Volume 20, Issue 1 (Spring 2023)                   bloodj 2023, 20(1): 53-65 | Back to browse issues page

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Kiani nodeh F, Ghasemzadeh M, Hosseini E. Storage-dependent oxidative damage in gamma irradiated platelet products. bloodj 2023; 20 (1) :53-65
URL: http://bloodjournal.ir/article-1-1474-en.html
Storage-dependent oxidative damage in gamma irradiated platelet products
F. Kiani nodeh , M. Ghasemzadeh , E. Hosseini *
Keywords: Blood Transfusion, Platelet-Rich Plasma, Gamma Rays
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References:
  1. Schubert P, Devine DV. Towards targeting platelet storage lesion-related signaling pathways. Blood Transfus 2010; 8(Suppl 3): s69.
  2. Smethurst PA. Aging of platelets stored for transfusion. Platelets 2016; 27(6): 526-34.
  3. Albanyan AM, Harrison P, Murphy MF. Markers of platelet activation and apoptosis during storage of apheresis-and buffy coat–derived platelet concentrates for 7 days. Transfusion 2009; 49(1): 108-17.
  4. McCullough J. Overview of platelet transfusion. Semin Hematol 2010; 47(3): 235-42.
  5. Garraud O, Cognasse F, Tissot JD, Chavarin P, Laperche S, Morel P, et al. Improving platelet transfusion safety: biomedical and technical considerations. Blood Transfus 2016; 14(2): 109-22.
  6. Hosseini E, Mohtashami M, Ghasemzadeh M. Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets. Thromb J 2019; 17(1): 1-11.
  7. Hosseini E, Ghasemzadeh M, Atashibarg M, Haghshenas M. ROS scavenger, N-acetyl-l-cysteine and NOX specific inhibitor, VAS2870 reduce platelets apoptosis while enhancing their viability during storage. Transfusion 2019; 59(4): 1333-43.
  8. Mehrpoori M, Hosseini E, Amini Kafi-Abad S, Ghasemzadeh M. The effect of pre-storage leukoreduction on the levels of expression and shedding of the pro-inflammatory molecule P-Sel in random  PRP  platelets.  Sci  J    Iran Blood Transfus Organ 2015; 12(2): 153-62. [Article in Farsi]
  9. Shrivastava M. The platelet storage lesion. Transfus Apher Sci 2009; 41(2): 105-13.
  10. Ghasemzadeh M, Hosseini E. Platelet granule release is associated with reactive oxygen species generation during platelet storage: a direct link between platelet pro-inflammatory and oxidation states. Thromb Res 2017; 156: 101-4.
  11. Ghasemzadeh M, Hosseini E, Roudsari ZO, Zadkhak P. Intraplatelet reactive oxygen species (ROS) correlate with the shedding of adhesive receptors, microvesiculation and platelet adhesion to collagen during storage: does endogenous ROS generation downregulate platelet adhesive function? Thromb Res 2018; 163: 153-61.
  12. Agarwal P, Ray V, Choudhury N, Chaudhary R. Effect of pre-storage gamma irradiation on red blood cells. Indian J Med Res 2005; 122(5): 385-7. 
  13. Anderson KC, Goodnough LT, Sayers M, Pisciotto PT, Kurtz SR, Lane TA, et al. Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease. Blood 1991; 77(10): 2096-102.
  14. Moroff G, Luban N. The irradiation of blood and blood components to prevent graft-versus-host disease: technical issues and guidelines. Transfus Med Rev 1997; 11(1): 15-26.
  15. Marrocco C, D'alessandro A, Girelli G, Zolla L. Proteomic analysis of platelets treated with gamma irradiation versus a commercial photochemical pathogen reduction technology. Transfusion 2013; 53(8): 1808-20.
  16. Nodeh FK, Hosseini E, Ghasemzadeh M. The effect of gamma irradiation on platelet redox state during storage. Transfusion 2021; 61(2): 579-93. 
  17. Bashir S, Naik F, Cardigan R, Thomas S. Effect of X-irradiation on the quality of red cell concentrates. Vox Sang 2011; 101(3): 200-7.
  18. Przepiorka D, Leparc GF, Stovall MA, Werch J, Lichtiger B. Use of irradiated blood components: practice parameter. Am J Clin Pathol 1996; 106(1): 6-11.
  19. Saenko Y, Cieslar-Pobuda A, Skonieczna M, Rzeszowska-Wolny J. Changes of reactive oxygen and nitrogen species and mitochondrial functioning in human K562 and HL60 cells exposed to ionizing radiation. Radiat Res 2013; 180(4): 360-6.
  20. Yoshida T, Goto S, Kawakatsu M, Urata Y, Li TS. Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation. Free Radic Res 2012; 46(2): 147-53. 
  21. Williamson L. UK guidelines for the irradiation of blood components. Transfus Sci 1995; 16(2): 135-7.
  22. Saglam S. Blood Irradiation. Modern Approaches To Quality Control [Internet]. 2011 Nov 9; Available from: http://dx.doi.org/10.5772/20578.
  23. Mallhi R, Biswas A, Philip J, Chatterjee T. To study the effects of gamma irradiation on single donor apheresis platelet units by measurement of cellular counts, functional indicators and a panel of biochemical parameters, in order to assess pre-transfusion platelet quantity  and quality during the shelf life of the product. Med J Armed Forces India2016; 72(1): 19-26.
  24. Clarke G, Chargé S. Clinical Guide to Transfusion. Chapter; 2013. Available from: https://professionaleducation. blood. ca/ en/ transfusion/ clinical-guide-transfusion.
  25. Jacobs GP. A review on the effects of ionizing radiation on blood and blood components. Radiation Physics and Chemistry 1998; 53(5): 511-23.
  26. Violi F, Pignatelli P. Platelet NOX, a novel target for anti-thrombotic treatment. Thromb Haemost 2014; 112(05): 817-23.
  27. Begonja AJ, Gambaryan S, Geiger Jr, Aktas B, Pozgajova M, Nieswandt B, et al. Platelet NAD (P) H-oxidase–generated ROS production regulates αIIbβ3-integrin activation independent of the NO/cGMP pathway. Blood 2005; 106(8): 2757-60.
  28. Augsburger F, Filippova A, Rasti D, Seredenina T, Lam M, Maghzal G, et al. Pharmacological characterization of the seven human NOX isoforms and their inhibitors. Redox Biol 2019; 26: 101272.
  29. Vlădăreanu A, Popov V, Radeşi S, Onisâi M, Bumbea H. Role of reactive oxygen species in platelet function in normal states and chronic myeloproliferative disorders. Rom J Bioch 2008; 45: 221-32.
  30. Sonego G, Abonnenc M, Tissot JD, Prudent M, Lion N. Redox Proteomics and Platelet Activation: Understanding the Redox Proteome to Improve Platelet Quality for Transfusion. Int J Mol Sci 2017; 18(2): 387.
  31. Husain N, Kumar A, RADICALS F. Reactive oxygen species and natural antioxidants: a review. Advances in Bioresearch 2012; 3(4): 164-75.
  32. Abonnenc M, Sonego G, Crettaz D, Aliotta A, Prudent M, Tissot JD, et al. In vitro study of platelet function confirms the contribution of the ultraviolet B (UVB) radiation in the lesions observed in riboflavin/UVB-treated platelet concentrates. Transfusion 2015; 55(9): 2219-30.
  33. Violi F, Pignatelli P. Platelet oxidative stress and thrombosis. Thromb Res 2012; 129(3): 378-81.
  34. Qiao J, Arthur JF, Gardiner EE, Andrews RK, Zeng L, Xu K. Regulation of platelet activation and thrombus formation by reactive oxygen species. Redox Biol 2018; 14: 126-30.
  35. Zharikov S, Shiva S. Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease. Biochem Soc Trans 2013; 41(1): 118-23.
  36. Villarroel JPP, Figueredo R, Guan Y, Tomaiuolo M, Karamercan MA, Welsh J, et al. Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function. J Surg Res 2013; 184(1): 422-9.
  37. Masselli E, Pozzi G, Vaccarezza M, Mirandola P, Galli D, Vitale M, et al. ROS in platelet biology: functional aspects and methodological insights. Int J Mol Sci 2020; 21(14): 4866.
  38. Ehteramolsadat H, Amin S, Oushyani RZ, Faranak K, Mehran G. Reducing state attenuates ectodomain shedding of GPVI while restoring adhesion capacities of stored platelets: Evidence addressing the controversy around the effects of redox condition on thrombosis.  J  Thromb  Thrombolysis  2020; 50(1): 123-34.
  39. Vianello A, Casolo V, Petrussa E, Peresson C, Patui S, Bertolini A, et al. The mitochondrial permeability transition pore (PTP)--an example of multiple molecular exaptation? Biochim Biophys Acta 2012; 1817(11): 2072-86.
  40. Jackson SP, Schoenwaelder SM. Procoagulant platelets: are they necrotic? Blood 2010; 116 (12): 2011-8. 
  41. Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 2016; 1863(12): 2977-92.
  42. Gyulkhandanyan AV, Mutlu A, Freedman J, Leytin V. Markers of platelet apoptosis: methodology and applications. J Thromb Thrombolysis 2012; 33(4): 397-411.
  43. Sivandzade F, Bhalerao A, Cucullo L. Analysis of the mitochondrial membrane potential using the cationic JC-1 dye as a sensitive fluorescent probe. Bio Protoc 2019; 9(1): e3128-e.
  44. Elefantova K, Lakatos B, Kubickova J, Sulova Z, Breier AJIjoms. Detection of the mitochondrial membrane potential by the cationic dye JC-1 in L1210 cells with massive overexpression of the plasma membrane ABCB1 drug transporter. Int J Mol Sci 2018; 19(7): 1985.
  45. Picker SM, Steisel A, Gathof BSJT. Effects of Mirasol PRT treatment on storage lesion development in plasma-stored apheresis-derived platelets compared to untreated and irradiated units. Transfusion 2008; 48(8): 1685-92.
  46. Kawamura K, Qi F, Kobayashi J. Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production. J Radiat Res 2018; 59(suppl_2): ii91-ii7.
  47. Collins-Underwood JR, Zhao W, Sharpe JG, Robbins ME. NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Free Radic Biol Med 2008; 45(6): 929-38.
  48. Steinauer KK, Gibbs I, Ning S, French JN, Armstrong J, Knox SJ. Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells. Int J Radiat Oncol Biol Phys 2000; 48(2): 325-8.
  49. Barrera G. Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncol 2012; 2012: 137289.
  50. Kim E, Kim W, Lee S, Chun J, Kang J, Park G, et al. TRAF4 promotes lung cancer aggressiveness by modulating tumor microenvironment in normal fibroblasts. Sci Rep 2017; 7(1): 1-14.
  51. Skripchenko A, Myrup A, Thompson-Montgomery D, Awatefe H, Wagner SJ. Mitochondrial dysfunction of platelets stored in first-and second-generation containers is, in part, associated with elevated carbon dioxide levels. Transfusion 2011; 51(2): 371-9.
  52. Manasa K, Vani R. Influence of oxidative stress on stored platelets. Adv Hematol 2016; 2016: 4091461.
  53. Burch P, Burch JW. Alterations in glutathione during 
  54. storage of human platelet concentrates. Transfusion 1987; 27(4): 342-6.
  55. Hervig T, Mansoor M, Farstad M. Endogenous glutathione and platelet function in platelet concentrates stored in plasma or platelet additive solution. Transfus Med 2001; 11(2): 97-104.
  56. Burch P, Aman M, Burch J. Modification of glutathione content in platelet concentrates by the use of acivicin. Transfusion 1994; 34(5): 421-6.
  57. Göker B, Özsavcı D, Şener A, Aksoy H, Bağışgil V, Demirel GY, et al. Oxidative alterations during human platelet storage. Marmara Pharmaceutical J 2011; 15(1): 38-42.
  58. Abonnenc M, Crettaz D, Marvin L, Grund B, Sonego G, Bardyn M, et al. Metabolomic profiling highlights oxidative damages in platelet concentrates treated for pathogen inactivation and shows protective role of urate. Metabolomics 2016; 12(12): 188.
  59. Nodeh FK, Hosseini E, Ghasemzadeh M. The effect of gamma irradiation on platelet redox state during storage. Transfusion 2021; 61(2): 579-93. 
  60. Ghasemzadeh M, Hosseini E. Platelet granule release is associated with reactive oxygen species generation during platelet storage: A direct link between platelet pro-inflammatory and oxidation states. Thromb Res 2017; 156: 101-4.
  61. Zimmermann R, Schmidt S, Zingsem J, Glaser A, Weisbach V, Ruf A, et al. Effect of gamma radiation on the in vitro aggregability of WBC-reduced apheresis platelets. Transfusion 2001; 41(2): 236-42.
  62. Tynngård N, Studer M, Lindahl TL, Trinks M, Berlin GJT. The effect of gamma irradiation on the quality of apheresis platelets during storage for 7 days. Transfusion 2008; 48(8): 1669-75.
  63. Van Aelst B, Devloo R, Vandekerckhove P, Compernolle V, Feys HBJT. Ultraviolet C light pathogen inactivation treatment of platelet concentrates preserves integrin activation but affects thrombus formation kinetics on collagen in vitro. Transfusion 2015; 55(10): 2404-14.
  64. Read E, Kodis C, Carter C, Leitman SJT. Viability of platelets following storage in the irradiated state. A pair-controlled study. Transfusion 1988; 28(5): 446-50.
  65. Sigle JP, Infanti L, Studt JD, Martinez M, Stern M, Gratwohl A, et al. Comparison of transfusion efficacy of amotosalen-based pathogen-reduced platelet components and gamma-irradiated platelet components. Transfusion 2013; 53(8): 1788-97.
  66. Infanti L, Stebler C, Job S, Ruesch M, Gratwohl A, Irsch J, et al. Pathogen-inactivation of platelet components with the INTERCEPT Blood System™: a cohort study. Transfusion 2011; 45(2): 175-81.
  67. Julmy F, Ammann RA, Fontana S, Taleghani BM, Hirt A, Leibundgut K. Transfusion efficacy of apheresis platelet concentrates irradiated at the day of transfusion is significantly superior compared to platelets irradiated in advance. Transfus Med Hemother 2014; 41(3): 176-81.






Sci J Iran Blood Transfus Organ 2023;20(1): 53-65
 
Review Article
 
 



Storage-dependent oxidative damage in gamma irradiated platelet products

Kiani Nodeh F.1, Ghasemzadeh M.1, Hosseini E. 1


1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran



Abstract
Background and Objectives
Gamma irradiation (GI) to platelet products is a usual therapeutic procedure for preventing the transfusion associated graft versus host disease (TA-GVHD) in susceptible recipients. Nevertheless, some studies indicate a decrease in platelet recovery after transfusion, associated with higher levels of platelet storage lesion (PSL) in gamma irradiated platelets. In addition, the induction of oxidant stress, especially the increase in the production of reactive oxygen species (ROS) following the treatment of platelet products with gamma rays, has been reported in some studies. Therefore, given the known effects of ROS on PSL induction, the review presented here, while introducing different sources of ROS production during storage, also discusses the importance of storage-dependent oxidative stress in platelet products exposed to gamma radiation. For this purpose, studies published in MEDLINE, PubMed and Google scholar were searched for relevant keywords, among which 66 studies were cited in this review.

Key words: Blood Transfusion, Platelet-Rich Plasma, Gamma Rays



















Received: 13 Nov 2022
Accepted:  8 Feb  2023



Correspondence: Hosseini E., PhD in Hematology. Associate Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88699531; Fax: (+9821) 88699531
E-mail:
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Type of Study: Review Article | Subject: Blood Transfusion
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