Volume 21, Issue 3 (Autumn 2024)                   Sci J Iran Blood Transfus Organ 2024, 21(3): 245-253 | Back to browse issues page

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Mohammadali F, Pezeshki S, Hosseini E. Factors involved in the formation of platelet aggregates. Sci J Iran Blood Transfus Organ 2024; 21 (3) :245-253
URL: http://bloodjournal.ir/article-1-1532-en.html
Factors involved in the formation of platelet aggregates
F. Mohammadali , S.M.S. Pezeshki , E. Hosseini *
Keywords: Key words: Blood platelets, Blood Buffy Coat, Platelet-Rich plasma, Platelet Aggregation
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Sci J Iran Blood Transfus Organ 2024; 21 (3): 245-253
Review Article
 

 Factors involved in the formation of  platelet aggregates

Mohammadali F.1, Pezeshki S.M.S.1, Hosseini E.1



1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran


Abstract
Background and Objectives
The collection and storage of platelets is associated with several challenges, to prevent the activation of platelets on the one hand and maintain their functional capacity during blood transfusion on the other hand. Today, one of the problems of platelet concentrate is the existence of platelet aggregations. The suspended particles in the platelet concentrate are believed to contain platelets that accumulate during the preparation and separation. The purpose of this study was to review important variables in the formation of platelet aggregations.

Materials and Methods
In this review article, 47 articles about aggregates in platelet products were studied from the PubMed database with platelet concentrate and platelet aggregate keywords.

Results
In the reviewed studies, the accumulation of platelets in the platelet concentrates prepared by the Platelet-rich plasma (PRP) method was higher than in the buffy coat and apheresis methods. Various factors such as storage temperature, time and temperature of platelet rest, pH, induced physical stimulation, type of platelet bag, presence of bacteria, and variables related to the donor were considered as factors involved in the formation of platelet aggregation.

Conclusions 
It is necessary to know the important variables in the formation of platelet aggregations to improve the platelet product's quality and increase the platelet transfusion's effectiveness. Using the Buffy coat method, standardizing time and temperature, preventing bacterial contamination, and considering the variables related to the donor are some of the proposed solutions to reduce the possibility of platelet aggregation.

Key words: Blood platelets, Blood Buffy Coat, Platelet-Rich plasma, Platelet Aggregation






Received:    1 Jun 2024
Accepted: 23 Jul  2024



Correspondence: Hosseini E., PhD in Hematology. Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88699531; Fax: (+9821) 88699531
E-mail: 
1- Acridine Orange
1- Biological safety cabinet
1- Platelet Concentrate
2- Food and Drug Administration
3- Normal Skin Flora
4- Platelet Rich Plasma-Platelet Concentrate
5- Eosin-Methylene blue
6- Thioglycolate
1- Acridine Orange
1- Biological safety cabinet
1- Platelet Concentrate
2- Food and Drug Administration
3- Normal Skin Flora
4- Platelet Rich Plasma-Platelet Concentrate
5- Eosin-Methylene blue
6- Thioglycolate
e.hosseini10@yahoo.com.au





 
Type of Study: Review Article | Subject: Blood Transfusion
Published: 2024/10/1
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