Volume 20, Issue 2 (Summer 2023)                   Sci J Iran Blood Transfus Organ 2023, 20(2): 134-142 | Back to browse issues page

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Mokariani Z, Mokariani M, Amiri F. Evaluation of the effect of IL-6, LDH, CRP levels on the disease severity in patients with coronavirus in Sina Hospital in 2020. Sci J Iran Blood Transfus Organ 2023; 20 (2) :134-142
URL: http://bloodjournal.ir/article-1-1484-en.html
Evaluation of the effect of IL-6, LDH, CRP levels on the disease severity in patients with coronavirus in Sina Hospital in 2020
Z. Mokariani , M. Mokariani , F. Amiri *
Keywords: Key words: Virus, IL-6, Disease Severity
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Sci J Iran Blood Transfus Organ 2023;20 (2): 134-142
Orginal Article
 

Evaluation of the effect of IL-6, LDH, CRP levels on
the disease severity in patients with coronavirus
in Sina Hospital in 2020

Mokariani Z.1, Mokariani M.1, Amiri F.2


1Student Research Committee, Hamadan University of Medical Science, Hamadan, Iran
2Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran


Abstract
Background and Objectives
Corona is caused by a viral infection called acute respiratory syndrome corona virus 2 which spreads rapidly, causing irreparable damage and death. In order to predict and develop treatment algorithms, the study of biomarkers is important in determining the severity of the disease. Therefore, we investigated the correlation of Interleukin 6 IL-6, Lactate dehydrogenase LDH, C reactive protein CRP and disease severity in COVID-19 patients.

Materials and Methods
In this descriptive and analytical cross-sectional study, the information of 365 coronavirus hospitalized patients randomly selected in Sina Hamadan hospital during 2019 was entered into SPSS 26. The severity of the disease was also measured according to the defined reference and clinical symptoms and classified into two levels. The data were analyzed with  gamma correlation instability test, Somers' D at significance level of p value <0.05.

Results
It was found that IL-6 with a correlation coefficient of 0.506, LDH with a correlation coefficient of 0.291 and CRP with a correlation coefficient of 0.23, all at the level of 0.01 (p value = 0.01), have a positive effect on the severity of Corona disease and the amount of this positive effect is based on Somers' effect coefficient d 0.839, 0.458 and 0.358, respectively.

Conclusions 
Patients with severe COVID-19 have significantly higher serum levels of CRP, LDH and IL-6. Baseline levels of IL-6, CRP, and LDH were closely related to the severity of COVID-19 disease. These laboratory markers can be used as clinical indicators of disease exacerbation and prognosis of COVID-19.

Key words: Virus, IL-6, Disease Severity





Received:  16  Jan 2023
Accepted:   1 Mar 2023



Correspondence: Amiri F., PhD of Hematology & Blood Banking. Assistant Professor in Department of Medical Laboratory Sciences, School of Para Medicine, Hamadan University of Medical Sciences.
Postal Code: 6517838741, Hamadan, Iran. Tel: (+9881) 38380109; Fax: (+9881) 38381017
E-mail: f.amiri@umsha.ac.ir
 
Type of Study: Research | Subject: Imunology
Published: 2023/07/1
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