Volume 21, Issue 3 (Autumn 2024)
Sci J Iran Blood Transfus Organ 2024, 21(3): 180-190 |
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Teimourpour A, Mpghtadaee M, Amini- kafiabad S, Maghsoodlu M, Rafiee M. Investigating the trend of look-back units in the plasma for contract fractionation during 2018-2021. Sci J Iran Blood Transfus Organ 2024; 21 (3) :180-190
URL: http://bloodjournal.ir/article-1-1554-en.html
URL: http://bloodjournal.ir/article-1-1554-en.html
Investigating the trend of look-back units in the plasma for contract fractionation during 2018-2021
High Institute for Education and Research for Blood Transfusion Medicine
Abstract: (550 Views)
Abstract
Background and Objectives
In addition to supplying safe and sufficient blood and blood components, Iranian Blood Transfusion Organization (IBTO) has supplied surplus plasma for plasma fractionation to produce plasma-derived medicine products (PDMPs) since 2005. The look-back process is a requirement for contract fractionation and aims to improve the safety of PDMPs and blood components. This study investigates the trend of look-back units due to repeatedly reactive screening test results during 2018-2021.
Materials and Methods
In this serial cross-sectional study, the data gathered from the look-back form, including the number of lookback cases, lookback due to repeatedly reactive samples, confirmatory test results, and changes in test kits. The data were entered into SPSS software, and statistical analysis were carried out using the chi-square test and incidence rate ratio in R software.
Results
In 2019, after changing the screening methods and kits, there was a significant increase in the look-back rate and the number of repeatedly reactive samples in screening tests. The prevalence of repeatedly reactive samples in the HBsAg screening test was lower than that of HIV and HCV. The confirmatory test showed negative results for HCV and HIV at rates of 85% and 90%, respectively.
Conclusions
The change in screening methods and kits can lead to an increase in repeatedly reactive samples, resulting in a higher rate of look-back units and plasma waste.
Background and Objectives
In addition to supplying safe and sufficient blood and blood components, Iranian Blood Transfusion Organization (IBTO) has supplied surplus plasma for plasma fractionation to produce plasma-derived medicine products (PDMPs) since 2005. The look-back process is a requirement for contract fractionation and aims to improve the safety of PDMPs and blood components. This study investigates the trend of look-back units due to repeatedly reactive screening test results during 2018-2021.
Materials and Methods
In this serial cross-sectional study, the data gathered from the look-back form, including the number of lookback cases, lookback due to repeatedly reactive samples, confirmatory test results, and changes in test kits. The data were entered into SPSS software, and statistical analysis were carried out using the chi-square test and incidence rate ratio in R software.
Results
In 2019, after changing the screening methods and kits, there was a significant increase in the look-back rate and the number of repeatedly reactive samples in screening tests. The prevalence of repeatedly reactive samples in the HBsAg screening test was lower than that of HIV and HCV. The confirmatory test showed negative results for HCV and HIV at rates of 85% and 90%, respectively.
Conclusions
The change in screening methods and kits can lead to an increase in repeatedly reactive samples, resulting in a higher rate of look-back units and plasma waste.
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