir/article-1-736-en.html
A study to evaluate the results of pre-marital screening program for beta-thalassemia in Isfahan province, 1997-2010
M. Zeinalian * , A.R. Moafi , R. Fadayi-Nobari
Keywords: Key words: beta-Thalassemia, screening, Iran
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Original Article
 
 
 
 
Sci J Iran Blood Transfus Organ 2013; 10 (1): 20-30
 
 
 

A study to evaluate the results of pre-marital
screening program for beta-thalassemia in Isfahan
province, 1997-2010
 
 
Zeinalian M.1, Moafi A.R.2, Fadayi-Nobari R.3
 
 
1Shahrekord University of Medical Sciences, Shahrekord, Iran
2Isfahan University of Medical Sciences, Isfahan, Iran
3Center for Disease Control and Prevention of Isfahan University of Medical Sciences, Isfahan, Iran
 
 
 
Abstract
Background and Objectives
Pre-marital screening program for beta-thalassemia is one of the most important preventive programs in Iranian health system. The results of this program in Isfahan province have been evaluated within 1376-89 (1997-2010) in the present article.
 
Materials and Methods
The method of this study is descriptive and cross-sectional using the current data, received from districts health centers of Isfahan province within 1376-89 (1997-2010). Then we analyzed the data by using SPSS-19 and Excel softwares.
 
Results
Out of 616,457 potential couples screened in pre-marital screening centers, 1194 (0.19%) were considered to be definite carriers of beta-thalassemia (HbA2>3.5 in both partners), and 3314 couples (0.63%) suspicious for. The incidence rate of the disease decreased from 43.7 cases/100,000 live births in 1376 to 1.5 cases/100,000 live births in 1389. The most prevalent causes of new cases were estimated to be marriage of parents before commencement of the program (51%), family values and cultural backgrounds (15%), genetic counseling defects (9%), health care defects (6%), and screening test errors (5%).
 
Conclusions 
We conclude that some health-related interventions are required to be made. Promoting genetic counseling, following up suspicious or carrier couples with no screening record, community awareness raising about prevention program of thalassemia especially among students and marriage officers.
 
Key words: beta-Thalassemia, screening , Iran
 
 
 
Received: 30  Apr 2012
Accepted: 21 Aug 2012
 
 
 

Correspondence: Zeinalian M., MD, MPH. PhD Student of Molecular Medicine. Shahrekord University of Medical Sciences. Kashani Blv., Shahrekord.
Postal code: 8815713471, Shahrekord, Iran. Tel: (+98381) 3338047; Fax: (+98381) 3338047
E-mail:
zeinalian_mehrdad@yahoo.com
Type of Study: Research | Subject: Hematology
Published: 2013/08/14
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