Volume 19, Issue 4 (winter 2022)                   Sci J Iran Blood Transfus Organ 2022, 19(4): 329-344 | Back to browse issues page

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Shirdare M, Khansari S, Amiri F, Rekabi zadeh P. The angiogenic role of platelets in the physiologic, pathologic, and tumorigenic conditions. Sci J Iran Blood Transfus Organ 2022; 19 (4) :329-344
URL: http://bloodjournal.ir/article-1-1472-en.html
The angiogenic role of platelets in the physiologic, pathologic, and tumorigenic conditions
M. Shirdare , S.M.P Khansari , F. Amiri * , P. Rekabi zadeh
Keywords: Key words: Platelets, Tumorigenesis, Physiologic Angiogenesis, Glycoprotein
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Sci J Iran Blood Transfus Organ 2022;19 (4): 329-344
Review Article
 


The angiogenic role of platelets in the physiologic,
 pathologic, and tumorigenic conditions

Shirdare M.1, Khansari S.M.P2, Amiri F.3, Rekabizadeh P.4


1Vice Chancellor for Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
2Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
3School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
4Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract
Background and Objectives
Platelets are known as the smallest cells in the blood cells with a key role in homeostasis and blood coagulation. Today, by increasing the clinical studies, the role of platelets in angiogenesis and pathological conditions such as tumorigenesis has been considered.

Materials and Methods
In this narrative review article, different articles were searched in the PubMed and Google scholar databases and Google search engine using proper key words. By reviewing 121 articles related to platelets, angiogenesis, and tumorgenesis in recent years, the role of platelets in angiogenesis and tumorigenesis was evaluated.

Results
Platelets are the source of vesicles, granules and growth factors, adhesion molecules and receptors, MicroRNA that are released after platelet activation. Platelets have both types of angiogenesis and anti-angiogenesis factors that act depending on the type of stimuli. On the other hand, these factors can be modified under stressful environmental conditions such as tumor formation and can increase the tumor growth and metastasis.

Conclusions 
Considering the function of platelets in homeostasis, coagulation, inflammation, repair, angiogenesis, and tumorigenesis and by understanding their regulation mechanisms in the formation of vessels and development of tumors, they can be used in the development and improvement of  the therapeutic methods related to angiogenesis diseases.

Key words: Platelets, Tumorigenesis, Physiologic Angiogenesis, Glycoprotein







Received:  30 Oct 2022
Accepted: 30 Nov 2022



Correspondence: Amiri F., PhD of Hematology & Blood Banking. Assistant Professor in Department of Medical Laboratory Sciences, School of Para Medicine, Hamadan University of Medical Sciences.
Postal Code: 6517838741, Hamadan, Iran. Tel: (+9881) 38380109; Fax: (+9881) 38381017
E-mail: f.amiri@umsha.ac.ir

 
Type of Study: Review Article | Subject: Hematology
Published: 2022/12/31
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