Volume 2, Issue 7 (Winter-blood saftey supplement 2006)
Sci J Iran Blood Transfus Organ 2006, 2(7): 291-299 |
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Torabi S.A., Abed-Ashtiani K., Dehkada R., Moghadam A.N., Bahram M.Kh., Dolatkhah R., et al . Prevalence of hepatitis B, C and HIV in hemophiliac patients of East Azarbaijan in 2004. Sci J Iran Blood Transfus Organ 2006; 2 (7) :291-299
URL: http://bloodjournal.ir/article-1-47-en.html
URL: http://bloodjournal.ir/article-1-47-en.html
Torabi S.A. * 
, Abed-Ashtiani K. , Dehkada R. , Moghadam A.N. , Bahram M.Kh. , Dolatkhah R. , Babaei J. , Taheri N.
, Abed-Ashtiani K. , Dehkada R. , Moghadam A.N. , Bahram M.Kh. , Dolatkhah R. , Babaei J. , Taheri N.
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Prevalence of hepatitis B, C and HIV in hemophiliac patients
of East Azarbaijan in 2004
Torabi S.A.1,2(MS), Abed-Ashtiani K.1,2(MS), Dehkada R.1,2(MD), Moghadam A.N.1,2(MD),
Bahram M.Kh.1,2(BS), Dolatkhah R.3(MD), Babaei J.1,2(BS), Taheri N.4(BS)
1 Iranian Blood Transfusion Organization-Research Center
2 Tabriz Regional Educational Blood Center
3 Shahid Qazi Tabatabaei Hospital-Tabriz
4 Hemophilia Center of East Azerbaijan Province
Abstract
Background and Objectives
Due to frequent tranfusion of blood components, hemophiliac patients have been exposed to a wide range of blood-borne viruses, among which the human immune deficiency virus (HIV) and the hepatitis C virus (HCV) have had a considerable impact on their life. Prior to the introduction of virus-inactivation methods in 1985, almost all treated hemophiliacs had been infected with HCV transmited by factor concentrates, and in most countries almost 50% of hemophiliacs had also been infected with HIV.
Materials and Methods
162 patients with inherited coagulation disorders including 113 hemophilia A and 17 hemophilia B patients living in East Azarbaijan participated in this observational study. The patients started to be tested for anti-HCV, anti-HIV, and HBs-Ag in 2003. Demographic information were gathered through questionnaires and some other information was taken from patients' medical records.
Results
Among 113 hemophilia A and 17 hemophilia B patients, 63 (56%) and 9 (53%) were seropoitive for HCV-Ab respectively. The youngest patient who was seropositive for HCV-Ab was eleven years old, and his first blood transfusion occurred in 1993. No child under the age of 10 was HCV positive; in other words, there was no case of HCV in 1995 (P<0.001). In hemophilia A group one patient (0.9%) was seropositive for HIV and 3 (2.7%) were seropositive for HBs-Ag. HCV status was also related to baseline factor activity level. In more severely affected patients of both group A and B (< 1% factor activity) , the prevalence of HCV was 75%.
Conclusions
Hemophiliac patients born after 1995 have no evidence of HIV infection. Only one patient (0.9%) was seropositive for HIV and in this respect our province as compared with other countries is in a good condition.
Key words: Hemophilia, Hepatitis C, Hepatitis B, HIV
SJIBTO 2006; 2(7): 291-299
Received: 18 Oct 2004
Accepted:17 May 2005
Correspondence: Torabi , S.E., MS of Parazitology, IBTO- Research Center
P.O.Box: 1888, Tabriz, Iran.Tel: (+98411)5563017 ; Fax : (+98411)5564666
E-mail: Seydesmail@yahoo.com
of East Azarbaijan in 2004
Torabi S.A.1,2(MS), Abed-Ashtiani K.1,2(MS), Dehkada R.1,2(MD), Moghadam A.N.1,2(MD),
Bahram M.Kh.1,2(BS), Dolatkhah R.3(MD), Babaei J.1,2(BS), Taheri N.4(BS)
1 Iranian Blood Transfusion Organization-Research Center
2 Tabriz Regional Educational Blood Center
3 Shahid Qazi Tabatabaei Hospital-Tabriz
4 Hemophilia Center of East Azerbaijan Province
Abstract
Background and Objectives
Due to frequent tranfusion of blood components, hemophiliac patients have been exposed to a wide range of blood-borne viruses, among which the human immune deficiency virus (HIV) and the hepatitis C virus (HCV) have had a considerable impact on their life. Prior to the introduction of virus-inactivation methods in 1985, almost all treated hemophiliacs had been infected with HCV transmited by factor concentrates, and in most countries almost 50% of hemophiliacs had also been infected with HIV.
Materials and Methods
162 patients with inherited coagulation disorders including 113 hemophilia A and 17 hemophilia B patients living in East Azarbaijan participated in this observational study. The patients started to be tested for anti-HCV, anti-HIV, and HBs-Ag in 2003. Demographic information were gathered through questionnaires and some other information was taken from patients' medical records.
Results
Among 113 hemophilia A and 17 hemophilia B patients, 63 (56%) and 9 (53%) were seropoitive for HCV-Ab respectively. The youngest patient who was seropositive for HCV-Ab was eleven years old, and his first blood transfusion occurred in 1993. No child under the age of 10 was HCV positive; in other words, there was no case of HCV in 1995 (P<0.001). In hemophilia A group one patient (0.9%) was seropositive for HIV and 3 (2.7%) were seropositive for HBs-Ag. HCV status was also related to baseline factor activity level. In more severely affected patients of both group A and B (< 1% factor activity) , the prevalence of HCV was 75%.
Conclusions
Hemophiliac patients born after 1995 have no evidence of HIV infection. Only one patient (0.9%) was seropositive for HIV and in this respect our province as compared with other countries is in a good condition.
Key words: Hemophilia, Hepatitis C, Hepatitis B, HIV
SJIBTO 2006; 2(7): 291-299
Received: 18 Oct 2004
Accepted:17 May 2005
 |
Correspondence: Torabi , S.E., MS of Parazitology, IBTO- Research Center
P.O.Box: 1888, Tabriz, Iran.Tel: (+98411)5563017 ; Fax : (+98411)5564666
E-mail: Seydesmail@yahoo.com
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