Volume 20, Issue 3 (َAutumn 2023)
Sci J Iran Blood Transfus Organ 2023, 20(3): 255-265 |
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Pourmokhtar M. The role of platelet products in the treatment of microbial infections. Sci J Iran Blood Transfus Organ 2023; 20 (3) :255-265
URL: http://bloodjournal.ir/article-1-1485-en.html
URL: http://bloodjournal.ir/article-1-1485-en.html
Abstract: (785 Views)
Abstract
Background and Objectives
Today, the issue of microbial resistance is considered as one of the most important challenges in the field of public health and the use of new biocompatible, safe and effective antimicrobial compounds is very important to solve this problem. Therefore, according to the antimicrobial properties of platelets, treatments based on platelet products can be used as complementary approaches along with antibiotics to treat microbial infections. In this review article, the properties and mechanism of the antimicrobial effect of platelets and platelet products along with some of the available evidence in this field have been briefly described.
Materials and Methods
The search process was done in Google scholar and PubMed databases using keywords “Platelets”, “Platelet-rich plasma” and “Anti-Infective Agents” without time restrictions. 107 relevant articles were selected and their findings regarding the properties and mechanism of the antimicrobial effect of platelets and platelet products were used.
Results
Antimicrobial activities of platelet products are due to the presence of a large number of platelets and various types of bioactive molecules, high amounts of platelet microbicidal proteins, and using multiple mechanisms. On the other hand, biocompatibility, safety, high clinical efficacy and limited side effects are some of the advantages of using platelet products. However, standardization and optimization of their preparation protocols are also important challenges.
Conclusions
The use of platelet products together with antibiotics is a suitable option to treat various microbial infections.
Background and Objectives
Today, the issue of microbial resistance is considered as one of the most important challenges in the field of public health and the use of new biocompatible, safe and effective antimicrobial compounds is very important to solve this problem. Therefore, according to the antimicrobial properties of platelets, treatments based on platelet products can be used as complementary approaches along with antibiotics to treat microbial infections. In this review article, the properties and mechanism of the antimicrobial effect of platelets and platelet products along with some of the available evidence in this field have been briefly described.
Materials and Methods
The search process was done in Google scholar and PubMed databases using keywords “Platelets”, “Platelet-rich plasma” and “Anti-Infective Agents” without time restrictions. 107 relevant articles were selected and their findings regarding the properties and mechanism of the antimicrobial effect of platelets and platelet products were used.
Results
Antimicrobial activities of platelet products are due to the presence of a large number of platelets and various types of bioactive molecules, high amounts of platelet microbicidal proteins, and using multiple mechanisms. On the other hand, biocompatibility, safety, high clinical efficacy and limited side effects are some of the advantages of using platelet products. However, standardization and optimization of their preparation protocols are also important challenges.
Conclusions
The use of platelet products together with antibiotics is a suitable option to treat various microbial infections.
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