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:: Volume 20, Issue 1 (Spring 2023) ::
Sci J Iran Blood Transfus Organ 2023, 20(1): 53-65 Back to browse issues page
Storage-dependent oxidative damage in gamma irradiated platelet products
F. Kiani nodeh , M. Ghasemzadeh , E. Hosseini *
Keywords: Blood Transfusion, Platelet-Rich Plasma, Gamma Rays
Full-Text [PDF 628 kb]   (605 Downloads)     |   Abstract (HTML)  (825 Views)
Type of Study: Review Article | Subject: Blood Transfusion
Published: 2023/04/4
Full-Text:   (766 Views)
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Sci J Iran Blood Transfus Organ 2023;20(1): 53-65
 
Review Article
 
 



Storage-dependent oxidative damage in gamma irradiated platelet products

Kiani Nodeh F.1, Ghasemzadeh M.1, Hosseini E. 1


1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran



Abstract
Background and Objectives
Gamma irradiation (GI) to platelet products is a usual therapeutic procedure for preventing the transfusion associated graft versus host disease (TA-GVHD) in susceptible recipients. Nevertheless, some studies indicate a decrease in platelet recovery after transfusion, associated with higher levels of platelet storage lesion (PSL) in gamma irradiated platelets. In addition, the induction of oxidant stress, especially the increase in the production of reactive oxygen species (ROS) following the treatment of platelet products with gamma rays, has been reported in some studies. Therefore, given the known effects of ROS on PSL induction, the review presented here, while introducing different sources of ROS production during storage, also discusses the importance of storage-dependent oxidative stress in platelet products exposed to gamma radiation. For this purpose, studies published in MEDLINE, PubMed and Google scholar were searched for relevant keywords, among which 66 studies were cited in this review.

Key words: Blood Transfusion, Platelet-Rich Plasma, Gamma Rays



















Received: 13 Nov 2022
Accepted:  8 Feb  2023



Correspondence: Hosseini E., PhD in Hematology. Associate Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88699531; Fax: (+9821) 88699531
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Kiani nodeh F, Ghasemzadeh M, Hosseini E. Storage-dependent oxidative damage in gamma irradiated platelet products. Sci J Iran Blood Transfus Organ 2023; 20 (1) :53-65
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فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
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