Volume 21, Issue 2 (Summer 2024)
Sci J Iran Blood Transfus Organ 2024, 21(2): 118-128 |
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Yari F, Zaman Vaziri M, Bagheri N, Teimourpour A, Sabaghi F, Mortezapour Barfi F. Investigating the distribution of HLA-DRB1 allelic groups in Iranian ethnic groups. Sci J Iran Blood Transfus Organ 2024; 21 (2) :118-128
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Investigating the distribution of HLA-DRB1 allelic
groups in Iranian ethnic groups
Yari F.1, Zaman Vaziri M.1, Bagheri N.1, Teimourpour A.1, , Sabbaghi F.1,
Mortezapour Barfi F.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Abstract
Background and Objectives
This study looked at the frequency of HLA alleles and their genetic diversity in specific Iranian ethnic groups. This is important for the successful transplantation of hematopoietic stem cells.
Materials and Methods
In this descriptive study, HLA-DRB1 alleles were determined in low resolution level for donors using the PCR-SSP method. By using the HLA lab data and the stem cell donors’ information in Iranian Blood Transfusion Organization, the ethnic and HLA information from the Gilak (n = 510, 24.70%), Lur (n = 465, 22.53%), Kurd (n = 719, 34.84%), and Arab (n = 370, 17.93%) ethnicities were collected and analyzed. The relationship between alleles and ethnicity was examined, and a statistically significant relationship (p < 0.05) between the frequency of alleles in the studied ethnic groups was evaluated using the chi-square test.
Results
The low frequency allelic groups related to HLA-DRB1 were HLA-DRB1*09 (0.6%), HLA-DRB1*12 (0.8%), and HLA-DRB1*08 (1.6%). Allelic groups with higher frequency included HLA-DRB1*11 (22.7%), HLA-DRB1*03 (11.8%), HLA-DRB1*15 (11.7%), and HLA-DRB1*04 (11.1%). Among the allelic groups of HLA-DRB1, the frequency of 9 HLA-DRB1 allelic groups showed significant differences in the studied populations.
Conclusions
The frequency of several allelic groups showed significant differences among Iranian ethnicities. Identifying similarities and differences in the frequency of HLA alleles among Iranian ethnicities can help not only expand the pool of donors in registries but also assist in planning for providing of hematopoietic stem cell donors for patients from different Iranian ethnic groups.
Key words: HLA-DRB1, Ethnicity, Iran
Received: 13 May 2024
Accepted:27 May 2024
Correspondence: Yari F., PhD of Immunology. Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 82052237; Fax: (+9821) 88601555
E-mail: f.yari@ibto.ir
- Eisenbrey AB, Kopko PM. The HLA System. In: Technical Manual. 20th ed. USA: AABB; 2020. p. 479-99.
- HLA Alleles Numbers; March 2024. Available from: https://hla.alleles.org/nomenclature/stats.html.
- Shaiegan M, Zolfaghari Anaraki S. Unrelated stem cell donor registries in the world and Iran. Sci J Iran Blood Transfus Organ 2014, 11(2): 164-76. [Article in Farsi]
- Farjadian S, Naruse T, Kawata K, Ghaderi A, Bahram S, Inoko H. Molecular analysis of HLA allele frequencies and haplotypes in Baloch of Iran compared with related populations of Pakistan. Tissue Antigens 2004; 64(5): 581-7.
- Shaiegan M, Yari F, Abolghasemi H, Bagheri N, Paridar M, Heidari A, et al . Allele Frequencies of HLA-A, B and DRB1 among People of Fars Ethnicity Living in Tehran. IJBC 2011; 4: 55-9.
- Arab M, Pourpak Z, Mohammadian S, Zare A, Shakiba Y, Shokouhi Shoormasti R, et al. The Frequency of Human Leukocyte Antigen Class I and II Alleles and the Relationship Between Haplotypes in Gilaks Population of Iran. Immunoregulation 2019; 2: 57-66.
- Ghafouri-Fard S, Mahmud Hussen B, Pashmforoush S , Taghi Akbari M , Arsang-Jang S, Nazer N, et al. HLA alleles and haplotype frequencies in Iranian population. Hum Antibodies 2022; 30(2): 79-96.
- Farjadian S, Moqadam FA, Ghaderi A. HLA class II gene polymorphism in Parsees and Zoroastrians of Iran. Int J Immunogenet 2006; 33(3): 185-91.
- Farjadian S, Ota M, Inoko H, Ghaderi A. The genetic relationship among Iranian ethnic groups: an anthropological view based on HLA class II gene polymorphism. Mol Biol Rep 2009; 36(7): 1943-950.
- Yari F, Bagheri B, Teimurpour A, Zaman-Vaziri M, Sabaghi F, Mortezapour Barfi F. Frequency of rare HLA-A allelic groups in Gilak, Lur, Kurdish and Arab ethnic groups of Iran. Sci J Iran Blood Transfus Organ 2022; 19 (3): 191-9. [Article in Farsi]
- Yari F, Sobhani M, Sabaghi F, Zaman - Vaziri M, Bagheri N, Talebian A. Frequencies of HLA-DRB1 in Iranian normal population and in patients with Acute Lymphoblastic Leukemia. Arch Med Res 2008; 39(2): 205-8.
- Abedini F, Rahmanian N , Heidari Z, Feizi A, Sherkat R , Rezaei M. Diversity of HLA class I and class II alleles in Iran populations: Systematic review and Meta-Analaysis. Transpl Immunol 2021; 69: 101472.
- Khazaei HA, Rezaei N, Aghamohammadi A, Amirzargar AA. Human Leukocyte Antigen Profile of Two Ethnic Groups in Southeast of Iran. Iran J Allergy Asthma Immunol 2007; 6(4): 223-46.
- Nikbin B, Nicknam MH, Hadinedoushan H, Ansaripour B, Moradi B, Yekaninejad M, et al. Human Leukocyte Antigen (HLA) Class I and II
Polymorphism in Iranian Healthy Population from Yazd Province. Iran J Allergy Asthma Immunol 2017; 16(1): 1-13. - Mashayekhi P, Omrani MD, Yassin Z, Dehghanifard A, Ashouri L, Aghabozorg Afjeh SS, Shabanzadeh Z. Influence of HLA-A, -B, -DR Polymorphisms on the Severity of COVID-19: A Case-Control Study in the Iranian Population. Arch Iran Med 2023; 26(5): 261-6.
- Eimanzadeh M, Mohebali M, Zarrabi M, Rahimi Foroushani A, Kazemi M, Hajjaran H et al. The Association of Human Leucocyte Antigen (HLA) Class I and II Genes with Cutaneous and Visceral Leishmaniasis in Iranian Patients: A Preliminary Case-Control Study. Iran J Parasitol 2023; 18: 155-64.
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Sci J Iran Blood Transfus Organ 2024; 21 (2): 118-128 |
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Original Article
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groups in Iranian ethnic groups
Yari F.1, Zaman Vaziri M.1, Bagheri N.1, Teimourpour A.1, , Sabbaghi F.1,
Mortezapour Barfi F.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Abstract
Background and Objectives
This study looked at the frequency of HLA alleles and their genetic diversity in specific Iranian ethnic groups. This is important for the successful transplantation of hematopoietic stem cells.
Materials and Methods
In this descriptive study, HLA-DRB1 alleles were determined in low resolution level for donors using the PCR-SSP method. By using the HLA lab data and the stem cell donors’ information in Iranian Blood Transfusion Organization, the ethnic and HLA information from the Gilak (n = 510, 24.70%), Lur (n = 465, 22.53%), Kurd (n = 719, 34.84%), and Arab (n = 370, 17.93%) ethnicities were collected and analyzed. The relationship between alleles and ethnicity was examined, and a statistically significant relationship (p < 0.05) between the frequency of alleles in the studied ethnic groups was evaluated using the chi-square test.
Results
The low frequency allelic groups related to HLA-DRB1 were HLA-DRB1*09 (0.6%), HLA-DRB1*12 (0.8%), and HLA-DRB1*08 (1.6%). Allelic groups with higher frequency included HLA-DRB1*11 (22.7%), HLA-DRB1*03 (11.8%), HLA-DRB1*15 (11.7%), and HLA-DRB1*04 (11.1%). Among the allelic groups of HLA-DRB1, the frequency of 9 HLA-DRB1 allelic groups showed significant differences in the studied populations.
Conclusions
The frequency of several allelic groups showed significant differences among Iranian ethnicities. Identifying similarities and differences in the frequency of HLA alleles among Iranian ethnicities can help not only expand the pool of donors in registries but also assist in planning for providing of hematopoietic stem cell donors for patients from different Iranian ethnic groups.
Key words: HLA-DRB1, Ethnicity, Iran
Received: 13 May 2024
Accepted:27 May 2024
Correspondence: Yari F., PhD of Immunology. Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 82052237; Fax: (+9821) 88601555
E-mail: f.yari@ibto.ir
Send email to the article author
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